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Current Nutrition & Food Science

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ISSN (Online): 2212-3881

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Review Article

Exploring the Therapeutic Potential of Chrysanthemum morifolium: An Ethnopharmacological Perspective

Author(s): Smriti Ojha, Pratik Kumar Vishwakarma, Shivendra Mani Tripathi and Sudhanshu Mishra*

Volume 20, Issue 5, 2024

Published on: 18 August, 2023

Page: [646 - 657] Pages: 12

DOI: 10.2174/1573401319666230803092050

Price: $65

Abstract

Aim: The current manuscript aims to discuss the ethnopharmacological relevance of the common plant Chrysanthemum morifolium, also known as pot mums and its potential therapeutic applications.

Methods: A bibliography survey was carried out using various electronic databases like google scholar, ScienceDirect, Springer, Scopus, PubMed, Wiley, etc. Other offline, as well as, online academic libraries were also used for the bibliography survey and compilation of data.

Result and Discussion: Traditional remedies have grown in both therapeutic and economic importance around the world and are used by various groups of people. While the use of these medications has grown, there are still concerns about their consistency, safety, and efficacy in many areas. Chrysanthemum is the peak three of the world’s mainly significant cut flowers with an important herb of traditional Chinese medicine (TCM). It contains abundant volatile oil and flavonoids. It has been used for a long time to treat allergies, cardiovascular disease, severe flu, hypertension, and sore throat. It also has characteristics such as anti-inflammatory, antibacterial, aromatic, demulcent, febrifuge, hepatic, hypotensive, refrigerant, etc.

Conclusion: It can be established from the complete study that various active constituents can be isolated from the plant which has potential therapeutic value and justifies its use on modern scientific parameters.

Keywords: Traditional chinese medicine, antioxidant, Chrysanthemum morifolium, flavonoids, allergies, cardiovascular disease.

