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Current Molecular Medicine

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Review Article

BRAF Status in Papillary Microcarcinomas of the Thyroid Gland: a Brief Review

Author(s): Antonio Ieni*, Roberto Vita, Roberta Cardia , Giuseppe Giuffré, Salvatore Benvenga and Giovanni Tuccari

Volume 19, Issue 9, 2019

Page: [665 - 672] Pages: 8

DOI: 10.2174/1566524019666190717161359

Price: $65

Abstract

Papillary thyroid microcarcinoma (PTMC) is defined by the World Health Organization as papillary cancer measuring 10 mm or less in diameter. Generally, PTMC shows an indolent clinical behavior with a good prognosis, although a minority of PTMC is characterized by an aggressive course. However, efforts to identify this aggressive subset of PTMC after surgery remain inconclusive.

Several oncogenic pathways have been identified in thyroid cancer and have been applied translationally to improve prognosis and clinical management. In particular, the BRAFV600E mutation was found more frequently in large, aggressive, recurrent and advanced tumors.

We aimed at reviewing studies on BRAFV600E mutation as a prognostic factor in PTMC.

Keywords: Thyroid papillary microcarcinoma, cancer, prognosis, BRAF, mutation.

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