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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Zanthoxylum: A Review of its Traditional Uses, Naturally Occurring Constituents and Pharmacological Properties

Author(s): Zulfa Nooreen, Sudeep Tandon, Narayan P. Yadav, Prabhat Kumar, Tran D. Xuan and Ateeque Ahmad*

Volume 23, Issue 12, 2019

Page: [1307 - 1341] Pages: 35

DOI: 10.2174/1385272823666190528072011

Price: $65

Open Access Journals Promotions 2
Abstract

Zanthoxylum, commonly known as Timoor, has been used in different traditional systems of medicine and also for several other applications such as chemopreventive agents, tooth care, as spices, condiments, etc. Due to the pungent taste of fruits, seeds, leaves, bark, and therapeutic remedies, especially in Indian system of medicine, Eastern Asian countries and in Central America, it is being substituted for pepper. The collection of Zanthoxylum armatum DC; Syn. Z. alatum Roxb and its several species used for food, medicine and barter has been a part of the culture of many communities in different countries. The fruits and seeds of timoor are well known in ayurvedic medicine and used for different diseases. The bark of the plant has also been reported for hepatoprotective activity. Several natural compounds have been isolated and identified in several classes, from different plant parts and species. The Zanthoxylum compounds and extracts of the plant parts have been reported for several types of biological activities. This review aims to examine the detailed aspects of phytochemical compounds and pharmacological activities covering maximum species of this genus. In view of the available pharmacological data and traditional use in Indian system of medicine and in other countries also, Z. armatum and other species certainly deserve more investigations. However, clinical evidence and rigorous investigations for quality control are required before any recommendation for Zanthoxylum based products.

Keywords: Zanthoxylum spp., Timoor, Nepali Dhania, chemopreventive, spice, Rutaceae, Biological activities.

Graphical Abstract
[1]
Thomas, V.; Grant, R. Sappi tree spotting: Highlands: Highveld, drakensberg, eastern cape mountains, johannesburg: Jacana. Jacana Media., 2011, 3, 160.
[2]
Wilbur, C.; Keith, M.D. Revolutionary medicine. Globe Pequot Press, 1980, 23, 1700-1800.
[3]
Bharadwaj, M. Indian spice kitchen. Hippocrene Books. Monisha, 2006, 978, 82-83.
[4]
Peter, K.V. Handbook of herbs and spices Woodhead Publishing; , 2004, 978, pp. 98-99.
[5]
Alam, F.; Us Saqib, Q.N. Renata, Pascon, C.; Marcelo, A.; Vallim, M.A. Chemical composition and in vitro cytotoxic and antimicrobial activities of the essential oil from leaves of Z. monogynum st. hill (rutaceae). Medicines (Basel), 2017, 4, 2-8. [http://dx.doi.org/10.3390/medicines4020031].
[6]
Hebind, P.K.; Gautam, S.D.; Jha, R.N. GC-MS analysis of hexane extract of Z. armatum DC. Fruits. J Pharmacogn Phytochem., 2016, 5, 58-62.
[7]
Alam, F.; Us Saqib, Q.N. Evaluation of Zanthoxylum armatum Roxb for in vitro biological activities. J. Tradit. Complement. Med., 2017, 7(4), 515-518. [http://dx.doi.org/10.1016/j.jtcme.2017.01.006]. [PMID: 29034201].
[8]
Sugai, E.; Morimitsu, Y.; Kubota, K. Quantitative analysis of sanshool compounds in Japanese pepper (Xanthoxylum piperitum DC.) and their pungent characteristics. Biosci. Biotechnol. Biochem., 2005, 69(10), 1958-1962. [http://dx.doi.org/10.1271/bbb.69.1958]. [PMID: 16244448].
[9]
Ishimatsu, Y.; Moritaki, J.; Fujinaga, K. Oral cavity cleaning composition comprising extract of plant belonging to genus Zanthoxylum of family Rutaceae 1988, 63048208-19880229.
[10]
Zhu, R.; Zeng, W.; Zhao, Z.; Gao, H. Chemical components and antibacterial activity of hanyuan Z. bungeanum seed oil. Shipin Kexue, 2011, 32, 85-88.
[11]
Chang, soo, Y.; Suk, LinIm Studies on the constituents of Z. coreanum, nakai. kor. J. Pharmacogn., 1987, 18, 75.