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[1]
Lin LZ, Harnly JM. Identification of the phenolic components of chrysanthemum flower (Chrysanthemum morifolium Ramat). Food Chem 2010; 120(1): 319-26.
[http://dx.doi.org/10.1016/j.foodchem.2009.09.083]
[2]
Akihisa T, Yasukawa K, Oinuma H, et al. Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects. Phytochemistry 1996; 43(6): 1255-60.
[http://dx.doi.org/10.1016/S0031-9422(96)00343-3] [PMID: 8987908]
[3]
Youssef FS, Eid SY, Alshammari E, Ashour ML, Wink M, El-Readi MZ. Chrysanthemum indicum and chrysanthemum morifolium: Chemical composition of their essential oils and their potential use as natural preservatives with antimicrobial and antioxidant activities. Foods 2020; 9(10): 1460.
[http://dx.doi.org/10.3390/foods9101460] [PMID: 33066507]
[4]
Casida JE. Pyrethrum flowers and pyrethroid insecticides. Environ Health Perspect 1980; 34: 189-202.
[http://dx.doi.org/10.1289/ehp.8034189]
[5]
Mekapogu M, Kwon OK, Song HY, Jung JA. Towards the improvement of ornamental attributes in chrysanthemum: Recent progress in biotechnological advances. Int J Mol Sci 2022; 23(20): 12284.
[http://dx.doi.org/10.3390/ijms232012284] [PMID: 36293140]
[6]
Bradshaw M, Braun U, Götz M, Meeboon J, Takamatsu S. Powdery mildew of Chrysanthemum × morifolium: Phylogeny and taxonomy in the context of Golovinomyces species on Asteraceae hosts. Mycologia 2017; 109(3): 508-19.
[http://dx.doi.org/10.1080/00275514.2017.1358136] [PMID: 28854055]
[7]
Barnes J. Trease and Evans’ Pharmacognosy. Focus Altern Complement Ther 2010; 4(3): 151-2.
[8]
Hadizadeh H, Samiei L, Shakeri A. Chrysanthemum, an ornamental genus with considerable medicinal value: A comprehensive review. S Afr J Bot 2022; 144: 23-43.
[http://dx.doi.org/10.1016/j.sajb.2021.09.007]
[9]
Cojocariu A, Chelariu EL, Tănase C. Adventitious roots development and root system architecture of chrysanthemum cuttings. J Plant Dev 2018; 25: 91-8.
[http://dx.doi.org/10.33628/jpd.2018.25.1.91]
[10]
Kubitzki K. The families and genera of vascular plants. Springer Nature 2014; p. 76.
[11]
Lai JP, Lim YH, Su J, Shen HM, Ong CN. Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 848(2): 215-25.
[http://dx.doi.org/10.1016/j.jchromb.2006.10.028] [PMID: 17084113]
[12]
Sun S, Jiang P, Su W, et al. Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging. Cytotechnology 2016; 68(2): 229-40.
[http://dx.doi.org/10.1007/s10616-014-9773-5] [PMID: 25052044]
[13]
Deacon K, Mistry P, Chernoff J, Blank JL, Patel R. p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell 2003; 14(5): 2071-87.
[http://dx.doi.org/10.1091/mbc.e02-10-0653] [PMID: 12802076]
[14]
Ichihashi M, Ahmed NU, Budiyanto A, Wu A, Bito T, Ueda M, et al. Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J Dermatol Sci 2000; 23(S1): S45-50.
[15]
Hao DC, Song Y, Xiao P, Zhong Y, Wu P, Xu L. The genus Chrysanthemum: Phylogeny, biodiversity, phytometabolites, and chemodiversity. Front Plant Sci 2022; 13: 973197.
[http://dx.doi.org/10.3389/fpls.2022.973197]
[16]
Song C, Liu Y, Song A, et al. The chrysanthemum nankingense genome provides insights into the evolution and diversification of chrysanthemum flowers and medicinal traits. Mol Plant 2018; 11(12): 1482-91.
[http://dx.doi.org/10.1016/j.molp.2018.10.003] [PMID: 30342096]
[17]
Chen G, Kim HK, Klinkhamer PGL, Escobar-Bravo R. Site-dependent induction of jasmonic acid-associated chemical defenses against western flower thrips in Chrysanthemum. Planta 2020; 251(1): 8.
[http://dx.doi.org/10.1007/s00425-019-03292-2] [PMID: 31776674]
[18]
