Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume nine of the series brings together 7 reviews on a variety of natural products and sources along with a chapter on the basics of investigating antioxidant activity. Propolis and its key chemical constituents: a promising natural product in therapeutic applications Investigation of the effects of using omega-3 fatty acids on egg quality in functional egg production Quercetin, a flavonoid with remarkable anticancer activity Swertiamarin for the treatment of metabolic syndrome Overview of traditional uses, phytochemistry and pharmacology of Peganum harmala l. Investigation of measurement methods of antioxidant activity and involved mechanisms Recent progress on natural and synthetic flavanone and its derivatives Role of virgin coconut oil as a multiple health promoting functional oil

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 7 reviews: - Recent advances in copper-catalyzed heterocyclic syntheses - Application of modern green chemistry methods in the synthesis of quinolines, quinazolines and quinazolinones - Electroluminescence polymers-a review on synthesis by organic compounds - Multicomponent approach for the synthesis of xanthenes - From atoms to macromolecules: 100 years of polymer research - An overview of oxidizing and reducing agents in total synthesis - Amino acid-derived ionic liquids: novel biodegradable catalytic systems for green synthesis of heterocycles

Osteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcoma still presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells. This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and concise guide to the pathophysiology of the disease, while also introducing the reader to new therapies and materials (specifically chitosan, polyethyleneimine, poloxamers, poloxamines, and Pluronics®) used in the treatment process along with the aims of the experiments present subsequently. Next, the book documents the materials and methods used in developing polymeric micelles for delivering drugs to osteosarcoma sites. By explaining the basics of nanomedicine as a starting point, readers will understand how polymeric micelles act as facilitators of drug transport to cancer cells, and how one can synthesize a small stable micelle (by creating derivatives of base nanomaterials), capable of actively targeting osteosarcoma cells and overcoming multi-drug resistance. The chapter explains the synthesis and characterization techniques of the materials used to develop polymeric micelles. The results, a reflection of the conjugation of different experimental solutions initiated here, point to a modern route towards the search for a therapeutic solution for osteosarcoma. The simple, structured presentation coupled with relevant information on the subject of micelle-based nanotherapeutic drug delivery make this monograph an essential handbook for pharmaceutical scientists involved in the field of nanomedicine, drug delivery, cancer therapy and any researchers assisting specialists in clinical oncology for the treatment of osteosarcoma.

This technical reference covers information about modern nanocatalysts and their applications in organic syntheses, electrochemistry and nanotechnology. The objective of this book is to present a review of the development of nanocatalysts in the fields of organic synthesis and electroanalysis over the last few decades. It provides readers comprehensive, systematic and updated information about the relevant topics. The reader is introduced to nanocatalysts, with the following chapters delving into the different chemical reactions in which they are involved. The topics covered include: carbon-carbon coupling reactions, aryl and organic carbon hetero atom coupling reactions, oxidation-reduction reactions, photocatalysis, heterocyclic reactions and multicomponent catalysis. The concluding chapters cover applications of nanocatalysts in electrochemical synthesis and sensing. The thirteen chapters demonstrate the value of a variety of catalysts that are important in chemical engineering processes. Advanced Nanocatalysis for Organic Synthesis and Electroanalysis delivers a quick and accessible reference on advanced nanocatalysis for a broad range of readers which includes graduate, postgraduate and Ph. D. students of chemical engineering as well as faculty members, research and development (R&D) personnel working in the industrial chemistry sector.

Advanced Physical Chemistry Practical Guide aims to improve the student’s understanding of theory through practical experience and by facilitating experimental exercises. The book covers a wide range of areas from basic to advanced experiments including the calibration of instruments as well as the use of software for accurate computational quantum chemical calculations. This book is divided into four sections: part I - general introduction, calibration of glassware, instruments and precautions part II - experiments that have a simple theoretical background and classical methods part III - experiments that are associated with more advanced theory, and technique that require a greater degree of experimental skill and instrumentation part IV – investigative experiments relying on computers Covering all aspects of classical, advanced and computational chemistry experiments, Advanced Physical Chemistry Practical Guide will enable students to gain confidence in their ability to perform a physical chemistry experiment and to appreciate the value of an experimental approach towards the subject. Advanced Physical Chemistry Practical Guide is an essential handbook for students and teachers at advanced levels who seek to learn practical knowledge about important aspects of physical chemistry.

Advanced Techniques of Analytical Chemistry explains analytical chemistry in an accessible manner for students. The book provides basic and practical knowledge that helps the learner to understand the methods used in conducting experiments. Readers will understand the key concepts of qualitative and quantitative analysis through easy-to-read chapters written for chemistry students. Volume 1 covers the topic of volumetric analysis in detail. Topic-wise chapters introduce the reader to volumetric titrations and then explain the range of titration techniques which include aqueous acid-base titration, non-aqueous titration, redox titration, complexometric titration and some miscellaneous methods like diazotisation titration, Kjeldahl’s method and the oxygen flask combustion method. The combination of basic and advanced methods makes this an ideal textbook for chemistry students at graduate and undergraduate levels as well as an ideal handbook for the laboratory instructor.

Applications of Modern Mass Spectrometry, Volume 2, covers the latest advances in mass spectrometry in scientific research. The series presents readers with information on the broad range of mass spectrometry techniques and configurations, data analysis, and practical applications. Each volume contains contributions from eminent researchers who present their findings in an easy-to-read format. The multidisciplinary nature of the works presented in each volume of this book series makes it a valuable reference on mass spectrometry to academic researchers and industrial R&D specialists in applied sciences, biochemistry, life sciences, and allied fields. The second volume of the series presents 6 reviews: Ion Mobility-Mass Spectrometry for Macromolecule Analysis - Recent Advancements in Detection of Organic Contaminants in Wastewater Using Advanced Mass Spectrometry - Poisonous Substances in Tropical Medicinal and Edible Plants: Traditional Uses, Toxicology, and Characterization by Hyphenated Mass Spectrometry Techniques - LC-MS Analysis of Endogenous Neuropeptides from Tissues of Central Nervous System: An Overview - Advances in Structural Proteomics Using Mass Spectrometry and Recent Trends of Modern Mass Spectrometry: Application towards Drug Discovery and Development Process.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. Volume 11 of this series brings together reviews covering immunotherapy of sepsis, new antimalarials, and the medicinal use of onions for respiratory diseases, among other topics. Topics included in this volume are: - Heme-oxygenase and autophagy connected as a cytoprotective mechanism: potential therapeutic target - Development of recombinant therapeutic proteins in animal cells: Challenges and solutions - Artemisinin Analogues as a Novel Class of Antimalarial Agents: Recent Developments, Current Scenario and Future Perspectives - The effects of Allium cepa and their derivatives on respiratory diseases and the possible mechanisms of these effects - Immunotherapy of Sepsis

Beta-glucan is a polysaccharide and an important food supplement that strengthens the immune system. Beta-glucan can be obtained from many food sources such as mushrooms, yeast, or oats. Beta-glucan has a therapeutic use in the treatment of many diseases, thanks to its immune system strengthening effect. Its use helps curtail the need for administering high levels of antibiotics in case of serious infections. This book presents information about the medical applications of beta-glucan. Starting with an introduction to the basic biochemistry and classification of beta-glucan, the contents explain the readers about its use in treating a variety of medical conditions. These include cancer, allergies, COVID-19, respiratory tract infections, hypercholesterolemia, diabetes and many other other endocrinological, immunological and infectious diseases. This book is a comprehensive resource about the medical use of beta-glucan where any reader can find topical information and learn about recent studies on the therapeutic effects of beta-glucan on the treatment of different diseases.