[12]
Achar, S. Devasthale.; Badarinarayan, S. Dentifrice composition having improved anti-sensitivity property. Indian Patent, , DE01785- A20160708. July 08 2016.
[13]
Barkatullah, B.B.; Ibrar, M.; Ali, N.; Muhammad, N. Antispasmodic potential of leaves, barks and fruits of Z. armatum DC. Afr. J. Pharm. Pharmacol., 2013, 7, 685-693.
[14]
Davide, C.; Enrico, G. Composition for lensitive cream made of joint use of Zanthoxylum armatum extract. Italy Patent, IT, 1420214, B1. January 05, 2016
[15]
Zhong, Y. Cockroach attraction bait. Faming Zhuanli Shenqing Patent CN 106305830A January 11, 2017.
[16]
Zha, X.; Zha, C.J.; Zha, X. Guangsheng sesame oil containing angelica sinensis and capable of expelling wind and cold. Faming zhuanli shenqing Patent CN 106172880A, December 07, 2016.
[17]
Sharma, N.; Dubey, N.; Kumar, S. To evaluate marketed herbal tooth powders with antimicrobial and antioxidant activity. World J. Pharm. Sci., 2016, 5, 1473-1491.
[18]
Naru, H. A kind of traditional Chinese medicine for treating toothache. Faming Zhuanli Shenqing Patent CN 106038782A, October 26, 2016.
[19]
Traditional Chinese medicine composition for treatment of thyroid cancer and preparation method Faming Zhuanli Shenqing Patent CN 105853754A, August 18, 2016.
[20]
Devasthale, S.S.; Badarinarayan, S. Dentifrice composition having improved anti-sensitivity property achar. Indian Patent,2013DE01785 A, July 08, 2016.
[21]
Zhang, T. Traditional Chinese medicine composition for treating tinea pedis. Faming Zhuanli Shenqing Patent CN 105560776 A, November 05, , 2016.
[22]
Mukhija, M.; Lal Dhar, K.; Nath Kalia, A. Bioactive Lignans from Zanthoxylum alatum Roxb, stem bark with cytotoxic potential. J. Ethnopharmacol., 2014, 152(1), 106-112. [http://dx.doi.org/10.1016/j.jep.2013.12.039]. [PMID: 24412550].
[23]
Gaya, C.H.; Kawaka, J.F.; Muchugi, A. Variation of alkaloids in the Kenyan Z. gilletii (De Wild Waterman) and Ngeranwa. Afr. J. Plant Sci., 2013, 7, 438-444. [http://dx.doi.org/10.5897/AJPS2013.1008].
[24]
Huang, C.F.; Wang, L.F. Cytotoxicity of benzophenanthridine alkaloids from the roots of Z. nitidum (Roxb.) DC. var. fastuosum how ex huang. Nat. Prod. Res., 2015, 29, 1478-6419.
[25]
Hua, J.; Zhang, W.D.; Liua, R.H.; Zhang, C.; Shen, Y.H.; Li, H.L.; Liang, M.J.; Xu, X.K. Benzophenanthridine alkaloids from Z. nitidum (Roxb.) DC, and their tnalgesic and anti-inflammatory activities. Chem. Biodivers., 2006, 3, 990-995. [http://dx.doi.org/10.1002/cbdv.200690108]. [PMID: 17193331].
[26]
Runyoro, D.K.B.; Ngassapa, O.D.; Masimba, P.; Peter, B. Antimicrobial activity of Z. holtizianum (Engl.) waterm and Z. lindense (Engl.) kokwaro growing in bagamoyo district, coast region, Tanzania. J. Pharm. Sci. Res., 2017, 9, 49-54.
[27]
Wang, Y. Medicine for treating pediatric hip joint hydrops. Faming Zhuanli Shenqing Patent CN 105031282-A, November 11,, 2015.
[28]
Song, C.; Song, J.; Song, Y.; Chen, W.; Zhou, R. Traditional chinese medicine preparation method for treating and repairing skin wound-induced scar and its manufacture method. Faming Zhuanli Shenqing Patent, September 25, 2013.
[29]
Kyoung, S.B. Pharmaceutical composition for treating alcoholic hepatitis and preparation method thereof. Faming Zhuanli Shenqing Patent CN 106822588 A, July 13, 2017.
