Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research

Harel, D.; Carmel, L.; Lancet, D. Towards an odor communication system. Comput. Biol. Chem., 2003, 27(2), 121-133.
[http://dx.doi.org/10.1016/S1476-9271(02)00092-0] [PMID: 12821309]

Breer, H. Olfactory receptors: molecular basis for recognition and discrimination of odors. Anal. Bioanal. Chem., 2003, 377(3), 427-433.
[http://dx.doi.org/10.1007/s00216-003-2113-9] [PMID: 12898108]

Spehr, M.; Munger, S.D. Olfactory receptors: G protein-coupled receptors and beyond. J. Neurochem., 2009, 109(6), 1570-1583.
[http://dx.doi.org/10.1111/j.1471-4159.2009.06085.x] [PMID: 19383089]

Touhara, K.; Vosshall, L.B. Sensing odorants and pheromones with chemosensory receptors. Annu. Rev. Physiol., 2009, 71, 307-332.
[http://dx.doi.org/10.1146/annurev.physiol.010908.163209] [PMID: 19575682]

Sarafoleanu, C.; Mella, C.; Georgescu, M.; Perederco, C. The importance of the olfactory sense in the human behavior and evolution. J. Med. Life, 2009, 2(2), 196-198.
[PMID: 20108540]

Bear, D.M.; Lassance, J.M.; Hoekstra, H.E.; Datta, S.R. Evolution of the genetic and neural architecture for vertebrate odor perception. Curr. Biol., 2016, 26, R1039-R1049.
[http://dx.doi.org/10. 1016/j.cub.2016.09.011] [PMID: 27780046]

Buck, L.; Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 1991, 65(1), 175-187.
[http://dx.doi.org/10.1016/0092-8674(91)90418-X] [PMID: 1840504]

Zhang, X.; Firestein, S. The olfactory receptor gene superfamily of the mouse. Nat. Neurosci., 2002, 5(2), 124-133.
[http://dx.doi.org/ 10.1038/nn800] [PMID: 11802173]

