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Current Vascular Pharmacology

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ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

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Review Article

Advanced Glycation End Products in Chinese Medicine Mediated Aging Diseases: A Review

Author(s): Wenqian Zhang, Tingting Zhao, Yonghua Zhao, Dingkun Gui and Youhua Xu*

Volume 18, Issue 4, 2020

Page: [322 - 333] Pages: 12

DOI: 10.2174/1570161117666190507112157

Price: $65

Abstract

Aging has become a worldwide problem. During this process, the incidence of related diseases such as diabetes and atherosclerosis increases dramatically. Studies within the most recent two decades suggest a pivotal role of Advanced Glycation End Products (AGEs) in the aging process. This review aims to systemically summarize the effects and potential mechanism of Chinese Medicines on inhibiting AGEs-related aging diseases.

Keywords: Aging, advanced glycation end products, Chinese medicines, vascular diseases, diabetes, Alzheimer's disease.

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[1]
Harper S. Economic and social implications of aging societies. Science 2014; 346(6209): 587-91.
[http://dx.doi.org/10.1126/science.1254405] [PMID: 25359967]
[2]
Lin RY, Choudhury RP, Cai W, et al. Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 2003; 168(2): 213-20.
[http://dx.doi.org/10.1016/S0021-9150(03)00050-9] [PMID: 12801603]
[3]
Oya T, Hattori N, Mizuno Y, et al. Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts. J Biol Chem 1999; 274(26): 18492-502.
[http://dx.doi.org/10.1074/jbc.274.26.18492] [PMID: 10373458]
[4]
Srikanth V, Maczurek A, Phan T, et al. Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease. Neurobiol Aging 2011; 32(5): 763-77.
[http://dx.doi.org/10.1016/j.neurobiolaging.2009.04.016] [PMID: 19464758]
[5]
Kikuchi S, Shinpo K, Takeuchi M, et al. Glycation--a sweet tempter for neuronal death. Brain Res Brain Res Rev 2003; 41(2-3): 306-23.
[http://dx.doi.org/10.1016/S0165-0173(02)00273-4] [PMID: 12663085]
[6]
Baraibar MA, Liu L, Ahmed EK, Friguet B. Protein oxidative damage at the crossroads of cellular senescence, aging, and age-related diseases. Oxid Med Cell Longev 2012; 2012 919832
[http://dx.doi.org/10.1155/2012/919832] [PMID: 23125894]
[7]
Ou P, Wolff SP. Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro. Biochem Pharmacol 1993; 46(7): 1139-44.
[http://dx.doi.org/10.1016/0006-2952(93)90461-5] [PMID: 8216363]
[8]
Philis-Tsimikas A, Parthasarathy S, Picard S, Palinski W, Witztum JL. Aminoguanidine has both pro-oxidant and antioxidant activity toward LDL. Arterioscler Thromb Vasc Biol 1995; 15(3): 367-76.
[http://dx.doi.org/10.1161/01.ATV.15.3.367] [PMID: 7749847]
[9]
Skamarauskas JT, McKay AG, Hunt JV. Aminoguanidine and its pro-oxidant effects on an experimental model of protein glycation. Free Radic Biol Med 1996; 21(6): 801-12.
[http://dx.doi.org/10.1016/0891-5849(96)00183-9] [PMID: 8902526]
[10]
Hunt JV, Skamarauskas JT, Mitchinson MJ. Protein glycation and fluorescent material in human atheroma. Atherosclerosis 1994; 111(2): 255-65.
[http://dx.doi.org/10.1016/0021-9150(94)90100-7] [PMID: 7718028]
[11]
Kunkel HG, Wallenius G. New hemoglobin in normal adult blood. Science 1955; 122(3163): 288.
[http://dx.doi.org/10.1126/science.122.3163.288] [PMID: 13246634]
[12]
Losso JN, Bawadi HA, Chintalapati M. Inhibition of the formation of advanced glycation end products by thymoquinone. Food Chem 2011; 128(1): 55-61.
[http://dx.doi.org/10.1016/j.foodchem.2011.02.076] [PMID: 25214329]
[13]
Cerami C, Founds H, Nicholl I, et al. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci USA 1997; 94(25): 13915-20.
[http://dx.doi.org/10.1073/pnas.94.25.13915] [PMID: 9391127]
[14]
Goldberg T, Cai W, Peppa M, et al. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004; 104(8): 1287-91.
