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Review Article

治疗老年黄斑变性的药理进展

卷 27, 期 4, 2020

页: [583 - 598] 页: 16

弟呕挨: 10.2174/0929867326666190726121711

价格: $65

摘要

与年龄有关的黄斑变性是一种获得性的变性疾病，是导致老年人严重视力下降的原因。有两种类型：干性老年黄斑变性和湿性老年黄斑变性。它的处理已得到改进，并在将来尝试进行定制。这篇综述的目的是总结治疗与年龄有关的黄斑变性的药理学进展。对于干性AMD，尚无有效的治疗方法可降低其进展。然而，一些分子，如兰帕珠单抗和依库丽单抗，尽管疗效低下，但仍在研究中。在此，为了防止干燥的AMD进展，最重要的研究建议增加抗氧化剂的摄入并戒烟。另一方面，湿性AMD有更发达的治疗方法。如今，金标准治疗是抗VEGF注射。但是，目前正在研究更有效的分子。干AMD和湿AMD有不同的分子正在研究中。这个事实可以帮助我们用更有效，更持久的药物治疗患者，但是需要更多的临床试验和安全性研究才能达到最佳治疗效果。

关键词: 年龄有关黄斑变性，脉络膜新生血管，药理学，血管内皮生长因子，分子，治疗。

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