Lander, E.S.; Linton, L.M.; Birren, B.; Nusbaum, C.; Zody, M.C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; FitzHugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; LeVine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J.P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; Sougnez, C.; Stange-Thomann, Y.; Stojanovic, N.; Subramanian, A.; Wyman, D.; Rogers, J.; Sulston, J.; Ainscough, R.; Beck, S.; Bentley, D.; Burton, J.; Clee, C.; Carter, N.; Coulson, A.; Deadman, R.; Deloukas, P.; Dunham, A.; Dunham, I.; Durbin, R.; French, L.; Grafham, D.; Gregory, S.; Hubbard, T.; Humphray, S.; Hunt, A.; Jones, M.; Lloyd, C.; McMurray, A.; Matthews, L.; Mercer, S.; Milne, S.; Mullikin, J.C.; Mungall, A.; Plumb, R.; Ross, M.; Shownkeen, R.; Sims, S.; Waterston, R.H.; Wilson, R.K.; Hillier, L.W.; McPherson, J.D.; Marra, M.A.; Mardis, E.R.; Fulton, L.A.; Chinwalla, A.T.; Pepin, K.H.; Gish, W.R.; Chissoe, S.L.; Wendl, M.C.; Delehaunty, K.D.; Miner, T.L.; Delehaunty, A.; Kramer, J.B.; Cook, L.L.; Fulton, R.S.; Johnson, D.L.; Minx, P.J.; Clifton, S.W.; Hawkins, T.; Branscomb, E.; Predki, P.; Richardson, P.; Wenning, S.; Slezak, T.; Doggett, N.; Cheng, J.F.; Olsen, A.; Lucas, S.; Elkin, C.; Uberbacher, E.; Frazier, M.; Gibbs, R.A.; Muzny, D.M.; Scherer, S.E.; Bouck, J.B.; Sodergren, E.J.; Worley, K.C.; Rives, C.M.; Gorrell, J.H.; Metzker, M.L.; Naylor, S.L.; Kucherlapati, R.S.; Nelson, D.L.; Weinstock, G.M.; Sakaki, Y.; Fujiyama, A.; Hattori, M.; Yada, T.; Toyoda, A.; Itoh, T.; Kawagoe, C.; Watanabe, H.; Totoki, Y.; Taylor, T.; Weissenbach, J.; Heilig, R.; Saurin, W.; Artiguenave, F.; Brottier, P.; Bruls, T.; Pelletier, E.; Robert, C.; Wincker, P.; Smith, D.R.; Doucette-Stamm, L.; Rubenfield, M.; Weinstock, K.; Lee, H.M.; Dubois, J.; Rosenthal, A.; Platzer, M.; Nyakatura, G.; Taudien, S.; Rump, A.; Yang, H.; Yu, J.; Wang, J.; Huang, G.; Gu, J.; Hood, L.; Rowen, L.; Madan, A.; Qin, S.; Davis, R.W.; Federspiel, N.A.; Abola, A.P.; Proctor, M.J.; Myers, R.M.; Schmutz, J.; Dickson, M.; Grimwood, J.; Cox, D.R.; Olson, M.V.; Kaul, R.; Raymond, C.; Shimizu, N.; Kawasaki, K.; Minoshima, S.; Evans, G.A.; Athanasiou, M.; Schultz, R.; Roe, B.A.; Chen, F.; Pan, H.; Ramser, J.; Lehrach, H.; Reinhardt, R.; McCombie, W.R.; de la Bastide, M.; Dedhia, N.; Blöcker, H.; Hornischer, K.; Nordsiek, G.; Agarwala, R.; Aravind, L.; Bailey, J.A.; Bateman, A.; Batzoglou, S.; Birney, E.; Bork, P.; Brown, D.G.; Burge, C.B.; Cerutti, L.; Chen, H.C.; Church, D.; Clamp, M.; Copley, R.R.; Doerks, T.; Eddy, S.R.; Eichler, E.E.; Furey, T.S.; Galagan, J.; Gilbert, J.G.; Harmon, C.; Hayashizaki, Y.; Haussler, D.; Hermjakob, H.; Hokamp, K.; Jang, W.; Johnson, L.S.; Jones, T.A.; Kasif, S.; Kaspryzk, A.; Kennedy, S.; Kent, W.J.; Kitts, P.; Koonin, E.V.; Korf, I.; Kulp, D.; Lancet, D.; Lowe, T.M.; McLysaght, A.; Mikkelsen, T.; Moran, J.V.; Mulder, N.; Pollara, V.J.; Ponting, C.P.; Schuler, G.; Schultz, J.; Slater, G.; Smit, A.F.; Stupka, E.; Szustakowki, J.; Thierry-Mieg, D.; Thierry-Mieg, J.; Wagner, L.; Wallis, J.; Wheeler, R.; Williams, A.; Wolf, Y.I.; Wolfe, K.H.; Yang, S.P.; Yeh, R.F.; Collins, F.; Guyer, M.S.; Peterson, J.; Felsenfeld, A.; Wetterstrand, K.A.; Patrinos, A.; Morgan, M.J.; de Jong, P.; Catanese, J.J.; Osoegawa, K.; Shizuya, H.; Choi, S.; Chen, Y.J.; Szustakowki, J. Initial sequencing and analysis of the human genome. Nature, 2001, 409(6822), 860-921.
[http://dx.doi.org/10.1038/35057062] [PMID: 11237011]