[http://dx.doi.org/10.1016/j.jada.2004.05.214] [PMID: 15281050]
[15]
Matsumoto T, Ozawa Y, Taguchi K, Kobayashi T, Kamata K. Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides 2010; 31(2): 346-53.
[http://dx.doi.org/10.1016/j.peptides.2009.11.029] [PMID: 19962413]
[16]
Koschinsky T, He CJ, Mitsuhashi T, et al. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 1997; 94(12): 6474-9.
[http://dx.doi.org/10.1073/pnas.94.12.6474] [PMID: 9177242]
[17]
Raina AK, Perry G, Nunomura A, Sayre LM, Smith MA. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clin Chem Lab Med 2000; 38(2): 93-7.
[http://dx.doi.org/10.1515/CCLM.2000.015] [PMID: 10834395]
[18]
Thornalley PJ. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Cell Mol Biol 1998; 44(7): 1013-23.
[PMID: 9846883]
[19]
Pricci F, Leto G, Amadio L, et al. Role of galectin-3 as a receptor for advanced glycosylation end products. Kidney Int Suppl 2000; 77: S31-9.
[http://dx.doi.org/10.1046/j.1523-1755.2000.07706.x] [PMID: 10997688]
[20]
Schmidt AM, Vianna M, Gerlach M, et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 1992; 267(21): 14987-97.
[PMID: 1321822]
[21]
Araki N, Higashi T, Mori T, et al. Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction. Eur J Biochem 1995; 230(2): 408-15.
[http://dx.doi.org/10.1111/j.1432-1033.1995.0408h.x] [PMID: 7607209]
[22]
Miyazaki A, Nakayama H, Horiuchi S. Scavenger receptors that recognize advanced glycation end products. Trends Cardiovasc Med 2002; 12(6): 258-62.
[http://dx.doi.org/10.1016/S1050-1738(02)00171-8] [PMID: 12242049]
[23]
Edelstein D, Brownlee M. Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes 1992; 41(1): 26-9.
[http://dx.doi.org/10.2337/diab.41.1.26] [PMID: 1727735]
[24]
Soulis-Liparota T, Cooper ME, Dunlop M, Jerums G. The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat. Diabetologia 1995; 38(4): 387-94.
[http://dx.doi.org/10.1007/BF00410275] [PMID: 7796978]
[25]
Kern TS, Engerman RL. Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin. Diabetes 2001; 50(7): 1636-42.
[http://dx.doi.org/10.2337/diabetes.50.7.1636] [PMID: 11423486]
[26]
Yagihashi S, Kamijo M, Baba M, Yagihashi N, Nagai K. Effect of aminoguanidine on functional and structural abnormalities in peripheral nerve of STZ-induced diabetic rats. Diabetes 1992; 41(1): 47-52.
[http://dx.doi.org/10.2337/diab.41.1.47] [PMID: 1727739]
[27]
Taguchi T, Sugiura M, Hamada Y, Miwa I. In vivo formation of a Schiff base of aminoguanidine with pyridoxal phosphate. Biochem Pharmacol 1998; 55(10): 1667-71.
[http://dx.doi.org/10.1016/S0006-2952(98)00010-0] [PMID: 9634003]
[28]
Chen AS, Taguchi T, Aoyama S, et al. Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine. Free Radic Biol Med 2003; 35(11): 1392-403.
[http://dx.doi.org/10.1016/j.freeradbiomed.2003.08.014] [PMID: 14642387]
[29]
Rojas A, Delgado-López F, González I, Pérez-Castro R, Romero J, Rojas I. The receptor for advanced glycation end-products: a complex signaling scenario for a promiscuous receptor. Cell Signal 2013; 25(3): 609-14.
[http://dx.doi.org/10.1016/j.cellsig.2012.11.022] [PMID: 23200851]
[30]
Liu Y, Liang C, Liu X, et al. AGEs increased migration and inflammatory responses of adventitial fibroblasts via RAGE, MAPK and NF-kappaB pathways. Atherosclerosis 2010; 208(1): 34-42.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.007] [PMID: 19959167]
[31]
Northcott JM, Czubryt MP, Wigle JT. Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction. Can J Physiol Pharmacol 2017; 95(10): 1067-77.
[http://dx.doi.org/10.1139/cjpp-2017-0149] [PMID: 28727928]
[32]
Jakus V, Rietbrock N. Advanced glycation end-products and the progress of diabetic vascular complications. Physiol Res 2004; 53(2): 131-42.
[PMID: 15046548]
[33]
Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997; 99(3): 457-68.
[http://dx.doi.org/10.1172/JCI119180] [PMID: 9022079]
[34]
Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia 2001; 44(2): 129-46.
