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Review Article

纳米医学-联合免疫治疗癌症

卷 27, 期 34, 2020

页: [5716 - 5729] 页: 14

弟呕挨: 10.2174/0929867326666190618161610

价格: $65

摘要

背景：肿瘤的免疫治疗包括嵌合抗原受体(CAR)-T细胞、CAR-自然杀伤细胞(NK)、PD1和PD-L1抑制剂。然而，对癌症免疫治疗有反应的患者比例并不令人满意。与此同时，纳米技术在癌症诊断和治疗方面也经历了一场革命。虽然许多治疗性纳米载体已被批准用于临床应用，但很少有临床批准的纳米颗粒能够选择性地结合和靶向癌细胞并结合分子。目前还没有关于纳米医学和免疫疗法如何联合应用于治疗癌症的系统综述。 目的：这篇综述旨在说明纳米医学和免疫疗法如何能够用于癌症治疗，以克服对癌症免疫治疗有反应的患者比例低和临床使用纳米材料稀少的局限性。 方法：对MEDLINE、PubMed / PubMed Central和谷歌学术进行了文献综述。我们对有关纳米颗粒药物给药系统的文献进行了结构化检索，包括光动力疗法、光热疗法、光声疗法和免疫疗法。此外，我们详细介绍了各种纳米粒子与分子结合的优缺点，以讨论与癌症治疗相关的挑战和解决方案。 结论：本综述确定了与改善卫生保健和结果相关的优势和劣势。这篇综述的发现证实了纳米药物联合免疫疗法对提高癌症治疗效果的重要性。利用纳米材料实现协同抗肿瘤免疫可能成为开发新型癌症治疗方法的新途径。

关键词: 肿瘤免疫治疗，CAR- NK细胞，药物传递，纳米药物，协同效应，CAR-T细胞

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