Venter, J.C.; Adams, M.D.; Myers, E.W.; Li, P.W.; Mural, R.J.; Sutton, G.G.; Smith, H.O.; Yandell, M.; Evans, C.A.; Holt, R.A.; Gocayne, J.D.; Amanatides, P.; Ballew, R.M.; Huson, D.H.; Wortman, J.R.; Zhang, Q.; Kodira, C.D.; Zheng, X.H.; Chen, L.; Skupski, M.; Subramanian, G.; Thomas, P.D.; Zhang, J.; Gabor Miklos, G.L.; Nelson, C.; Broder, S.; Clark, A.G.; Nadeau, J.; McKusick, V.A.; Zinder, N.; Levine, A.J.; Roberts, R.J.; Simon, M.; Slayman, C.; Hunkapiller, M.; Bolanos, R.; Delcher, A.; Dew, I.; Fasulo, D.; Flanigan, M.; Florea, L.; Halpern, A.; Hannenhalli, S.; Kravitz, S.; Levy, S.; Mobarry, C.; Reinert, K.; Remington, K.; Abu-Threideh, J.; Beasley, E.; Biddick, K.; Bonazzi, V.; Brandon, R.; Cargill, M.; Chandramouliswaran, I.; Charlab, R.; Chaturvedi, K.; Deng, Z.; Di Francesco, V.; Dunn, P.; Eilbeck, K.; Evangelista, C.; Gabrielian, A.E.; Gan, W.; Ge, W.; Gong, F.; Gu, Z.; Guan, P.; Heiman, T.J.; Higgins, M.E.; Ji, R.R.; Ke, Z.; Ketchum, K.A.; Lai, Z.; Lei, Y.; Li, Z.; Li, J.; Liang, Y.; Lin, X.; Lu, F.; Merkulov, G.V.; Milshina, N.; Moore, H.M.; Naik, A.K.; Narayan, V.A.; Neelam, B.; Nusskern, D.; Rusch, D.B.; Salzberg, S.; Shao, W.; Shue, B.; Sun, J.; Wang, Z.; Wang, A.; Wang, X.; Wang, J.; Wei, M.; Wides, R.; Xiao, C.; Yan, C.; Yao, A.; Ye, J.; Zhan, M.; Zhang, W.; Zhang, H.; Zhao, Q.; Zheng, L.; Zhong, F.; Zhong, W.; Zhu, S.; Zhao, S.; Gilbert, D.; Baumhueter, S.; Spier, G.; Carter, C.; Cravchik, A.; Woodage, T.; Ali, F.; An, H.; Awe, A.; Baldwin, D.; Baden, H.; Barnstead, M.; Barrow, I.; Beeson, K.; Busam, D.; Carver, A.; Center, A.; Cheng, M.L.; Curry, L.; Danaher, S.; Davenport, L.; Desilets, R.; Dietz, S.; Dodson, K.; Doup, L.; Ferriera, S.; Garg, N.; Gluecksmann, A.; Hart, B.; Haynes, J.; Haynes, C.; Heiner, C.; Hladun, S.; Hostin, D.; Houck, J.; Howland, T.; Ibegwam, C.; Johnson, J.; Kalush, F.; Kline, L.; Koduru, S.; Love, A.; Mann, F.; May, D.; McCawley, S.; McIntosh, T.; McMullen, I.; Moy, M.; Moy, L.; Murphy, B.; Nelson, K.; Pfannkoch, C.; Pratts, E.; Puri, V.; Qureshi, H.; Reardon, M.; Rodriguez, R.; Rogers, Y.H.; Romblad, D.; Ruhfel, B.; Scott, R.; Sitter, C.; Smallwood, M.; Stewart, E.; Strong, R.; Suh, E.; Thomas, R.; Tint, N.N.; Tse, S.; Vech, C.; Wang, G.; Wetter, J.; Williams, S.; Williams, M.; Windsor, S.; Winn-Deen, E.; Wolfe, K.; Zaveri, J.; Zaveri, K.; Abril, J.F.; Guigó, R.; Campbell, M.J.; Sjolander, K.V.; Karlak, B.; Kejariwal, A.; Mi, H.; Lazareva, B.; Hatton, T.; Narechania, A.; Diemer, K.; Muruganujan, A.; Guo, N.; Sato, S.; Bafna, V.; Istrail, S.; Lippert, R.; Schwartz, R.; Walenz, B.; Yooseph, S.; Allen, D.; Basu, A.; Baxendale, J.; Blick, L.; Caminha, M.; Carnes-Stine, J.; Caulk, P.; Chiang, Y.H.; Coyne, M.; Dahlke, C.; Mays, A.; Dombroski, M.; Donnelly, M.; Ely, D.; Esparham, S.; Fosler, C.; Gire, H.; Glanowski, S.; Glasser, K.; Glodek, A.; Gorokhov, M.; Graham, K.; Gropman, B.; Harris, M.; Heil, J.; Henderson, S.; Hoover, J.; Jennings, D.; Jordan, C.; Jordan, J.; Kasha, J.; Kagan, L.; Kraft, C.; Levitsky, A.; Lewis, M.; Liu, X.; Lopez, J.; Ma, D.; Majoros, W.; McDaniel, J.; Murphy, S.; Newman, M.; Nguyen, T.; Nguyen, N.; Nodell, M.; Pan, S.; Peck, J.; Peterson, M.; Rowe, W.; Sanders, R.; Scott, J.; Simpson, M.; Smith, T.; Sprague, A.; Stockwell, T.; Turner, R.; Venter, E.; Wang, M.; Wen, M.; Wu, D.; Wu, M.; Xia, A.; Zandieh, A.; Zhu, X. The sequence of the human genome. Science, 2001, 291(5507), 1304-1351.
[http://dx.doi.org/10.1126/science.1058040] [PMID: 11181995]

