Title: Crystal Structures of Acridines Complexed with Nucleic Acids
Volume: 9
Issue: 18
Author(s): Adrienne Adams
Affiliation:
Keywords:
acridines, crystal structures, nucleic acids, DNA, complexes, acridine-4-carboxamides
Abstract: Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.
