Title:Demographic and Clinical Evaluation of Patients with Pancreatic Cancer in Mashhad University of Medical Sciences During 2002-2013
Volume: 16
Issue: 2
Author(s): Mina A. Rad, Azar Fanipakdel, Hassan Vossoughinia, Maliheh Dadgarmoghaddam, Benyamin Esmaeili, Amir H. Jafarian, Masoumeh Salari*Abdollah Firoozi
Affiliation:
- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Pancreatic cancer, demographics characteristics, clinical characteristics, gastric cancer, smoking, opium, alcohol.
Abstract:
Introduction: Pancreatic cancer consists of 10% of digestive tract tumors, and while
rare, it is associated with high mortality. In this study, we collected the patients’ data including
tumor location, metastasis, pathology type, demographic factors, risk factors, and clinical and
laboratory profile at the time of diagnosis to find the relation between these factors and disease
progression.
Methods: This study includes all data from real charts of patients with a definitive diagnosis of
pancreatic cancer, admitted to Ghaem, Imam Reza, and Omid hospitals from 2002 to 2013. All
the data which were available in lab results, exams, and patient files, were used accordingly.
Results: 348 pancreatic cancer patients entered the study. About 61.5% of the subjects were men.
Mean age was 59.67±14.37 years. Main complaints were abdominal pain (42.53%), jaundice
(13.79%) or both (37.07%). We found a positive history of cancer in the first-degree relatives of
3.7% of patients, with the most prevalent being gastric cancer (46.1%). Cigarette smoking
(P<0.001), tobacco smoking (cigarette or hookah) (P<0.001), opium use (P<0.001), and alcohol
consumption (P=0.01) were significantly higher in men rather than women. However, hookah
smoking was significantly higher in women (P=0.003). The most prevalent comorbidities were
diabetes mellitus (33%) and hypertension (27.8%). The most common location of pancreatic
cancer was head of the pancreas (85.3%). The most common pancreatic tumor pathology was
adenocarcinoma (92.8%) with the same quiet prevalence in both genders. (P=0.5), It occurred significantly
more in patients over 45 years old (P<0.001). Also, 45.7% of these patients had distant
metastasis and liver was the most common metastatic site (69.8%).
Conclusion: The age range was between 40 and 80 years old. The most common chief complaints
were jaundice and abdominal pain. The most common tumor location was head of the pancreas.
Adenocarcinoma was the most common pathology. The liver was the most common metastasis
site.