Glusman, G.; Yanai, I.; Rubin, I.; Lancet, D. The complete human olfactory subgenome. Genome Res., 2001, 11(5), 685-702.
[http://dx.doi.org/10.1101/gr.171001] [PMID: 11337468]

Niimura, Y.; Nei, M. Comparative evolutionary analysis of olfactory receptor gene clusters between humans and mice. Gene, 2005, 346, 13-21.
[http://dx.doi.org/10.1016/j.gene.2004.09.025] [PMID: 15716120]

Zozulya, S.; Echeverri, F.; Nguyen, T. The human olfactory receptor repertoire Genome Biol, 2001, 2(6), 18.1-18.12,

Malnic, B.; Godfrey, P.A.; Buck, L.B. The human olfactory receptor gene family. Proc. Natl. Acad. Sci. USA, 2004, 101(8), 2584-2589.
[http://dx.doi.org/10.1073/pnas.0307882100] [PMID: 14983052]

Godfrey, P.A.; Malnic, B.; Buck, L.B. The mouse olfactory receptor gene family. Proc. Natl. Acad. Sci. USA, 2004, 101(7), 2156-2161.
[http://dx.doi.org/10.1073/pnas.0308051100] [PMID: 14769939]

Breer, H.; Fleischer, J.; Strotmann, J. The sense of smell: multiple olfactory subsystems. Cell. Mol. Life Sci., 2006, 63(13), 1465-1475.
[http://dx.doi.org/10.1007/s00018-006-6108-5] [PMID: 16732429]

Strotmann, J.; Levai, O.; Fleischer, J.; Schwarzenbacher, K.; Breer, H. Olfactory receptor proteins in axonal processes of chemosensory neurons. J. Neurosci., 2004, 24(35), 7754-7761.
[http://dx.doi.org/ 10.1523/JNEUROSCI.2588-04.2004] [PMID: 15342743]

Menco, B.P.; Bruch, R.C.; Dau, B.; Danho, W. Ultrastructural localization of olfactory transduction components: the G protein subunit Golf alpha and type III adenylyl cyclase. Neuron, 1992, 8(3), 441-453.
[http://dx.doi.org/10.1016/0896-6273(92)90272-F] [PMID: 1550671]

Mombaerts, P. How smell develops. Nat. Neurosci., 2001, 4(Suppl.), 1192-1198.
[http://dx.doi.org/10.1038/nn751] [PMID: 11687829]

Lodovichi, C.; Belluscio, L. Odorant receptors in the formation of the olfactory bulb circuitry. Physiology (Bethesda), 2012, 27(4), 200-212.
[http://dx.doi.org/10.1152/physiol.00015.2012] [PMID: 22875451]

Witt, M.; Woźniak, W. Structure and function of the vomeronasal organ. Adv. Otorhinolaryngol., 2006, 63, 70-83.
[http://dx.doi.org/ 10.1159/000093751] [PMID: 16733333]

Meredith, M. Human vomeronasal organ function: a critical review of best and worst cases. Chem. Senses, 2001, 26(4), 433-445.
[http://dx.doi.org/10.1093/chemse/26.4.433] [PMID: 11369678]

Dulac, C.; Axel, R. A novel family of genes encoding putative pheromone receptors in mammals. Cell, 1995, 83(2), 195-206.
[http://dx.doi.org/10.1016/0092-8674(95)90161-2] [PMID: 7585937]

Rodriguez, I.; Mombaerts, P. Novel human vomeronasal receptor-like genes reveal species-specific families. Curr. Biol., 2002, 12(12), R409-R411.
[http://dx.doi.org/10.1016/S0960-9822(02) 00909-0] [PMID: 12123587]

Rodriguez, I.; Feinstein, P.; Mombaerts, P. Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell, 1999, 97(2), 199-208.
[http://dx.doi.org/10.1016/S0092-8674(00)80730-8] [PMID: 10219241]

Roppolo, D.; Vollery, S.; Kan, C.D.; Lüscher, C.; Broillet, M.C.; Rodriguez, I. Gene cluster lock after pheromone receptor gene choice. EMBO J., 2007, 26(14), 3423-3430.
[http://dx.doi.org/10. 1038/sj.emboj.7601782] [PMID: 17611603]

