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当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

阿尔茨海默病在黑暗中的异常骶管入侵

卷 16, 期 4, 2019

页: [293 - 301] 页: 9

弟呕挨: 10.2174/1567205016666190311102130

价格: $65

摘要

背景:分类为扫视入侵,在阿尔茨海默病(AD)的视觉固定(VF)期间观察到Square-Wave Jerks(SWJs)。然而,这种现象的病理意义仍不清楚。 目的:本研究分析了AD患者在没有VF的情况下睁眼的SWJs的特征。 方法:对15名AD患者和15名健康的年龄和性别匹配对照进行调查和比较。使用和不使用VF的Saccadic侵入被检测为SWJ并使用电子眼震图测量。 结果:对照组和AD组VF之间SWJs频率无显着差异,但在没有VF的情况下,AD组中SWJs显着高于对照组(p <0.01)。在对照组中,与没有VF相比,VF的SWJ频率显着更高。相反,没有VF,AD组的频率显着更高。此外,在AD组的SWJ频率和高阶函数(R> 0.55)之间观察到直接比例关系。 结论:无ADF的SWJs可能在AD中具有病理学意义。在健康个体中,SWJ由VF产生并且在没有VF的情况下被抑制。相反,在AD中,在没有VF的情况下产生SWJ而不是抑制SWJ。这些没有VF的特异性SWJ也似乎与高阶功能障碍相关,反映了AD相关的皮质损伤。这些发现表明,在AD中观察到的没有VF的病理性SWJs来自皮质损伤,并且可能构成高阶功能的重要标志物。

关键词: 阿尔茨海默病,眼球运动,眼跳入侵,方波混蛋,视觉固定,高阶功能,下顶叶小叶,额叶眼。

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