[http://dx.doi.org/10.1007/s001250051591] [PMID: 11270668]
[35]
Vlassara H, Brownlee M, Cerami A. Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo. Diabetes 1988; 37(4): 456-61.
[http://dx.doi.org/10.2337/diab.37.4.456] [PMID: 2837419]
[36]
Jono T, Miyazaki A, Nagai R, Sawamura T, Kitamura T, Horiuchi S. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Lett 2002; 511(1-3): 170-4.
[http://dx.doi.org/10.1016/S0014-5793(01)03325-7] [PMID: 11821070]
[37]
Yim MB, Yim HS, Lee C, Kang SO, Chock PB. Protein glycation: creation of catalytic sites for free radical generation. Ann N Y Acad Sci 2001; 928: 48-53.
[http://dx.doi.org/10.1111/j.1749-6632.2001.tb05634.x] [PMID: 11795527]
[38]
Sobal G, Menzel J, Sinzinger H. Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study. Prostaglandins Leukot Essent Fatty Acids 2000; 63(4): 177-86.
[http://dx.doi.org/10.1054/plef.2000.0204] [PMID: 11049692]
[39]
Zheng Q, Huang YY, Zhu PC, et al. Ligustrazine exerts cardioprotection in animal models of myocardial ischemia/reperfusion injury: preclinical evidence and possible mechanisms. Front Pharmacol 2018; 9: 729.
[http://dx.doi.org/10.3389/fphar.2018.00729] [PMID: 30090062]
[40]
Zhang C, Teng F, Tu J, Zhang D. Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury. PLoS One 2014; 9(11) e113673
[http://dx.doi.org/10.1371/journal.pone.0113673] [PMID: 25409029]
[41]
Lei Y, Yang J, Zhao H. [Experimental study on extracts from ginseng, notoginseng and chuanxiong for delaying vascular aging in senescent mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010; 30(9): 946-51.
[PMID: 21179735]
[42]
Pashikanti S, de Alba DR, Boissonneault GA, Cervantes-Laurean D. Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products. Free Radic Biol Med 2010; 48(5): 656-63.
[http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.019] [PMID: 19969069]
[43]
Khajevand-Khazaei MR, Mohseni-Moghaddam P, Hosseini M, Gholami L, Baluchnejadmojarad T, Roghani M. Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. Eur J Pharmacol 2018; 833: 307-13.
[http://dx.doi.org/10.1016/j.ejphar.2018.06.019] [PMID: 29920283]
[44]
Ozturk H, Cetinkaya A, Yilmaz F, Ozturk H. Protective effect of oxymatrine against renal ischemia/reperfusion injury in rats. Bratisl Lek Listy 2017; 118(4): 217-22.
[http://dx.doi.org/10.4149/BLL_2017_043] [PMID: 28471232]
[45]
Zi XH, Zhou W, Chen Q, Li M, Gu SL. [The effect of oxymatrine on aging mice caused by D+ -galactose]. Zhong Yao Cai 2012; 35(9): 1455-9.
[PMID: 23451502]
[46]
Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 2008; 88(11): 1322-35.
[http://dx.doi.org/10.2522/ptj.20080008] [PMID: 18801863]
[47]
Rojas A, Morales MA. Advanced glycation and endothelial functions: a link towards vascular complications in diabetes. Life Sci 2004; 76(7): 715-30.
[http://dx.doi.org/10.1016/j.lfs.2004.09.011] [PMID: 15581904]
[48]
Meek RL, LeBoeuf RC, Saha SA, et al. Glomerular cell death and inflammation with high-protein diet and diabetes. Nephrol Dial Transplant 2013; 28(7): 1711-20.
[http://dx.doi.org/10.1093/ndt/gfs579] [PMID: 23314315]
[49]
Simonson MS. Phenotypic transitions and fibrosis in diabetic nephropathy. Kidney Int 2007; 71(9): 846-54.
[http://dx.doi.org/10.1038/sj.ki.5002180] [PMID: 17342177]
[50]
Chiang CK, Wang CC, Lu TF, et al. Involvement of endoplasmic reticulum stress, autophagy, and apoptosis in advanced glycation end products-induced glomerular mesangial cell injury. Sci Rep 2016; 6: 34167.
[http://dx.doi.org/10.1038/srep34167] [PMID: 27665710]
[51]
Yu J, Wu H, Liu ZY, Zhu Q, Shan C, Zhang KQ. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. Int J Mol Med 2017; 40(4): 1185-93.