Mombaerts, P. Odorant receptor gene choice in olfactory sensory neurons: the one receptor-one neuron hypothesis revisited. Curr. Opin. Neurobiol., 2004, 14(1), 31-36 b.
[http://dx.doi.org/10.1016/j.conb.2004.01.014] [PMID: 15018935]

Dulac, C.; Wagner, S. Genetic analysis of brain circuits underlying pheromone signaling. Annu. Rev. Genet., 2006, 40, 449-467.
[http://dx.doi.org/10.1146/annurev.genet.39.073003.093937] [PMID: 16953793]

Shi, P.; Zhang, J. Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res., 2007, 17(2), 166-174.
[http://dx.doi.org/10.1101/gr.6040007] [PMID: 17210926]

Grus, W.E.; Shi, P.; Zhang, Y.P.; Zhang, J. Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals. Proc. Natl. Acad. Sci. USA, 2005, 102(16), 5767-5772.
[http://dx.doi.org/10.1073/pnas. 0501589102] [PMID: 15790682]

Herrada, G.; Dulac, C. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell, 1997, 90(4), 763-773.
[http://dx.doi.org/10.1016/S0092-8674(00)80536-X] [PMID: 9288755]

Matsunami, H.; Buck, L.B. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell, 1997, 90(4), 775-784.
[http://dx.doi.org/10.1016/S0092-8674(00)80537-1] [PMID: 9288756]

Ryba, N.J.; Tirindelli, R. A new multigene family of putative pheromone receptors. Neuron, 1997, 19(2), 371-379.
[http://dx.doi.org/10.1016/S0896-6273(00)80946-0] [PMID: 9292726]

Young, J.M.; Trask, B.J. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Trends Genet., 2007, 23(5), 212-215.
[http://dx.doi.org/10.1016/j.tig.2007.03.004] [PMID: 17382427]

Silvotti, L.; Moiani, A.; Gatti, R.; Tirindelli, R. Combinatorial co-expression of pheromone receptors, V2Rs. J. Neurochem., 2007, 103(5), 1753-1763.
[http://dx.doi.org/10.1111/j.1471-4159.2007. 04877.x] [PMID: 17854397]

Rodriguez, I.; Greer, C.A.; Mok, M.Y.; Mombaerts, P. A putative pheromone receptor gene expressed in human olfactory mucosa. Nat. Genet., 2000, 26(1), 18-19.
[http://dx.doi.org/10.1038/79124] [PMID: 10973240]

Savic, I.; Berglund, H.; Gulyas, B.; Roland, P. Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron, 2001, 31(4), 661-668.
[http://dx.doi.org/10.1016/S0896-6273(01)00390-7] [PMID: 11545724]

Kosaka, T.; Kosaka, K. Olfactory Anatomy. Reference Module in Biomedical Research. Elsevier

Mombaerts, P. Seven-transmembrane proteins as odorant and chemosensory receptors. Science, 1999, 286(5440), 707-711.
[http://dx.doi.org/10.1126/science.286.5440.707] [PMID: 10531047]

Mombaerts, P. Molecular biology of odorant receptors in vertebrates. Annu. Rev. Neurosci., 1999, 22, 487-509.
[http://dx.doi.org/ 10.1146/annurev.neuro.22.1.487] [PMID: 10202546]

Pilpel, Y.; Sosinsky, A.; Lancet, D. Molecular biology of olfactory receptors. Essays Biochem., 1998, 33, 93-104.
[http://dx.doi.org/ 10.1042/bse0330093] [PMID: 10488444]

Rouquier, S.; Taviaux, S.; Trask, B.J.; Brand-Arpon, V.; van den Engh, G.; Demaille, J.; Giorgi, D. Distribution of olfactory receptor genes in the human genome. Nat. Genet., 1998, 18(3), 243-250.
[http://dx.doi.org/10.1038/ng0398-243] [PMID: 9500546]

Rouquier, S.; Blancher, A.; Giorgi, D. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. Proc. Natl. Acad. Sci. USA, 2000, 97(6), 2870-2874.
[http://dx.doi.org/10.1073/pnas.040580197] [PMID: 10706615]