Jiang S, Wang M, Jiang Z, et al. Chemistry and pharmacological activity of sesquiterpenoids from the chrysanthemum genus. Molecules 2021; 26(10): 3038.
[http://dx.doi.org/10.3390/molecules26103038] [PMID: 34069700]
[19]
Xue LM, Qin XM, Guo JG. Comparative study on main components of chrysanthemum morifolium introduced in ruicheng in Shanxi province. Chin Tradit Herbal Drugs 2007; 38(5): 751-4.
[20]
Chang TL, Liou PS, Cheng PY, Chang HN, Tsai PJ. Borneol and luteolin from chrysanthemum morifolium regulate ubiquitin signal degradation. J Agric Food Chem 2018; 66(31): 8280-90.
[http://dx.doi.org/10.1021/acs.jafc.8b01972] [PMID: 29995407]
[21]
Shunying Z, Yang Y, Huaidong Y, Yue Y, Guolin Z. Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum. J Ethnopharmacol 2005; 96(1-2): 151-8.
[http://dx.doi.org/10.1016/j.jep.2004.08.031] [PMID: 15588664]
[22]
Guo Y, Zhang T, Zhong J, et al. Identification of the volatile compounds and observation of the glandular trichomes in opisthopappus taihangensis and four species of chrysanthemum. Plants 2020; 9(7): 855.
[http://dx.doi.org/10.3390/plants9070855] [PMID: 32640748]
[23]
Zheng SB, Tang J, Zhu JK, Li ZR, Wang JF. Simultaneous determination of total flavonoids and organic acids in chrysanthemum by UV-visible spectrophotometry. Asian J Chem 2014; 26(19): 6409-13.
[http://dx.doi.org/10.14233/ajchem.2014.16396]
[24]
Shahrajabian MH, Sun W, Zandi P, Cheng Q. A review of chrysanthemum, the eastern queen in traditional chinese medicine with healing power in modern pharmaceutical sciences. Appl Ecol Environ Res 2019; 17: 13355-69.
[25]
Clifford MN, Wu W, Kirkpatrick J, Kuhnert N. Profiling the chlorogenic acids and other caffeic acid derivatives of herbal chrysanthemum by LC-MSn. J Agric Food Chem 2007; 55(3): 929-36.
[http://dx.doi.org/10.1021/jf062314x] [PMID: 17263495]
[26]
Xie Y, Zhou C, Tu C, Zhang Z-L, Wang J-F. Quantitative determination of ferulic acid content in chrysanthemum morifolium cv. (chuju) continuous cropping soil using near infrared spectroscopy. Chin J Anal Chem 2017; 45(3): 363-8.
[http://dx.doi.org/10.1016/S1872-2040(17)61001-6]
[27]
Hou X, Huang X, Li J, et al. Extraction optimization and evaluation of the antioxidant and α-glucosidase inhibitory activity of polysaccharides from Chrysanthemum morifolium cv. Hangju. Antioxidants 2020; 9(1): 59.
[http://dx.doi.org/10.3390/antiox9010059] [PMID: 31936550]
[28]
Zheng Y, Wang XS, Fang J. Two acidic polysaccharides from the flowers of Chrysanthemum morifolium. J Asian Nat Prod Res 2006; 8(3): 217-22.
[http://dx.doi.org/10.1080/1028602042000324880] [PMID: 16864427]
[29]
Li Q, Wu Z, Wu H, Fang W, Chen F, Teng N. Transcriptome profiling unravels a vital role of pectin and pectinase in anther dehiscence in chrysanthemum. Int J Mol Sci 2019; 20(23): 5865.
[http://dx.doi.org/10.3390/ijms20235865] [PMID: 31766739]
[30]
Tao JH, Duan JA, Jiang S, Feng NN, Qiu WQ, Ling Y. Polysaccharides from Chrysanthemum morifolium Ramat ameliorate colitis rats by modulating the intestinal microbiota community. Oncotarget 2017; 8(46): 80790-803.
[http://dx.doi.org/10.18632/oncotarget.20477] [PMID: 29113344]
[31]
Hodaei M, Rahimmalek M, Behbahani M. Anticancer drug discovery from Iranian chrysanthemum cultivars through system pharmacology exploration and experimental validation. Sci Rep 2021; 11(1): 11767.
[http://dx.doi.org/10.1038/s41598-021-91010-y] [PMID: 34083561]
[32]
Guo N, Zou YP, Li HK, Kou P, Liu ZM, Fu YJ. Effective extraction and recovery of linarin from Chrysanthemum indicum L. flower using deep eutectic solvents. Microchem J 2020; 159: 105586.
[http://dx.doi.org/10.1016/j.microc.2020.105586]
[33]