[http://dx.doi.org/10.3892/ijmm.2017.3098] [PMID: 28849106]
[52]
Makita Z, Radoff S, Rayfield EJ, et al. Advanced glycosylation end products in patients with diabetic nephropathy. N Engl J Med 1991; 325(12): 836-42.
[http://dx.doi.org/10.1056/NEJM199109193251202] [PMID: 1875967]
[53]
Makita Z, Bucala R, Rayfield EJ, et al. Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure. Lancet 1994; 343(8912): 1519-22.
[http://dx.doi.org/10.1016/S0140-6736(94)92935-1] [PMID: 7911868]
[54]
Yacoub R, Nugent M, Cai W, et al. Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial. PLoS One 2017; 12(9) e0184789
[http://dx.doi.org/10.1371/journal.pone.0184789] [PMID: 28931089]
[55]
Galler A, Müller G, Schinzel R, Kratzsch J, Kiess W, Münch G. Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and nepsilon-(carboxymethyl)lysine ELISA. Diabetes Care 2003; 26(9): 2609-15.
[http://dx.doi.org/10.2337/diacare.26.9.2609] [PMID: 12941727]
[56]
Stitt AW. The role of advanced glycation in the pathogenesis of diabetic retinopathy. Exp Mol Pathol 2003; 75(1): 95-108.
[http://dx.doi.org/10.1016/S0014-4800(03)00035-2] [PMID: 12834631]
[57]
Yamagishi S, Amano S, Inagaki Y, et al. Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes. Biochem Biophys Res Commun 2002; 290(3): 973-8.
[http://dx.doi.org/10.1006/bbrc.2001.6312] [PMID: 11798169]
[58]
Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H. The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. J Biol Chem 2000; 275(33): 25781-90.
[http://dx.doi.org/10.1074/jbc.M001235200] [PMID: 10829018]
[59]
Chen G, Chen X, Niu C, et al. Baicalin alleviates hyperglycemia-induced endothelial impairment 1 via Nrf2. J Endocrinol 2018; 240(1): 81-98.
[PMID: 30400057]
[60]
Motomura K, Fujiwara Y, Kiyota N, et al. Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. J Agric Food Chem 2009; 57(17): 7666-72.
[http://dx.doi.org/10.1021/jf9007168] [PMID: 19681610]
[61]
Xu Y, Xiong J, Zhao Y, et al. Calycosin rebalances advanced glycation end products-induced glucose uptake dysfunction of hepatocyte in vitro. Am J Chin Med 2015; 43(6): 1191-210.
[http://dx.doi.org/10.1142/S0192415X15500688] [PMID: 26446203]
[62]
Xu YH, Xiong J, Wang SS, Tang D, Wang RS, Zhu Q. Calycosin entered HUVECs and ameliorated AGEs-promoted cell apoptosis via the Bcl-2 pathway. J Nat Med 2014; 68(1): 163-72.
[http://dx.doi.org/10.1007/s11418-013-0787-7] [PMID: 23797737]
[63]
Xu Y, Feng L, Wang S, et al. Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration. J Ethnopharmacol 2011; 137(1): 359-70.
[http://dx.doi.org/10.1016/j.jep.2011.05.041] [PMID: 21669275]
[64]
Xu Y, Feng L, Wang S, et al. Phytoestrogen calycosin-7-O-β-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. J Cell Biochem 2011; 112(10): 2953-65.
[http://dx.doi.org/10.1002/jcb.23212] [PMID: 21647942]
[65]
Chen Y, Gui D, Chen J, He D, Luo Y, Wang N. Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats. Cell Physiol Biochem 2014; 33(6): 1975-87.
[http://dx.doi.org/10.1159/000362974] [PMID: 25012492]
[66]
Qiu YY, Tang LQ, Wei W. Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy. Mol Cell Endocrinol 2017; 443: 89-105.
[http://dx.doi.org/10.1016/j.mce.2017.01.009] [PMID: 28087385]
[67]
Hao M, Li SY, Sun CK, et al. Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. Eur J Pharmacol 2011; 654(3): 320-5.
[http://dx.doi.org/10.1016/j.ejphar.2010.12.030] [PMID: 21236251]
[68]
Pu C, Yang YB, Sun QL. [Effects of Salvia miltiorrhiza on oxidative stress and microinflammatory state in patients undergoing continuous hemodialysis]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2006; 26(9): 791-4.
[PMID: 17058827]
[69]
Chen J, Zhao D, Zhu M, et al. Paeoniflorin ameliorates AGEs-induced mesangial cell injury through inhibiting RAGE/mTOR/autophagy pathway. Biomed Pharmacother 2017; 89: 1362-9.
