Title:Comprehensive Review on Graphene Oxide for Use in Drug Delivery System
Volume: 27
Issue: 22
Author(s): Muhammad Daniyal, Bin Liu and Wei Wang*
Affiliation:
- TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208,China
Keywords:
Graphene, graphene oxide, nano-medicine, drug delivery system, graphene DDS, highly oriented pyrolytic
graphite (HOPG).
Abstract: Motivated by the accomplishment of carbon nanotubes (CNTs), graphene and graphene
oxide (GO) has been widely investigated in the previous studies as an innovative medication
nanocarrier for the loading of a variety of therapeutics as well as anti-cancer medications, poor
dissolvable medications, antibiotics, antibodies, peptides, DNA, RNA and genes. Graphene provides
the ultra-high drug-loading efficiency due to the wide surface area. Graphene and graphene oxide
have been widely investigated for biomedical applications due to their exceptional qualities: twodimensional
planar structure, wide surface area, chemical and mechanical constancy, sublime
conductivity and excellent biocompatibility. Due to these unique qualities, GO applications provide
advanced drug transports frameworks and transports of a broad range of therapeutics. In this review,
we discussed the latest advances and improvements in the uses of graphene and GO for drug
transport and nanomedicine. Initially, we have described what is graphene and graphene oxide.
After that, we discussed the qualities of GO as a drug carrier, utilization of GO in drug transport
applications, targeted drug transport, transport of anticancer medications, chemical control medicine
releasee, co-transport of different medications, comparison of GO with CNTs, nano-graphene for
drug transport and at last, we have discussed the graphene toxicity. Finally, we draw a conclusion of
current expansion and the potential outlook for the future.