Jang HY, Lee HS, Noh E, et al. Aqueous extract of Chrysanthemum morifolium Ramat. inhibits RANKL-induced osteoclast differentiation by suppressing the c-fos/NFATc1 pathway. Arch Oral Biol 2021; 122: 105029.
[http://dx.doi.org/10.1016/j.archoralbio.2020.105029] [PMID: 33387850]
[34]
Liu YH, Mou X, Zhou DY, Zhou DY, Shou CM. Extraction of flavonoids from Chrysanthemum morifolium and antitumor activity in vitro. Exp Ther Med 2018; 15(2): 1203-10.
[PMID: 29399116]
[35]
Sultana B, Anwar F, Ashraf M. Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts. Molecules 2009; 14(6): 2167-80.
[http://dx.doi.org/10.3390/molecules14062167] [PMID: 19553890]
[36]
Xing X, Li D. Identification and quality assessment of chrysanthemum buds by CE fingerprinting. J Anal Methods Chem 2015; 2015: 517402.
[http://dx.doi.org/10.1155/2015/517402] [PMID: 26064777]
[37]
Sun H, Zhang T, Fan Q, et al. Identification of floral scent in chrysanthemum cultivars and wild relatives by gas chromatography-mass spectrometry. Molecules 2015; 20(4): 5346-59.
[http://dx.doi.org/10.3390/molecules20045346] [PMID: 25816078]
[38]
Zhang LN, Wang L, Shi ZQ, Li P, Li HJ. A metabolomic strategy based on integrating headspace gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry to differentiate the five cultivars of Chrysanthemum flower. RSC Advances 2018; 8(17): 9074-82.
[http://dx.doi.org/10.1039/C7RA13503C] [PMID: 35541849]
[39]
Xiao Z, Fan B, Niu Y, Wu M, Liu J, Ma S. Characterization of odor-active compounds of various Chrysanthemum essential oils by gas chromatography-olfactometry, gas chromatography-mass spectrometry and their correlation with sensory attributes. J Chromatogr B Analyt Technol Biomed Life Sci 2016; 1009-1010: 1009-10.
[40]
Li S-P, Zhao J, Chen L-X, Hu D-J, Xu W-F. Identification and determination of fructooligosaccharides in snow chrysanthemum (Coreopsis tinctoria nutt.). World J Tradit Chin Med 2021; 7(1): 78-85.
[http://dx.doi.org/10.4103/wjtcm.wjtcm_64_20]
[41]
Savych A, Polonets O, Morozova L, Syrovatko K, Recun T. HPLC-FLD analysis of amino acids content in Chrysanthemum morifolium. Pharmacia 2022; 69(2): 337-43.
[http://dx.doi.org/10.3897/pharmacia.69.e82097]
[42]
Meusel I, Neinhuis C, Markstädter C, Barthlott W. Chemical composition and recrystallization of epicuticular waxes: Coiled rodlets and tubules. Plant Biol 2000; 2(4): 462-70.
[http://dx.doi.org/10.1055/s-2000-5961]
[43]
Haller HL. LaFORGE FB. Constituents of pyrethrum flowers. IV. The semicarbazones of pyrethrins I and II and of pyrethrolone. J Org Chem 1936; 1(1): 38-51.
[http://dx.doi.org/10.1021/jo01230a004]
[44]
Mutiah R, Marsyah A, Saputra AF. Systematic Review: Phytochemical content and pharmacological effects of chrysanthemum sp. Proc Int Pharm Ulul Albab Conf Semin 2021; 1.
[http://dx.doi.org/10.18860/planar.v1i0.1457]
[45]
Gui M, Du J, Guo J, Xiao B, Yang W, Li M. Aqueous extract of Chrysanthemum morifolium (Jú Huā) enhances the antimelanogenic and antioxidative activities of the mixture of soy peptide and collagen peptide. J Tradit Complement Med 2014; 4(3): 171-6.
[http://dx.doi.org/10.4103/2225-4110.128897] [PMID: 25161922]
[46]
Lee HJ, Kim MJ, Park JH, Park EJ. Antioxidative and antigenotoxic activity of white and yellow Chrysanthemum morifolium ramat extracts. J Korean Society Food Sci Nutrition 2012; 41(3): 289-94.
[http://dx.doi.org/10.3746/jkfn.2012.41.3.289]
[47]
Amrani A, Mecheri A, Bensouici C, et al. Evaluation of antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of Chrysanthemum fontanesii flowers and leaves extracts. Biocatal Agric Biotechnol 2019; 20: 101209.
[http://dx.doi.org/10.1016/j.bcab.2019.101209]
[48]
