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Review Article

急性髓系白血病蛋白翻译后修饰串扰的研究

卷 26, 期 28, 2019

页: [5317 - 5337] 页: 21

弟呕挨: 10.2174/0929867326666190503164004

价格: $65

摘要

背景：翻译后修饰（PTM）串扰是一个年轻的研究领域。但是，现在有证据表明，不同的蛋白形式及其在生物环境中的相互作用具有非凡的特征，PTM串扰研究可以描述这些特征。除了急性髓细胞性白血病（AML）样本的基因表达和磷酸化分析外，可能还有助于发现更多关于AML蛋白质组复杂性的几种PTM的功能组合。 目的：通过审查当前同时工作的多个PTM和生物信息学工具的富集工作流，以分析基于质谱（MS）的数据，我们的主要目标是向AML研究社区介绍PTM串扰领域。 结果：在介绍了PTM和PTM串扰之后，本文将介绍几种同时富集PTM的协议。当使用0.5-2 mg细胞溶解产物时，其中两个可以同时富集至少三个PTM。我们已经审查了许多用于PTM串扰发现的生物信息学工具，因为其复杂的数据分析（主要来自MS）对于大多数AML研究人员而言都具有挑战性。在整个综述中，我们提出了一些非AML PTM串扰研究，以显示PTM串扰的表征对于选择疾病生物标志物和治疗靶标的重要性。 结论：在本文中，我们回顾了新兴的PTM串扰领域的进展和陷阱及其对揭示AML异质性的潜在贡献。样品制备和生物信息学工作流程的复杂性要求多个领域的专家之间进行良好的互动。

关键词: 急性髓细胞性白血病，翻译后修饰，串扰，蛋白质组，磷酸化蛋白质组，乙酰基蛋白质组， 甲基蛋白质组，糖蛋白组，泛素组，质谱，生物标志物，蛋白形式。

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