[http://dx.doi.org/10.1016/j.biopha.2017.03.016] [PMID: 28320103]
[70]
Tang NY, Liu CH, Hsieh CT, Hsieh CL. The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats. Am J Chin Med 2010; 38(1): 51-64.
[http://dx.doi.org/10.1142/S0192415X10007786] [PMID: 20128044]
[71]
Liu Z, Lv Y, Zhang Y, et al. Matrine-type alkaloids inhibit advanced glycation end products induced reactive oxygen species-mediated apoptosis of aortic endothelial cells in vivo and in vitro by targeting MKK3 and p38MAPK signaling. J Am Heart Assoc 2017; 6(12) e007441
[http://dx.doi.org/10.1161/JAHA.117.007441] [PMID: 29197828]
[72]
Xu B, Ji Y, Yao K, Cao YX, Ferro A. Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: relevance to diabetes. Clin Sci (Lond) 2005; 109(5): 439-46.
[http://dx.doi.org/10.1042/CS20050183] [PMID: 16022682]
[73]
Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 2017; 16(1): 68.
[http://dx.doi.org/10.1186/s12937-017-0293-y] [PMID: 29020971]
[74]
Qin R, Zhang J, Li C, et al. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Arch Pharm Res 2012; 35(7): 1241-50.
[http://dx.doi.org/10.1007/s12272-012-0715-5] [PMID: 22864747]
[75]
Lu Y, Du Y, Qin L, et al. Gypenosides altered hepatic bile acids homeostasis in mice treated with high fat diet. Evid Based Complement Alternat Med 2018; 2018 8098059
[http://dx.doi.org/10.1155/2018/8098059] [PMID: 30105069]
[76]
Zeng L, Ding H, Hu X, Zhang G, Gong D. Galangin inhibits α-glucosidase activity and formation of non-enzymatic glycation products. Food Chem 2019; 271: 70-9.
[http://dx.doi.org/10.1016/j.foodchem.2018.07.148] [PMID: 30236734]
[77]
Yamabe N, Kang KS, Matsuo Y, Tanaka T, Yokozawa T. Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats. Biol Pharm Bull 2007; 30(7): 1289-96.
[http://dx.doi.org/10.1248/bpb.30.1289] [PMID: 17603169]
[78]
Zhao M, Qian D, Shang EX, et al. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats. J Ethnopharmacol 2015; 173: 280-6.
[http://dx.doi.org/10.1016/j.jep.2015.07.037] [PMID: 26231452]
[79]
Lv X, Dai G, Lv G, et al. Synergistic interaction of effective parts in Rehmanniae Radix and Cornus officinalis ameliorates renal injury in C57BL/KsJ-db/db diabetic mice: Involvement of suppression of AGEs/RAGE/SphK1 signaling pathway. J Ethnopharmacol 2016; 185: 110-9.
[http://dx.doi.org/10.1016/j.jep.2016.03.017] [PMID: 26972502]
[80]
Kim J, Jo K, Lee IS, Kim CS, Kim JS. The extract of aster koraiensis prevents retinal pericyte apoptosis in diabetic rats and its active compound, chlorogenic acid inhibits age formation and age/rage interaction. Nutrients 2016; 8(9) E585
[http://dx.doi.org/10.3390/nu8090585] [PMID: 27657123]
[81]
Hu S, Wu Y, Zhao B, et al. Panax notoginseng saponins protect cerebral microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway. Molecules 2018; 23(11) E2781
[http://dx.doi.org/10.3390/molecules23112781] [PMID: 30373188]
[82]
Gui D, Wei L, Jian G, Guo Y, Yang J, Wang N. Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo. Cell Physiol Biochem 2014; 34(6): 1849-62.
[http://dx.doi.org/10.1159/000366384] [PMID: 25503068]
[83]
Zhou P, Lu S, Luo Y, et al. Attenuation of TNF-α-induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-κB, JNK and p38 signaling pathways. Front Pharmacol 2017; 8: 464.
[http://dx.doi.org/10.3389/fphar.2017.00464] [PMID: 28824425]
[84]
Smith MA, Taneda S, Richey PL, et al. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci USA 1994; 91(12): 5710-4.
[http://dx.doi.org/10.1073/pnas.91.12.5710] [PMID: 8202552]
[85]
Pamplona R, Dalfó E, Ayala V, et al. Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets. J Biol Chem 2005; 280(22): 21522-30.