Chen M, Wang K, Zhang Y, et al. New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting α-glucosidase and the PTP-1B signaling pathway. Eur J Med Chem 2019; 178: 108-15.
[http://dx.doi.org/10.1016/j.ejmech.2019.05.083] [PMID: 31176093]
[49]
Gong Y, Guo Y, Zhang W. Protective effect of chrysanthemum extract against retinal light damage in mice. Recent Adv Ophthalmol 2021; 41(2): 110-5.
[50]
Yamamoto J, Tadaishi M, Yamane T, Oishi Y, Shimizu M, Kobayashi-Hattori K. Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice. Biosci Biotechnol Biochem 2015; 79(7): 1147-54.
[http://dx.doi.org/10.1080/09168451.2015.1008975] [PMID: 25665595]
[51]
Gong Y, Wang X, Wang Y, Hao P, Wang H, Guo Y, et al. The effect of a chrysanthemum water extract in protecting the retina of mice from light damage. BMC Complement Med Ther 2022; 22(1): 224.
[http://dx.doi.org/10.1186/s12906-022-03701-2]
[52]
Kalia R, Katnoria JK, Nagpal AK. Antitumor activity of aqueous leaf extracts of different cultivars of Chrysanthemum morifolium R. using potato disc tumor assay. J Pharm Sci Res 2016; 8(11): 1262-5.
[53]
Kruawan K, Kangsadalampai K. Antioxidant activity, phenolic compound contents and antimutagenic activity of some water extract of herbs. Thaiphesatchasan 2006; 30: 28-35.
[54]
Miyazawa M, Hisama M. Antimutagenic activity of flavonoids from Chrysanthemum morifolium. Biosci Biotechnol Biochem 2003; 67(10): 2091-9.
[http://dx.doi.org/10.1271/bbb.67.2091] [PMID: 14586095]
[55]
Burlec AF, Cioanca O, Mircea C, Arsene C, Tuchilus C, Corciovă A, et al. Antioxidant and antimicrobial properties of chrysanthemum and tagetes selective extracts. Farmacia 2019; 67(3): 405-10.
[http://dx.doi.org/10.31925/farmacia.2019.3.4]
[56]
Marchyshyn S, Polonets O, Tkachuk N, Nakonechna S, Harnyk M, Yurkiv V. Study of antimicrobial effect of chrysanthemum×hortorum bailey pectoral variety flowers and leaves. Pharmacologyonline 2021; 3: 1957-65.
[57]
Sassi AB, Harzallah-Skhiri F, Bourgougnon N, Aouni M. Antimicrobial activities of four tunisian chrysanthemum species. Indian J Med Res 2008; 127(2): 183-92.
[PMID: 18403798]
[58]
Boukhebti H, Demirtas I, Omar L, Chaker AN. Chemical composition, antibacterial activity of essential oil and anatomical study of Chrysanthemum morifolium. J Drug Deliv Ther 2020; 10(2-s): 7-13.
[http://dx.doi.org/10.22270/jddt.v10i2-s.4015]
[59]
Zhang Z, Pang X, Wei Y, Chen H, Jin X, Lv Q. Neuroprotective effects of Chrysanthemum morifolium on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway. Brain Inj 2022; 37(4): 269-81.
[PMID: 36567616]
[60]
Ma D, Wako Y. Evaluation of phenolic compounds and neurotrophic/neuroprotective activity of cultivar extracts derived from Chrysanthemum morifolium flowers. Food Sci Technol Res 2017; 23(3): 457-67.
[http://dx.doi.org/10.3136/fstr.23.457]
[61]
Kim IS, Koppula S, Park PJ, et al. Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. J Ethnopharmacol 2009; 126(3): 447-54.
[http://dx.doi.org/10.1016/j.jep.2009.09.017] [PMID: 19770030]
[62]
Kim IS, Ko HM, Koppula S, Kim BW, Choi DK. Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson’s disease. Food Chem Toxicol 2011; 49(4): 963-73.
[http://dx.doi.org/10.1016/j.fct.2011.01.002] [PMID: 21219959]
[63]
Jung TW, Lee JY, Shim WS, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Biochem Biophys Res Commun 2006; 343(2): 564-70.
[http://dx.doi.org/10.1016/j.bbrc.2006.02.186] [PMID: 16554029]
[64]
Mehboob Z, Sharif S, Lodhi MS, Zaigham K. In vitro study to evaluate the anticancer potential of chrysanthemum indicum, therapeutic plant. Pak-Euro J Med Life Sci 2022; 5(1): 12.
[65]
