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Review Article

系统性红斑狼疮危险因素的化学和药物的机制的见解

卷 27, 期 31, 2020

页: [5175 - 5188] 页: 14

弟呕挨: 10.2174/0929867326666190404140658

价格: $65

摘要

系统性红斑狼疮(SLE)是一种慢性和复发的异质性自身免疫性疾病，主要影响育龄妇女。遗传和环境危险因素参与红斑狼疮的发病机制，易感基因最近已被确定。然而，由于基因治疗离临床应用还很遥远，对环境危险因素的进一步研究可以揭示重要的治疗方法。我们系统地探索了两组环境风险因素:化学物质(包括二氧化硅、溶剂、杀虫剂、碳氢化合物、重金属和颗粒物)和药物(包括普鲁卡因胺、肼嗪、奎尼丁、青霉胺、异烟肼和甲基多巴)。此外，还探讨了潜在风险因素的机制，如遗传因素、表观遗传变化和免疫耐受中断。这篇综述确定了新的危险因素及其潜在的机制。管理这些危险因素的可行措施将有益于SLE患者，并提供潜在的治疗策略。

关键词: 危险因素，系统性红斑狼疮，自身免疫，遗传因素，表观遗传变化，免疫耐受

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