[http://dx.doi.org/10.1074/jbc.M502255200] [PMID: 15799962]
[86]
Dei R, Takeda A, Niwa H, et al. Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer’s disease. Acta Neuropathol 2002; 104(2): 113-22.
[http://dx.doi.org/10.1007/s00401-002-0523-y] [PMID: 12111353]
[87]
Castellani RJ, Harris PL, Sayre LM, et al. Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radic Biol Med 2001; 31(2): 175-80.
[http://dx.doi.org/10.1016/S0891-5849(01)00570-6] [PMID: 11440829]
[88]
Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005; 15(7): 16R-28R.
[http://dx.doi.org/10.1093/glycob/cwi053] [PMID: 15764591]
[89]
Tohgi H, Utsugisawa K, Nagane Y, Yoshimura M, Ukitsu M, Genda Y. Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (RAGE) gene in autopsy human cortex. Brain Res Mol Brain Res 1999; 65(1): 124-8.
[http://dx.doi.org/10.1016/S0169-328X(98)00351-9] [PMID: 10036314]
[90]
Li J, Feng L, Xing Y, et al. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. Int J Mol Sci 2014; 15(4): 5928-39.
[http://dx.doi.org/10.3390/ijms15045928] [PMID: 24722566]
[91]
Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem 2005; 280(45): 37377-82.
[http://dx.doi.org/10.1074/jbc.M508246200] [PMID: 16162502]
[92]
Tang Y, Chen A. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Lab Invest 2014; 94(5): 503-16.
[http://dx.doi.org/10.1038/labinvest.2014.42] [PMID: 24614199]
[93]
Duran-Jimenez B, Dobler D, Moffatt S, et al. Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes. Diabetes 2009; 58(12): 2893-903.
[http://dx.doi.org/10.2337/db09-0320] [PMID: 19720799]
[94]
Shen LR, Xiao F, Yuan P, et al. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Age (Dordr) 2013; 35(4): 1133-42.
[http://dx.doi.org/10.1007/s11357-012-9438-2] [PMID: 22653297]
[95]
Jing G, Zhang M. Oxidative stress damage and therapy for diabetic encephalopathy. Chin J Diabetes 2011; 19(1): 68-70.
[96]
Pan C, Lou L, Huo Y, et al. Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. Ther Adv Cardiovasc Dis 2011; 5(2): 99-111.
[http://dx.doi.org/10.1177/1753944710396538] [PMID: 21282198]
[97]
Nakashima K, Miyashita H, Yoshimitsu H, Fujiwara Y, Nagai R, Ikeda T. Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products. J Nat Med 2016; 70(2): 290-5.
[http://dx.doi.org/10.1007/s11418-015-0962-0] [PMID: 26758618]
[98]
Lin W, Wang W, Wang D, Ling W. Quercetin protects against atherosclerosis by inhibiting dendritic cell activation. Mol Nutr Food Res 2017; 61(9) 1700031
[http://dx.doi.org/10.1002/mnfr.201700031] [PMID: 28457022]
[99]
Kook D, Wolf AH, Yu AL, et al. The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci 2008; 49(4): 1712-20.
[http://dx.doi.org/10.1167/iovs.07-0477] [PMID: 18385095]
[100]
Li B, Yang M, Liu JW, Yin GT. Protective mechanism of quercetin on acute myocardial infarction in rats. Genet Mol Res 2016; 15(1) 15017117
[http://dx.doi.org/10.4238/gmr.15017117] [PMID: 26985950]
[101]
Lin Y, Liu HL, Fang J, Yu CH, Xiong YK, Yuan K. Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats. Food Chem Toxicol 2014; 68: 290-6.
[http://dx.doi.org/10.1016/j.fct.2014.03.026] [PMID: 24685824]
[102]
Singh J, Chaudhari BP, Kakkar P. Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation. Environ Toxicol Pharmacol 2017; 50: 67-75.
[http://dx.doi.org/10.1016/j.etap.2017.01.013] [PMID: 28135651]
[103]
Yang QY, Lai XD, Ouyang J, Yang JD. Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats. Toxicology 2018; 409: 144-51.
[http://dx.doi.org/10.1016/j.tox.2018.08.010] [PMID: 30144466]
[104]
Zhuang CL, Mao XY, Liu S, et al. Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats. Eur J Pharmacol 2014; 740: 480-7.
[http://dx.doi.org/10.1016/j.ejphar.2014.06.040] [PMID: 24975098]
[105]
Rastogi V, Santiago-Moreno J, Doré S. Ginseng: a promising neuroprotective strategy in stroke. Front Cell Neurosci 2015; 8: 457.
