Title:Unraveling the Anti-Obesity Potential of Luteolin: Mechanistic Insights
Volume: 21
Issue: 3
Author(s): Akhil Sharma, Gagandeep Kaur, Amandeep Kaur and Sushma Devi*
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords:
Luteolin, antioxidant, anti-inflammatory, obesity, adipocytes, lipolysis.
Abstract: Luteolin, a flavonoid, has gained attention for its anti-obesity benefits. Luteolin has
been shown to regulate multiple aspects of adipose tissue biology, including adipocyte differentiation
and adipokine secretion. It prevents the formation of adipocytes by interfering with the expression
of important transcription factors, such as PPAR-γ and C/EBP-β. Furthermore, luteolin possesses
anti-inflammatory properties, inhibiting the production of pro-inflammatory adipokines,
such as TNF-α and IL-6. These actions help to reduce the persistent low-grade inflammation associated
with obesity, which eventually improves metabolic health. It increases the production of
adiponectin, an adipokine with anti-inflammatory and antioxidant properties. This change in the
adipokine level may result in metabolic benefits in obese persons. Additionally, the antioxidant activities
of luteolin shield adipocytes from oxidative stress, preserving their function and contributing
to overall metabolic equilibrium. This study provides scientific evidence supporting luteolin as
an anti-obesity agent in depth, focusing on its mechanisms of action, experimental studies, pharmaceutical
formulation studies, and other reported clinical evidence.
