Title:Nanomedicine for Cancer Therapy Using Autophagy: An Overview
Volume: 18
Issue: 30
Author(s): Rajesh Kotcherlakota, Syed Tazib Rahaman and Chitta Ranjan Patra*
Affiliation:
- Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002,India
Keywords:
Cancer, Nanomedicine, Autophagy, Eukaryotic cell, Lysosome, Drug delivery.
Abstract: Autophagy is an intracellular biological catabolic process of mammalian cells to maintain the
homeostasis. It plays a wide role in the clearance of damaged cellular organelles, misfolded or aggregated
proteins like alpha-synuclein, β-amyloid peptides, Tau proteins and pathogens. Recent studies
have clearly demonstrated that dysfunction in autophagy leads to the development of cancer, cardiomyopathy,
chronic infection, neurodegenerative and other diseases. Therefore, modulation of autophagy
has therapeutic value to cure the diseases including cancer using external stimuli. In this context, various
researchers developed small molecules such as chloroquine, rapamycin, etc. for the treatment of cancer
through autophagy. However, these molecules possess side effects which limit their use in the clinics.
Therefore, nanomedicine approach could stand as an alternative treatment option to induce the autophagy
in cancer therapy. Several investigators developed a variety of nanomaterials which themselves
act as autophagy inducers or inhibitors. Considering this, the present review article will focus on the recent
developments of nanomedicine in the area of autophagy that have been focused on the treatment of
cancers. We also summarised the detailed mechanisms of nanoparticles mediated autophagy which
could be helpful for developing new strategies to fight against cancer. Also, the present review article
covers the current clinical status of nanomedicine and future challenges. Finally, we conclude with the
future potential role of nanomedicine for autophagy induction in the cancer treatment.