Serizawa, S.; Miyamichi, K.; Nakatani, H.; Suzuki, M.; Saito, M.; Yoshihara, Y.; Sakano, H. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science, 2003, 302(5653), 2088-2094.
[http://dx.doi.org/10.1126/science.1089122] [PMID: 14593185]

Lewcock, J.W.; Reed, R.R. A feedback mechanism regulates monoallelic odorant receptor expression. Proc. Natl. Acad. Sci. USA, 2004, 101(4), 1069-1074.
[http://dx.doi.org/10.1073/pnas. 0307986100] [PMID: 14732684]

senselab.med.yale.edu/ordb (Accessed June 25, 2018)

Glusman, G.; Clifton, S.; Roe, B.; Lancet, D. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. Genomics, 1996, 37(2), 147-160.
[http://dx.doi.org/10.1006/geno.1996.0536] [PMID: 8921386]

Walensky, L.D.; Ruat, M.; Bakin, R.E.; Blackshaw, S.; Ronnett, G.V.; Snyder, S.H. Two novel odorant receptor families expressed in spermatids undergo 5′-splicing. J. Biol. Chem., 1998, 273(16), 9378-9387.
[http://dx.doi.org/10.1074/jbc.273.16.9378] [PMID: 9545261]

Asai, H.; Kasai, H.; Matsuda, Y.; Yamazaki, N.; Nagawa, F.; Sakano, H.; Tsuboi, A. Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells. Biochem. Biophys. Res. Commun., 1996, 221(2), 240-247.
[http://dx.doi.org/10.1006/bbrc.1996.0580] [PMID: 8619840]

Qasba, P.; Reed, R.R. Tissue and zonal-specific expression of an olfactory receptor transgene. J. Neurosci., 1998, 18(1), 227-236.
[http://dx.doi.org/10.1523/JNEUROSCI.18-01-00227.1998] [PMID: 9412503]

Safran, M.; Chalifa-Caspi, V.; Shmueli, O.; Olender, T.; Lapidot, M.; Rosen, N.; Shmoish, M.; Peter, Y.; Glusman, G.; Feldmesser, E.; Adato, A.; Peter, I.; Khen, M.; Atarot, T.; Groner, Y.; Lancet, D. Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE. Nucleic Acids Res., 2003, 31(1), 142-146.
[http://dx.doi.org/10.1093/nar/gkg050] [PMID: 12519968]

Olender, T.; Feldmesser, E.; Atarot, T.; Eisenstein, M.; Lancet, D. The olfactory receptor universe--from whole genome analysis to structure and evolution. Genet. Mol. Res., 2004, 3(4), 545-553.
[PMID: 15688320]

Olender, T.; Lancet, D.; Nebert, D.W. Update on the olfactory receptor (OR) gene superfamily. Hum. Genomics, 2008, 3(1), 87-97.
[http://dx.doi.org/10.1186/1479-7364-3-1-87] [PMID: 19129093]

Nebert, D.W.; Adesnik, M.; Coon, M.J.; Estabrook, R.W.; Gonzalez, F.J.; Guengerich, F.P.; Gunsalus, I.C.; Johnson, E.F.; Kemper, B.; Levin, W. The P450 gene superfamily. Recommended nomenclature. DNA Cell Biol., 1987, 6, 1-11.
[PMID: 1991046]

Nebert, D.W.; Gonzalez, F.J. P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem., 1987, 56, 945-993.
[http://dx.doi.org/10.1146/annurev.bi.56.070187.004501] [PMID: 3304150]

Nebert, D.W.; Nelson, D.R.; Adesnik, M.; Coon, M.J.; Estabrook, R.W.; Gonzalez, F.J.; Guengerich, F.P.; Gunsalus, I.C.; Johnson, E.F.; Kemper, B. The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA, 1989, 8(1), 1-13.
[http://dx.doi.org/10.1089/dna.1.1989.8.1] [PMID: 2651058]

Nebert, D.W.; Nelson, D.R.; Coon, M.J.; Estabrook, R.W.; Feyereisen, R.; Fujii-Kuriyama, Y.; Gonzalez, F.J.; Guengerich, F.P.; Gunsalus, I.C.; Johnson, E.F. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol., 1991, 10(1), 1-14.
[http://dx.doi.org/10.1089/dna. 1991.10.1] [PMID: 1991046]