Yang L, Wei DD, Chen Z, Wang JS, Kong LY. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine 2011; 18(8-9): 710-8.
[http://dx.doi.org/10.1016/j.phymed.2010.11.017] [PMID: 21306883]
[66]
Lestari NA, Irawati S, Listiyana A, et al. Anticancer activities and metabolite fingerprinting of uplc-qtof-ms/ms method from chrysanthemum cinerariifolium (Trev). J Islamic Pharma 2019; 4(1): 19.
[http://dx.doi.org/10.18860/jip.v4i1.7728]
[67]
Ma D, Kanisha Chelliah C, Alharbi NS, et al. Chrysanthemum morifolium extract mediated Ag NPs improved the cytotoxicity effect in A549 lung cancer cells. J King Saud Univ Sci 2021; 33(1): 101269.
[http://dx.doi.org/10.1016/j.jksus.2020.101269]
[68]
Li Y, Yang P, Luo Y, et al. Chemical compositions of chrysanthemum teas and their anti-inflammatory and antioxidant properties. Food Chem 2019; 286: 8-16.
[http://dx.doi.org/10.1016/j.foodchem.2019.02.013] [PMID: 30827670]
[69]
Yang WS, Kim D, Yi YS, et al. AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens. J Ethnopharmacol 2017; 201: 82-90.
[http://dx.doi.org/10.1016/j.jep.2017.03.001] [PMID: 28274893]
[70]
Kim B, Kim HS. Chrysanthemum zawadskii extract activates peroxisome proliferator-activated receptor-α and has an anti-inflammatory activity: Potential interest for the skin barrier function. Korean J Chem Eng 2014; 31(10): 1831-8.
[http://dx.doi.org/10.1007/s11814-014-0109-0]
[71]
Lee S, Jang G, Jung J, et al. Memory-improving activity of the flower extract from Chrysanthemum boreale (makino) maskino in scopolamine-treated rodents. Processes 2023; 11(1): 159.
[http://dx.doi.org/10.3390/pr11010159]
[72]
Yoon YP, Lee HJ, Kim YH, Luyen BTT, Hong JH, Lee CJ. Effects of cynaroside, cynarin and linarin on secretion, production and gene expression of airway MUC5AC mucin in NCI-H292 cells. Nat Prod Sci 2015; 21(1): 59-65.
[73]
Chen L, Sun J, Pan Z, et al. Analysis of chemical constituents of chrysanthemum morifolium extract and its effect on postprandial lipid metabolism in healthy adults. Molecules 2023; 28(2): 579.
[http://dx.doi.org/10.3390/molecules28020579] [PMID: 36677639]
[74]
Hanyang L, Xuanzhe L, Xuyang C, et al. Application of zebrafish models in inflammatory bowel disease. Front Immunol 2017; 8: 501.
[http://dx.doi.org/10.3389/fimmu.2017.00501] [PMID: 28515725]
[75]
Kimberlin DW, Whitley RJ. Antiviral therapy of HSV-1 and-2. In: human herpesviruses Biology, Therapy, and Immunoprophylaxis. 2007; pp. 1153-74.
[http://dx.doi.org/10.1017/CBO9780511545313.065]
[76]
Bonifácio BV, dos Santos Ramos MA, da Silva PB, Bauab TM. Antimicrobial activity of natural products against Helicobacter pylori: A review. Ann Clin Microbiol Antimicrob 2014; 13(1): 54.
[PMID: 25406585]
[77]
Kim KJ, Lee Y, Son SR, et al. Water extracts of hull-less waxy barley (hordeum vulgare l.) cultivar ‘boseokchal’ inhibit rankl-induced osteoclastogenesis. Molecules 2019; 24(20): 3735.
[http://dx.doi.org/10.3390/molecules24203735] [PMID: 31623242]
[78]
Oh KW, Kim JW, Han JY, Hong JT, Li R, Eun JS. Ethanol extract of the flower Chrysanthemum morifolium augments pentobarbitalinduced sleep behaviors: Involvement of Cl-channel activation. Evidence-based Complement Altern Med 2011; 2011: 109164.
[http://dx.doi.org/10.1155/2011/109164] [PMID: 21331373]
[79]
Gao T, Zhu ZY, Zhou X, Xie ML. Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy in rats by reduction of blood pressure and inhibition of myocardial hypoxia inducible factor-1alpha expression. Pharm Biol 2016; 54(12): 2895-900.
[http://dx.doi.org/10.1080/13880209.2016.1190764] [PMID: 27268080]
[80]
Mahrous EA, Farag MA. Two dimensional NMR spectroscopic approaches for exploring plant metabolome: A review. J Adv Res 2015; 6(1): 3-15.