[30]
Hu, W.; Zhong, Z. Preparation of health care pillows filled with traditional Chinese medicine for treating insomania. Faming Zhuanli Shenqing Patent CN 101015410 A, August 15, , 2007.
[31]
Lin, Hao Feng, Zechuan.; Zhang, Yunping.; Chen, Xuesong.; Huang, Xinhui. A kind of rp-hplc determination of two Chinese herbal medicine. Faming Zhuanli Shenqing Patent CN 107085050A, August 22,, 2017.
[32]
Xia, F. Chinese medicine pill with good effects of treating traumatic injury and removing blood stasis and preparation method thereof. Faming Zhuanli Shenqing Patent CN 107050183 A, August 18, 2017.
[33]
Lin, H.; Feng, Z.; Zhang, Y.; Chen, H.X. A toothpaste determination method of the content of nitidine chloride. Faming Zhuanli Shenqing Patent CN 106970167 A, July 21,, 2017.
[34]
Montagnani, C.; Gentili, R.; Citterio, S.; Galasso, G. Z. Armatum (Rutaceae) a new invasive species in Italy. Conference: 111 Congresso della Società Botanica Italiana, III Int. Plant Sci. Confer, 2006.
[35]
Huang, N. A kind of traditional Chinese medicine for treating toothache. Faming Zhuanli Shenqing patent CN 106038782 A, October 26,, 2016.
[36]
Ma, Y.; Yun, K.; Li, Y.; Tong, Y.; Hao, X.; Liu, L.; Che, Y.; Fang, F. Traditional chinese medicine compound composition for treating pain and joint activities not smooth induced by wind cold evil invasion of the body and the production method and application thereof. Faming Zhuanli Shenqing Patent CN 104800620 A, July 29, 2015.
[37]
Peng, Y.; He, J.; Xiong, G.; Liu, M.; Zhang, J.A. Plant mosquito-repellent agent for repelling culex fatigans, preparation method and application. Faming Zhuanli Shenqing Patent CN 105961453 A, September 28, 2016.
[38]
Nooreen, Z.; Singh, S. Singh, Kumar, D.; Tandon, S.; Ahmad, A. Luqman S. Characterization and evaluation of bioactive polyphenolic constituents from Z. armatum DC. A traditionally used plant. Biomed. Pharmacother., 2017, 89, 366-375. [http://dx.doi.org/10.1016/j.biopha.2017.02.040]. [PMID: 28242546].
[39]
Kanwal, R.; Arshad, M.; Bibi, Y.; Asif, S.; Chaudhari, S.K. Evaluation of ethnopharmacological and antioxidant potential of Z. armatum DC. J. Chem., 2015, 925654/1-925654/8.
[40]
Upadhyaya, K. Ashok.; Kumar, P. Concentration dependent antioxidant activity of Z. armatum. J. Pharm. Res., 2010, 3, 1581-1582.
[41]
Brijwal, L.; Pandey, A.; Tamta, S. An overview on phytomedicinal approaches of Z. armatum DC: An important magical medicinal plant. J. Med. Plants Res., 2013, 7, 366-370.
[42]
Prieto, J.A.; Patiño, O.J.; Delgado, W.A.; Moreno, J.P.; Cuca, L.E. Chemical composition, insecticidal, and antifungal activities of fruit essential oils of three colombian Zanthoxylum species. Chil. J. Agric. Res., 2011, 71, 73-82. [http://dx.doi.org/10.4067/S0718-58392011000100009].
[43]
Nguyen, Q.A.; Van-Dufat, H.T.; Michel, S.; Tillequin, F.; Dumontet, V.; Sévenet, T. A new phenylpropanoid ester from the bark of Zanthoxylum scandens (Rutaceae). Z. Natforsch. C J. Biosci., 2002, 57(11-12), 986-989. [http://dx.doi.org/10.1515/znc-2002-11-1205]. [PMID: 12562081].
[44]
Cheng, M.J.; Lee, K.H.; Tsai, I.L.; Chen, I.S. Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorg. Med. Chem., 2005, 13(21), 5915-5920. [http://dx.doi.org/10.1016/j.bmc.2005.07.050]. [PMID: 16140017].
[45]
Cheng, M.J.; Tsai, I.L.; Chen, I.S. Chemical constituents from the root bark of formosan Z. ailanthoides, J. Chin. Chem. Soc-Taip., 2003, 50, 1241-1246.