Nelson, D.R.; Kamataki, T.; Waxman, D.J.; Guengerich, F.P.; Estabrook, R.W.; Feyereisen, R.; Gonzalez, F.J.; Coon, M.J.; Gunsalus, I.C.; Gotoh, O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol., 1993, 12(1), 1-51.
[http://dx.doi.org/10.1089/dna.1993.12.1] [PMID: 7678494]

Nelson, D.R.; Koymans, L.; Kamataki, T.; Stegeman, J.J.; Feyereisen, R.; Waxman, D.J.; Waterman, M.R.; Gotoh, O.; Coon, M.J.; Estabrook, R.W.; Gunsalus, I.C.; Nebert, D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 1996, 6(1), 1-42.
[http://dx.doi.org/10.1097/00008571-199602000-00002] [PMID: 8845856]

Glusman, G.; Bahar, A.; Sharon, D.; Pilpel, Y.; White, J.; Lancet, D. The olfactory receptor gene superfamily: data mining, classification, and nomenclature. Mamm. Genome, 2000, 11(11), 1016-1023.
[http://dx.doi.org/10.1007/s003350010196] [PMID: 11063259]

Lancet. D.; Ben-Arie, N. Olfactory receptors. Curr. Biol., 1993, 3(10), 668-674.
[http://dx.doi.org/10.1016/0960-9822(93)90064-U] [PMID: 15335857]

Mombaerts, P. Genes and ligands for odorant, vomeronasal and taste receptors. Nat. Rev. Neurosci., 2004, 5(4), 263-278 a.
[http://dx.doi.org/10.1038/nrn1365] [PMID: 15034552]

Pace, U.; Hanski, E.; Salomon, Y.; Lancet, D. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature, 1985, 316(6025), 255-258.
[http://dx.doi.org/10.1038/316255a0] [PMID: 3927168]

Abaffy, T.; Matsunami, H.; Luetje, C.W. Functional analysis of a mammalian odorant receptor subfamily. J. Neurochem., 2006, 97(5), 1506-1518.
[http://dx.doi.org/10.1111/j.1471-4159.2006. 03859.x] [PMID: 16606354]

Pace, U.; Lancet, D. Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons. Proc. Natl. Acad. Sci. USA, 1986, 83(13), 4947-4951.
[http://dx.doi.org/ 10.1073/pnas.83.13.4947] [PMID: 3088569]

Nakamura, T.; Gold, G.H. A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature, 1987, 325(6103), 442-444.
[http://dx.doi.org/10.1038/325442a0] [PMID: 3027574]

Sklar, P.B.; Anholt, R.R.; Snyder, S.H. The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J. Biol. Chem., 1986, 261(33), 15538-15543.
[PMID: 3536906]

Bockaert, J.; Pin, J.P. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J., 1999, 18(7), 1723-1729.
[http://dx.doi.org/10.1093/emboj/18.7.1723] [PMID: 10202136]

Malnic, B.; Hirono, J.; Sato, T.; Buck, L.B. Combinatorial receptor codes for odors. Cell, 1999, 96(5), 713-723.
[http://dx.doi.org/ 10.1016/S0092-8674(00)80581-4] [PMID: 10089886]

Krautwurst, D.; Yau, K.W.; Reed, R.R. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell, 1998, 95(7), 917-926.
[http://dx.doi.org/10.1016/S0092-8674(00)81716-X] [PMID: 9875846]

Floriano, W.B.; Vaidehi, N.; Goddard, W.A. III Making sense of olfaction through predictions of the 3-D structure and function of olfactory receptors. Chem. Senses, 2004, 29(4), 269-290.
[http://dx.doi.org/10.1093/chemse/bjh030] [PMID: 15150141]

Shirokova, E.; Schmiedeberg, K.; Bedner, P.; Niessen, H.; Willecke, K.; Raguse, J.D.; Meyerhof, W.; Krautwurst, D. Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. J. Biol. Chem., 2005, 280(12), 11807-11815.
[http://dx.doi.org/10.1074/jbc. M411508200] [PMID: 15598656]

Abaffy, T.; Matsunami, H.; Luetje, C.W. Functional analysis of a mammalian odorant receptor subfamily. J. Neurochem., 2006, 97(5), 1506-1518.
[http://dx.doi.org/10.1111/j.1471-4159.2006. 03859.x] [PMID: 16606354]

