Title:Oxidative Stress and Accelerated Aging in Neurodegenerative and Neuropsychiatric Disorder
Volume: 24
Issue: 40
Author(s): Ridhima Wadhwa, Riya Gupta and Pawan K. Maurya*
Affiliation:
- Department of Biochemistry, Central University of Haryana, Jant-Pali, Mahendergarh District-123031, Haryana,India
Keywords:
Oxidative Stress, neurodegenerative diseases, Alzeimer, Parkinsons disease, schizophrenia, bipolar, depression.
Abstract: Background: Neurodegenerative diseases are becoming more and more common in today’s world. As
people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays,
environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though
some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in
organisms causes neurodegenerative diseases. These neurodegenerative disorders like Alzeimers, Parkinsons
disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in
physiological and psychological functions caused by ROS and RNS. These ROS and RNS are formed as the
result of excess oxidative damage in the system.
Methods: The following article goes into detail explaining all the effects caused by excess oxidative damage like
ROS/RNS formation and telomere shortening. Further, it explains the pathways of neurodegenerative diseases
and neuropsychiatric diseases. This article also sheds light on the effective treatments of such disorders by changing
lifestyle and activating antioxidant pathways.
Conclusion: It is clear that neurodegenerative diseases are caused due to excess oxidative stress and alter the
functioning of the central nervous system. The central nervous system undergoes neurodegenerative or
neuropsychiatric changes.