[46]
Bhatt, V.; Sharma, S.; Kumar, N.; Sharma, U.; Singh, B. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. J. Pharm. Biomed. Anal., 2017, 132, 46-55. [http://dx.doi.org/10.1016/j.jpba.2016.09.035]. [PMID: 27693952].
[47]
Guo, T.; Dai, L.P.; Tang, X.F.; Song, T.T.; Wang, Y.; Zhao, A.H.; Cao, Y.Y.; Chang, J. Two new phenolic glycosides from the stem of Zanthoxylum armatum D.C. Nat. Prod. Res., 2017, 31(20), 2335-2340. [http://dx.doi.org/10.1080/14786419.2017.1303695]. [PMID: 28322075].
[48]
Zhongguo, Z.; Xinxi, Z. Simultaneous determination of the contents of dictamnolactone and skimmianine in root of Z. armatum DC. from Gansu Province by HPLC. J. Tradit. Chin. Med., 2015, 22, 91-93.
[49]
Samad, A.; Adeel, M.; Khan, D.; Badshah, P.P.; Muhammad, S. Two new bioactive furoquinoline alkaloids from Z. armatum. Asian J. Chem., 2015, 27(7), 2468-2472. [http://dx.doi.org/10.14233/ajchem.2015.17931].
[50]
Barkatullah, Ibrar M.; Muhammad, N.; Innayat, U.R.; Mujeeb, U.R.; Khan, A. Chemical composition and biological screening of essential oils of Z. armatum DC leaves. Clin. Toxicol., 2013, 3, 1000172/1- 1000172/6.
[51]
Bisht, M.; Mishra, D.; Sah, M.L.; Joshi, S.; Mishra, S. Biological activities of the essential oil of Z. armatum DC. leaves. Nat. Prod. J., 2014, 4, 229-232. [http://dx.doi.org/10.2174/2210315504666141111231606].
[52]
Guleria, S.; Tiku, A.K.; Koul, A.; Gupta, S.; Singh, G.; Razdan, V.K. Antioxidant and antimicrobial properties of the essential oil and extracts of Zanthoxylum alatum grown in north-western Himalaya. Sci. World, J, 2013, 10, 790-580. [http://dx.doi.org/10.1155/2013/790580]. [PMID: 23781160].
[53]
Bachwani, M.; Shrivastava, B.; Sharma, V.; Khandelwal, R.; Tomar, L. An update review on Z. armatum DC. Am. J. Pharm.Tech. Res, 2012, 2, 274-286.
[54]
Epifano, F.; Curini, M.; Marcotullio, M.C.; Genovese, S. Searching for novel cancer chemopreventive plants and their products: The genus Zanthoxylum. Curr. Drug Targets, 2011, 12, 1895-1902. [http://dx.doi.org/10.2174/138945011798184128]. [PMID: 21158710].
[55]
Akhtar, N.; Ali, M.; Alam, M.S. Chemical constituents from the seed of Z. armatum. J. Asian Nat. Prod. Chem, 2009, 1, 91-95. [http://dx.doi.org/10.1080/10286020802514622].
[56]
Chen, I.S.; Chen, L.; Chang, Y.L.; Teng, C.M.; Lin, W.Y. Chemical constituents and biological activities of the fruit of Z. integrifoliolum. Nat. Prod, 1999, 62, 833-837.
[57]
Sati, S.C.; Sati, M.D.; Raturi, R.; Badoni, P.; Sing, H. Anti-inflammatory and antioxidant activity of zanthoxylum armatum stem bark. J. Gen. Eng, 2011, 11.
[58]
Yamazaki, E.; Nagaki, M.; Kurita, O.; Inoue, T. Antioxidant activity of Japanese pepper (Z. piperitum DC.) fruit. Food Sci, 2007, 100, 171-177.
[59]
Zhang, Y.; Wang, D.; Yang, L.; Zhou, D. Purification and characterization of flavonoids from the leaves of Z. bungeanum and correlation between their structure and antioxidant activity. PLOS ONE,, 2014, 9, e105725/1- 11.
[60]
Bowen, J.M.; Cole, R.J.; Bedell, D.; Schabdach, D. Neuromuscular effects of toxins isolated from southern prickly ash (Z. clava-herculis) bark. Am. J. Vet. Res., 1996, 57, 1239-1244. [PMID: 8836382].