[http://dx.doi.org/10.3389/fncel.2014.00457] [PMID: 25653588]
[106]
Sun CD, Liang C, Wu Z, et al. Effects of Tongxinluo on survival of endothelial progenitor cells exposed to advanced glycation end products and the possible mechanism. Shanghai Med J 2008; 31(10): 711-4.
[107]
Sun K, Fan J, Han J. Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage. Acta Pharm Sin B 2015; 5(1): 8-24.
[http://dx.doi.org/10.1016/j.apsb.2014.11.002] [PMID: 26579420]
[108]
Kim HJ, Jung SW, Kim SY, et al. Panax ginseng as an adjuvant treatment for Alzheimer’s disease. J Ginseng Res 2018; 42(4): 401-11.
[http://dx.doi.org/10.1016/j.jgr.2017.12.008] [PMID: 30337800]
[109]
Liu Q, Qiao AM, Yi LT, Liu ZL, Sheng SM. Protection of kinsenoside against AGEs-induced endothelial dysfunction in human umbilical vein endothelial cells. Life Sci 2016; 162: 102-7.
[http://dx.doi.org/10.1016/j.lfs.2016.08.022] [PMID: 27567684]
[110]
Gou SH, Liu BJ, Han XF, et al. Anti-atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum mixture in high-fat emulsion- and vitamin D3-induced atherosclerotic rats. J Chin Med Assoc 2018; 81(5): 398-408.
[http://dx.doi.org/10.1016/j.jcma.2017.08.018] [PMID: 29107606]
[111]
Akinyemi AJ, Thomé GR, Morsch VM, et al. Effect of ginger and turmeric rhizomes on inflammatory cytokines levels and enzyme activities of cholinergic and purinergic systems in hypertensive rats. Planta Med 2016; 82(7): 612-20.
[http://dx.doi.org/10.1055/s-0042-102062] [PMID: 27002391]
[112]
Wang Y, Zhao M, Wang M, Zhao C. Profiling analysis of amino acids from hyperlipidaemic rats treated with Gynostemma pentaphyllum and atorvastatin. Pharm Biol 2016; 54(10): 2254-63.
[http://dx.doi.org/10.3109/13880209.2016.1152278] [PMID: 26958976]
[113]
Milić N, Milosević N, Golocorbin Kon S, Bozić T, Abenavoli L, Borrelli F. Warfarin interactions with medicinal herbs. Nat Prod Commun 2014; 9(8): 1211-6.
[http://dx.doi.org/10.1177/1934578X1400900835] [PMID: 25233607]
[114]
Wang K, Cao P, Wang H, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep 2016; 6: 26229.
[http://dx.doi.org/10.1038/srep26229] [PMID: 27189109]
[115]
Pu X, Yu S, Fan W, Liu L, Ma X, Ren J. Guiqi polysaccharide protects the normal human fetal lung fibroblast WI-38 cells from H2O2-induced premature senescence. Int J Clin Exp Pathol 2015; 8(5): 4398-407.
[PMID: 26191131]
[116]
Yang Q, Qi M, Tong R, et al. Plantago asiatica L. Seed extract improves lipid accumulation and hyperglycemia in high-fat diet-induced obese mice. Int J Mol Sci 2017; 18(7) E1393
[http://dx.doi.org/10.3390/ijms18071393] [PMID: 28665305]
[117]
Khazaei M, Karimi J, Sheikh N, et al. Effects of resveratrol on receptor for advanced glycation end products (rage) expression and oxidative stress in the liver of rats with type 2 diabetes. Phytother Res 2016; 30(1): 66-71.
[http://dx.doi.org/10.1002/ptr.5501] [PMID: 26467029]
[118]
Bird JK, Raederstorff D, Weber P, Steinert RE. Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota. Adv Nutr 2017; 8(6): 839-49.
[http://dx.doi.org/10.3945/an.117.016568] [PMID: 29141969]
[119]
Cui Y, Zhang B, Zhang R, et al. Effects of resveratrol on morphology and oxidative stress of brain tissues in aging mice. Wei Sheng Yan Jiu 2013; 42(6): 995-998, 1003.
[120]
Wang LL, Sun Y, Huang K, Zheng L. Curcumin, a potential therapeutic candidate for retinal diseases. Mol Nutr Food Res 2013; 57(9): 1557-68.
[http://dx.doi.org/10.1002/mnfr.201200718] [PMID: 23417969]
[121]
Chen G, Yang X, Yang X, et al. Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving β cell function and reducing insulin resistance in diabetic rats. BMC Complement Altern Med 2017; 17(1): 507.