[http://dx.doi.org/10.1016/j.jare.2014.10.003] [PMID: 25685540]
[81]
Zhang Y, Yin HN, Zhao T, et al. The volatile flavor and the antioxidant properties of a novel chrysanthemum rice wine during natural aging. Food Sci Nutr 2023; 11(5): 2382-92.
[http://dx.doi.org/10.1002/fsn3.3247] [PMID: 37181305]
[82]
Niu Y, Sun X, Xiao Z, Wang P, Wang R. Olfactory impact of terpene alcohol on terpenes aroma expression in chrysanthemum essential oils. Molecules 2018; 23(11): 2803.
[http://dx.doi.org/10.3390/molecules23112803] [PMID: 30380636]
[83]
Samal S, Mohanty RP, Mohanty PS, Giri MK, Pati S, Das B. Implications of biosensors and nanobiosensors for the eco-friendly detection of public health and agro-based insecticides: A comprehensive review. Heliyon 2023; 9(5): e15848.
[http://dx.doi.org/10.1016/j.heliyon.2023.e15848]
[84]
Zhu Z, Qian S, Lu X, Xu C, Wang Y, Zhang X, et al. Protective properties of the extract of chrysanthemum on patients with ischemic stroke. J Healthc Eng 2021; 2021: 3637456.
[85]
Xiao Z, Fan B, Niu Y, Liu J, Li J, Kong J. Analysis of flavor substances in chrysanthemum essential oils. J Chinese Inst Food Sci Technol 2018; 18(3)
[86]
Lin L, Gu Y, Sun Y, Cui H. Characterization of chrysanthemum essential oil triple-layer liposomes and its application against Campylobacter jejuni on chicken. Lebensm Wiss Technol 2019; 107: 16-24.
[http://dx.doi.org/10.1016/j.lwt.2019.02.079]
[87]
Choi KT, Kim JH, Cho HT, Lim SS, Kwak SS, Kim YJ. Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract. J Cosmet Dermatol 2016; 15(2): 162-8.
[http://dx.doi.org/10.1111/jocd.12211] [PMID: 26786567]
[88]
v R, Rajeshkumar S, Ezhilarasan D, T L. Antimicrobial and Cytotoxic Effect of Herbal Mouthwash Prepared Using Ethanolic Extract of Ficus benghalensis and stevia. J Compl Med Res 2022; 13(2): 102.
[http://dx.doi.org/10.5455/jcmr.2022.13.02.20]
[89]
Park S, Lee JB, Kang S. Topical application of Chrysanthemum indicum L. Attenuates the development of atopic dermatitis-like skin lesions by suppressing serum IgE levels, IFN-γ and IL-4 in Nc/Nga mice. Evidence-based Complement Altern Med 2012; 2012: 821967.
[90]
Singh A, Singh A, Singh P, Chakravarty A, Singh A, Singh P, et al. Insecticidal activity, toxicity, resistance and metabolism of pyrethroids. A review 2022; 7: 238-50.
[91]
Guo L, Zhang W, Li S, Ho CT. Chemical and nutraceutical properties of Coreopsis tinctoria. J Funct Foods 2015; 13: 11-20.
[http://dx.doi.org/10.1016/j.jff.2014.11.011]
[92]
Ataee S, Oliaee A, Nia H. The effects of the interior plants on the health and quality of the environment. Rev QUID 2017; 1(1): 1122-7.
[93]
Ryu R, Kwon EY, Choi JY, Shon JC, Liu KH, Choi MS. Chrysanthemum leaf ethanol extract prevents obesity and metabolic disease in diet-induced obese mice via lipid mobilization in white adipose tissue. Nutrients 2019; 11(6): 1347.
[http://dx.doi.org/10.3390/nu11061347] [PMID: 31208033]
[94]
Habib A, Zaghloul S. Effect of chemical, organic and bio-fertilization on growth and flowering of chrysanthemum frutescens plants. J Hortic Sci Ornam Plants 2012; 4(2): 186-94.
[95]
León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed collagen-sources and applications. Molecules 2019; 24(22): 4031.
[http://dx.doi.org/10.3390/molecules24224031]
[96]
Meutia Sari L, Mubarak Z, Keumala Sari D. Evaluation of clinical, histology, TNF-α and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel. F1000 Res 2023; 10: 623.
[97]
Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4: 177.
[http://dx.doi.org/10.3389/fphar.2013.00177] [PMID: 24454289]

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