[61]
Ross, S.A.; Krishnaveni, K.S.; Burandt, C.L. Two new benzofuran derivatives from the roots of Z. flavum. J. Chem. Res., 2006, 406-407. [http://dx.doi.org/10.3184/030823406777946716].
[62]
Gong, Y.; Huang, Y.; Zhou, L.; Shi, X.; Guo, Z.; Wang, M.; Jiang, W. Chemical composition and antifungal activity of the fruit oil of Z. bungeanum Maxim, (Rutaceae). J. Essent. Oil Res., 2009, 21, 174-178. [http://dx.doi.org/10.1080/10412905.2009.9700141].
[63]
Zhou, J.J.; Ren, Y.Q.; Lei, Q.Y.; Kexue, S. Chemical composition and antioxidant activities of the essential oil from leaves of Z. ailanthoides Sieb. Et Zucc. Food Sci, 2014, 35, 137-141.
[64]
Negi, J.S.; Bisht, V.K. Bhandari1, A.K.; Singh, P.; Sundriyal, R.C. Chemical constituents and biological activities of the genus Zanthoxylum: A review. African J. Pure Applied Chem., 2011, 5, 412-416.
[65]
Zhang, W.J.; Guo, S.S.; You, C.X.; Geng, Z.F.; Liang, J.Y. Chemical composition of essential oils from Z. bungeanum maxim and their bioactivities against lasioderma serricorne. J. Oleo Sci., 2016, 65, 871-879.
[66]
Munoz, M.A.; Torres, R.; Cassels, B.K. Aurapten and flindersine from Z. coco. J. Nat. Prods, 1982, 45, 367-369. [http://dx.doi.org/10.1021/np50021a023].
[67]
Nogueira, J.; Mourao, S.C.; Dolabela, I.B.; Santos, M.G.; Mello, C.B.; Kelecom, A.; Mexas, R.; Feder, D.; Fernandes, C.P.; Gonzalez, M.S. Z. caribaeum (rutaceae) essential oil: Chemical investigation and biological effects on rhodnius prolixus nymph. J. Parasitol. Res., 2014, 113, 4271-4279.
[68]
Bodede, O.; Shaik, S.; Singh, M.; Moodley, R. Phytochemical analysis with antioxidant and cytotoxicity studies of the bioactive principles from Z. capense (small knobwood). Med. Chem. Res., 2017, 17, 627-634.
[69]
Luo, X.; Pires, D.; Ainsa, J.A.; Begona, G.; Duarte, N.; Mulhovo, S.; Anes, E.; Ferreira, M.U. Z. capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages. J. Ethnopharmacol., 2013, 146, 417-422.
[70]
Babu, B.R.; Khurana, S.; Sakhuja, R.; Srivastava, A.K. A new flavone glycoside from Z. acanthopodium DC. Indian J. Chem., 2007, 46, 872-874.
[71]
Mashimbye, M.J.; Maumela, M.C.; Raphulu, M.C. The X-ray structure and the 13C NMR data of chelerythrine acetonate from Z. davyi, C. Niger. J. Nat. Prod. Med., 2000, 4, 57-61.
[72]
Seoposengwe, K.; Tonder, J.J.; Steenkamp, V. In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells. BMC Complement. Altern. Med., 2013, 13, 353.
[73]
Tarus, P.K.; Coombes, P.H.; Crouch, N.R.; Mulholland, D.A. Benzo [c] phenanthridine alkaloids from stem bark of the forest knobwood, Z. davyi (rutaceae). S. Afr. J. Bot., 2006, 72, 555-558. [http://dx.doi.org/10.1016/j.sajb.2006.03.014].
[74]
Fish, F.; Gray, A.I.; Waterman, P.G.; Donachie, F. Alkaloids and coumarins from North American Zanthoxylum species. Lloydia, 1975, 38, 268-270.
[75]
Kalia, N.K.; Singh, B.; Sood, R.P. A new amide from Z. armatum. J. Nat. Prod., 1999, 62, 311-312.
[76]
Yang, Z.D.; Zhang, D.B.; Ren, J.; Yang, M.J. Skimmianine, a furoquinoline alkaloid from Z. nitidum as a potential acetylcholinesterase inhibitor. Med. Chem. Res., 2012, 21, 722-725.
[77]
Carpinella, M.C.; Andrione, D.G.; Ruiz, G.; Palacios, S.M. Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina. Phytother. Res., 2010, 24, 259-263.