[http://dx.doi.org/10.1186/s12906-017-2016-5] [PMID: 29187178]
[122]
Tian J, Tang W, Xu M, et al. Shengmai San alleviates diabetic cardiomyopathy through improvement of mitochondrial lipid metabolic disorder. Cell Physiol Biochem 2018; 50(5): 1726-39.
[http://dx.doi.org/10.1159/000494791] [PMID: 30384366]
[123]
Liu R, Chen QH, Ren JW, et al. Ginseng (Panax ginseng Meyer) oligopeptides protect against binge drinking-induced liver damage through inhibiting oxidative stress and inflammation in rats. Nutrients 2018; 10(11) E1665
[http://dx.doi.org/10.3390/nu10111665] [PMID: 30400371]
[124]
Bao L, Cai X, Wang J, Zhang Y, Sun B, Li Y. Anti-fatigue effects of small molecule oligopeptides isolated from Panax ginseng C. A. Meyer in mice. Nutrients 2016; 8(12) E807
[http://dx.doi.org/10.3390/nu8120807] [PMID: 27983571]
[125]
Kim J, Jo K, Kim CS, Kim JS. Aster koraiensis extract prevents diabetes-induced retinal vascular dysfunction in spontaneously diabetic Torii rats. BMC Complement Altern Med 2017; 17(1): 497.
[http://dx.doi.org/10.1186/s12906-017-1998-3] [PMID: 29169356]
[126]
Sohn E, Kim J, Kim CS, Kim YS, Jang DS, Kim JS. Extract of the aerial parts of Aster koraiensis reduced development of diabetic nephropathy via anti-apoptosis of podocytes in streptozotocin-induced diabetic rats. Biochem Biophys Res Commun 2010; 391(1): 733-8.
[http://dx.doi.org/10.1016/j.bbrc.2009.11.129] [PMID: 19944074]
[127]
Hao EW, Deng JG, Du ZC, et al. [Experimental study on two-way application of traditional Chinese medicines capable of promoting blood circulation and removing blood stasis with neutral property in cold and hot blood stasis syndrome I]. Zhongguo Zhongyao Zazhi 2012; 37(21): 3302-6.
[PMID: 23397734]
[128]
Qiao Y, Fan CL, Tang MK. Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury. Drug Des Devel Ther 2017; 11: 3567-77.
[http://dx.doi.org/10.2147/DDDT.S152489] [PMID: 29263652]
[129]
Fan Y, Qiao Y, Huang J, Tang M. Protective effects of panax notoginseng saponins against high glucose-induced oxidative injury in rat retinal capillary endothelial cells. Evid Based Complement Alternat Med 2016; 2016 5326382
[http://dx.doi.org/10.1155/2016/5326382] [PMID: 27019662]
[130]
Cardoso S, Correia SC, Santos RX, et al. Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. Curr Mol Med 2013; 13(4): 586-601.
[http://dx.doi.org/10.2174/1566524011313040010] [PMID: 22934852]
[131]
Lee HC, Wei YH. Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2001; 2(4): 231-44.
[http://dx.doi.org/10.1023/A:1013270512172] [PMID: 11868898]
[132]
Vlassara H, Palace MR. Glycoxidation: the menace of diabetes and aging. Mt Sinai J Med 2003; 70(4): 232-41.
[PMID: 12968196]
[133]
Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE. Diabetes and advanced glycoxidation end products. Diabetes Care 2006; 29(6): 1420-32.
[http://dx.doi.org/10.2337/dc05-2096] [PMID: 16732039]
[134]
Sun K, Hu Q, Zhou CM, et al. Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion. J Ethnopharmacol 2010; 130(2): 398-406.
[http://dx.doi.org/10.1016/j.jep.2010.05.030] [PMID: 20580803]
[135]
Yu Q, Li X, Cao X. Cardioprotective effects of phenylethanoid glycoside-rich extract from cistanche deserticola in ischemia-reperfusion-induced myocardial infarction in rats. Ann Vasc Surg 2016; 34: 234-42.
[http://dx.doi.org/10.1016/j.avsg.2016.04.002] [PMID: 27129809]
[136]
Nowotny K, Jung T, Höhn A, Weber D, Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 2015; 5(1): 194-222.
[http://dx.doi.org/10.3390/biom5010194] [PMID: 25786107]
[137]
Tian FS. The protective mechanism of clinical and animal experiment study on DaHuang in the vascular disease in diabetes mellitus Master Dissertation. 2007.

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