Title:The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran
Volume: 20
Issue: 2
Author(s): Seyedeh H. Sharami, Mahboobeh Gholipour, Forozan Milani, Ehsan Kazemnejad, Seyedeh F.D. Heirati and Zahra A. Ranjbar*
Affiliation:
- Department of Endocrinology and Metabolism, Reproductive Health Research center, Guilan University of Medical Sciences, Rasht,Iran
Keywords:
Dyslipidemia, preterm birth, women, pregnancy, triglycerides, Iran, prospective cohort study.
Abstract:
Background: Dyslipidemia is recognized as an important factor in the incidence of Preterm
Birth (PTB). The early diagnosis of factors affecting PTB is important in the reduction of maternalneonatal
complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB
in women from the Guilan province of Iran.
Methods: The current investigation was a prospective cohort study on 378 pregnant women in Rasht
city (Guilan province), during 2018-2019. Samples were randomly selected among pregnant women
who referred to Al-Zahra hospital. Association of the lipid profiles: Total Cholesterol (TC), High-
Density Lipoprotein (HDLC), Low-Density Lipoprotein (LDLC), and Triglycerides (TG) with PTB
was assessed using the Chi-square, Fisher tests and logistic regression analysis.
Results: Our findings showed that of the evaluated lipid profiles, TG and TC had the highest predictive
power with AUC =0.833 (95٪, CI: 0.736-0.930) and 0.772 (95%, CI: 0.676-0.867), respectively; also,
their sensitivity and specificity were 83.3%, 70.2% and 83.3%, 66.1%, respectively. Moreover, abnormal
LDL concentrations increase the risk of PTB by two folds (P < 0.05).
Conclusion: It seems that by controlling the lipid profiles of pregnant women, the risk of PTB could
be reduced.