[78]
Mansoor, T.A.; Borralho, P.M.; Luo, X.; Mulhovo, S. 6-Acetonyldi-hydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 colon cancer cells. J. Nat. Prod., 2014, 77, 1825-1830. [http://dx.doi.org/10.1021/np500161n]. [PMID: 25066282].
[79]
Cao, X.L.; Xu, J.; Bai, G.; Zhang, H.; Liu, Y.; Xiang, J.F.; Tang, Y.L. Isolation of anti-tumor compounds from the stem bark of Z. ailanthoides sieb. & zucc. by silica gel column and counter-current chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2013, 929, 6-10. [http://dx.doi.org/10.1016/j.jchromb.2013.04.006]. [PMID: 23660246].
[80]
Ibrar, M.; Muhammad, N. Antinociceptive and anticonvulsant activities of essential oils of Z. armatum. Phytopharmacol, 2012, 3, 191-198.
[81]
Medhi, K.; Deka, M.; Bhau, B.S. The genus zanthoxylum: A stockpile of biological and ethnomedicinal properties.scient. Sci. Rep., 2013, 2, 1-8.
[82]
Lee, Y.J.; Kao, E.S.; Chu, C.Y.; Lin, W.L.; Chiou, Y.H.; Tseng, T.H. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol. Rep., 2006, 16, 921-927.
[83]
Chung, Y.C.; Chien, C.T.; Teng, K.Y.; Chou, S.T. Antioxidative and mutagenic properties of Z. ailanthoides Sieb and zucc. Food Chem., 2006, 97, 418-425.
[84]
Zhu, R.X.; Wei, K.Z.; Zeng, W.C. Chemical components and antibacterial activity of hanyuan Z. bungeanum. Afr. J. Microbiol. Res., 2011, 5, 4631-4637.
[85]
Yook, C.S.; Kim, C.M.; Shin, E.T. Studies on the constituents of Z. coreanum nakai, yook. Saengyak Hakhoe chi, 1987, 18, 180-183.1.
[86]
Marquez, L.; Aguero, J.; Hernandez, I.; Garrido, G.; Martinez, I.; Dieguez, R. Anti-inflammatory evaluation and phytochemical characterization of some plants of the Zanthoxylum genus. Acta Farm Bonaer, 2005, 24, 325-330.
[87]
Huang, N. A kind of traditional Chinese medicine for treating toothache. Faming Zhuanli Shenqing patent CN 106038782 A, October 26,, 2016.
[88]
Jacquelyn, A.; Stermitz, F.R. Constituents of Zanthoxylum. Part 4. Bishordeninyl terpene alkaloids and other constituents of Z. culantrillo and Z. coriaceum, Swinehart. Phytochemistry, 1980, 19, 1219-1223. [http://dx.doi.org/10.1016/0031-9422(80)83087-1].
[89]
Facundo, V.A.; Pinto, A.S.; Braz, F.R. Pinto, Angelo, C.; Rezende, C.M. Chemical constituents of Z. ekmanii (urb.) alain. Quim. Nova, 2005, 28, 224-225.
[90]
Cabral, V.; Luo, X.; Junqueira, E.; Costa, S.; Mulhovo, S.; Duarte, A.; Couto, I. Enhancing activity of antibiotics against staphylococcus aureus: Z. capense constituents and derivatives. Phytomedicine, 2015, 22, 469-476. [http://dx.doi.org/10.1016/j.phymed.2015.02.003]. [PMID: 25925969].
[91]
Teenkamp, V.; Fernandes, A.C. Antibacterial activity of venda medicinal plants. Fitoterapia, 2007, 78, 561-564.
[92]
Samuel, J.M.; Pickles, S.S. The Constituents of west Indian satinwood, auld. J. Chem. Soc., 1912, 101, 1052-1060. [http://dx.doi.org/10.1039/CT9120101052].
[93]
Mukhija, M.; Dhar, K.L.; Kalia, A.N. Bioactive lignans from Z. alatum roxb. stem bark with cytotoxic potential. J. Ethnopharmacol., 2014, 152, 106-112.
[94]
Tomko, J.; Awad, A.T.; Beal, J.L.; Doskotch, R.W. Constituents of Z. martinicense. Lloydia, 1967, 30, 231-235.
[95]
Allison, L. Phytochemical profile and biological activity evaluation of Z. heterophyllum leaves against malaria. Planta Med. Lett, 2015, 12, e10-e11.
