Title:Oxidative Stress and Kidney Function: A Brief Update
Volume: 24
Issue: 40
Author(s): Giuseppe Coppolino*, Giuseppe Leonardi, Michele Andreucci and Davide Bolignano
Affiliation:
- Department of Health Sciences, Magna Graecia University, Catanzaro,Italy
Keywords:
Oxidative stress, renal function, chronic Kidney Disease (CKD), reactive oxygen species (ROS), cellular senescence, carbohydrates.
Abstract: In this review we summarized some information regarding the link between kidney and oxidative
stress. Accruing evidences indicated the kidney as a fundamental organ in reactive oxygen species (ROS) production.
ROS are highly reactive and cause in single cells: protein alteration, DNA damage, cellular senescence and
apoptosis; while the effect of ROS in biological tissues leads to a harmful oxidation effect on all their biochemical
components: lipids, proteins, carbohydrates, and nucleic acids. Oxidative stress plays a role in the pathophysiology
of renal impairment and is a mediator of CKD progression; furthermore, during substitutive therapy with
haemodialysis or peritoneal dialysis and in case of transplantation, organism continues to be exposed to oxidation
causing the development of major systemic comorbidities in particular cardiovascular diseases.
