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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Pharmacological Advances in the Treatment of Age-related Macular Degeneration

Author(s): María Gil-Martínez, Paz Santos-Ramos, Maribel Fernández-Rodríguez , Maximino J. Abraldes, Maria José Rodríguez-Cid, María Santiago-Varela, Anxo Fernández-Ferreiro* and Francisco Gómez-Ulla *

Volume 27, Issue 4, 2020

Page: [583 - 598] Pages: 16

DOI: 10.2174/0929867326666190726121711

Price: $65

Abstract

Age-related macular degeneration is an acquired degenerative disease that is responsible for severe loss of vision in elderly people. There are two types: dry age-related macular degeneration and wet age-related macular degeneration. Its treatment has been improved and tries to be tailored in the future. The aim of this review is to summarize the pharmacological advances in the treatment of age-related macular degeneration. Regarding dry AMD, there is no effective treatment to reduce its progression. However, some molecules such as lampalizumab and eculizumab were under investigation, although they have shown low efficacy. Herein, in an attempt to prevent dry AMD progression, the most important studies suggested increasing the antioxidants intake and quitting the smoke habit. On the other hand, wet AMD has more developed treatment. Nowadays, the gold standard treatment is anti-VEGF injections. However, more effective molecules are currently under investigation. There are different molecules under research for dry AMD and wet AMD. This fact could help us treat our patients with more effective and lasting drugs but more clinical trials and safety studies are required in order to achieve an optimal treatment.

Keywords: Age-related macular degeneration, choroidal neovascularization, pharmacology, vascular endothelial growth factor, molecules, treatment.

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