[96]
Gilani, S.N.; Khan, A.U.; Gilani, A.H. Pharmacological basis for the medicinal use of Z. armatum in gut, airways and cardiovascular disorders. Phytother. Res., 2010, 24, 553-558. [PMID: 20041426].
[97]
Semenya, S.; Maroyi, A.; Potgieter, M.; Erasmus, L. Herbal medicines used by Bapedi traditional healers to treat reproductive ailments in the Limpopo Province. South Africa. Afr. J. Tradit. Complement. Altern. Med., 2013, 10, 331-339. [PMID: 24146458].
[98]
Li, K.; Zhou, R. Wang, Jia, W.; Li, Z.; Li, J.; Zhang, P.; Xiao, T. Z. bungeanum essential oil induces apoptosis of HaCaT human keratinocytes. J. Ethnopharmacol., 2016, 186, 351-361.
[99]
Mexas, R.; Feder, D.; Fernandes, C.P. Z. caribaeum (Rutaceae) essential oil: Chemical investigation and biological effects on Rhodnius prolixus nymph. J. Parasitol. Res., 2014, 113, 4271-4279.
[100]
Song, L.; Shen, G. Plaster for treating pain and preparation method thereof. Faming Zhuanli Shenqing patent CN 105126010 A., December 13. 2015.
[101]
Le, V.H.; Le, T.T.; Ngo, X.L.; Nguyen, X.D. Study on chemical components of leaves of Z. nitidum DC. collected at thanh hoa province. Tap. Chi. Duoc Hoc, 2005, 45, 7-9.
[102]
Zhou, T.; Pu, B.; Jiang, HX.; Deng, Y.Q. Study on the antioxidant activities of Z. armatum DC Prodr.Oil. Shipin gongye keji., 2014, 35, 58-62.
[103]
Ranawat, L.; Bhatt, J.; Patel, J. Hepatoprotective activity of ethanolic extracts of bark of Z. armatum DC in CCl4 induced hepatic damage in rats. J. Ethnopharmacol., 2010, 127, 777-780. [http://dx.doi.org/10.1016/j.jep.2009.10.019]. [PMID: 19874881].
[104]
Hur, J.M.; Park, J.C.; Hwang, Y.H. Aromatic acid and flavonoids from the leaves of Z. piperitum. Nat. Prod. Res., 2017, 7, 23-26.
[105]
Eiter, L.C.; Fadamiro, H.; Setzer, W.N. Seasonal variation in the leaf essential oil composition of Z. clava-herculis growing in Huntsville, Alabama. Nat. Prod. Commun., 2010, 5, 457-460. [http://dx.doi.org/10.1177/1934578X1000500323]. [PMID: 20420327].
[106]
Chung, C.Y.; Hwang, T-L.; Kuo, L.M.; Kuo, W.L.; Cheng, M.J. New benzo [c] phenanthridine and benzenoid derivatives and other constituents from Z. ailanthoides: Effects on neutrophil pro-inflammatory responses. Int. J. Mol. Sci., 2013, 14, 22395-22408. [http://dx.doi.org/10.3390/ijms141122395]. [PMID: 24232457].
[107]
Nooreen, Z.; Kumar, A.; Bawankule, D.U.; Tandon, S.; Ali, M.; Xuan, T.D.; Ahmad, A. New chemical constituents from the fruits of Z. armatum and its in vitro antiinflammatory profile. Nat. Prod. Res., 2019, 33(5), 665-672. [http://dx.doi.org/10.1080/14786419.2017.1405404].
[108]
Singh, T.P.; Singh, O.M. Phytochemical and pharmacological profile of Z. armatum DC. Indian J. Nat. Prod. Resour., 2011, 2, 275-285.
[109]
Ozkan, M.; Mutiso, P.B.C.; Nahar, L.; Sarker, S. Z. Usambarense (Engl.) kokwaro (Rutaceae) extracts inhibit the growth of the breast cancer cell Lines MDA-MB-231 and MCF-7, but not the brain tumour cell line U251 in vitro. Phytother. Res., 2013, 27, 787-790.
[110]
Diéguez-Hurtado, G.; Garrido-Garrido, S.; Prieto-González, Y. Antifungal activity of some cuban Zanthoxylum species. Fitoterpapia, 2003, 74, 384-386.

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