Grosmaitre, X.; Vassalli, A.; Mombaerts, P.; Shepherd, G.M.; Ma, M. Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice. Proc. Natl. Acad. Sci. USA, 2006, 103(6), 1970-1975.
[http://dx.doi.org/10.1073/pnas.0508491103] [PMID: 16446455]

Touhara, K.; Sengoku, S.; Inaki, K.; Tsuboi, A.; Hirono, J.; Sato, T.; Sakano, H.; Haga, T. Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl. Acad. Sci. USA, 1999, 96(7), 4040-4045.
[http://dx.doi.org/10. 1073/pnas.96.7.4040] [PMID: 10097159]

Dong, X.; Han, S.; Zylka, M.J.; Simon, M.I.; Anderson, D.J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 2001, 106(5), 619-632.
[http://dx.doi.org/10.1016/S0092-8674(01)00483-4] [PMID: 11551509]

Wilson, S.; Bergsma, D. Orphan G-protein coupled receptors: novel drug targets for the pharmaceutical industry. Drug Des. Discov., 2000, 17(2), 105-114.
[PMID: 11045900]

Baldwin, J.M. The probable arrangement of the helices in G protein-coupled receptors. EMBO J., 1993, 12(4), 1693-1703.
[http://dx.doi.org/10.1002/j.1460-2075.1993.tb05814.x] [PMID: 8385611]

Boekhoff, I.; Breer, H. Differential stimulation of second messenger pathways by distinct classes of odorants. Neurochem. Int., 1990, 17(4), 553-557.
[http://dx.doi.org/10.1016/0197-0186(90) 90043-S] [PMID: 20504658]

Katada, S.; Hirokawa, T.; Oka, Y.; Suwa, M.; Touhara, K. Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. J. Neurosci., 2005, 25(7), 1806-1815.
[http://dx.doi.org/10.1523/JNEUROSCI. 4723-04.2005] [PMID: 15716417]

Katada, S.; Hirokawa, T.; Touhara, K. Exploring the odorant binding site of a G-protein-coupled olfactory receptor. Curr. Comput. Aided Drug Des., 2008, 4, 123-131.
[http://dx.doi.org/10.2174/157340908784533247]

Wang, J.; Luthey-Schulten, Z.A.; Suslick, K.S. Is the olfactory receptor a metalloprotein? Proc. Natl. Acad. Sci. USA, 2003, 100(6), 3035-3039.
[http://dx.doi.org/10.1073/pnas.262792899] [PMID: 12610211]

Abaffy, T.; Malhotra, A.; Luetje, C.W. The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. J. Biol. Chem., 2007, 282(2), 1216-1224.
[http://dx.doi.org/10.1074/jbc.M609355200] [PMID: 17114180]

Wade, F.; Espagne, A.; Persuy, M.A.; Vidic, J.; Monnerie, R.; Merola, F.; Pajot-Augy, E.; Sanz, G. Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer. J. Biol. Chem., 2011, 286(17), 15252-15259.
[http://dx.doi.org/10.1074/jbc.M110.184580] [PMID: 21454689]

Park, P.S.; Filipek, S.; Wells, J.W.; Palczewski, K. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry, 2004, 43(50), 15643-15656.
[http://dx.doi.org/10.1021/bi047907k] [PMID: 15595821]

Duncan, R.R.; Bergmann, A.; Cousin, M.A.; Apps, D.K.; Shipston, M.J. Multi-dimensional time-correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) to detect FRET in cells. J. Microsc., 2004, 215(Pt 1), 1-12.
[http://dx.doi.org/10.1111/j.0022-2720.2004.01343.x] [PMID: 15230870]

Pfleger, K.D.; Eidne, K.A. Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem. J., 2005, 385(Pt 3), 625-637.
[http://dx.doi.org/10.1042/BJ20041361] [PMID: 15504107]

Kaupmann, K.; Malitschek, B.; Schuler, V.; Heid, J.; Froestl, W.; Beck, P.; Mosbacher, J.; Bischoff, S.; Kulik, A.; Shigemoto, R.; Karschin, A.; Bettler, B. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature, 1998, 396(6712), 683-687.
[http://dx.doi.org/10.1038/25360] [PMID: 9872317]

Milligan, G.; Wilson, S.; López-Gimenez, J.F. The specificity and molecular basis of α1-adrenoceptor and CXCR chemokine receptor dimerization. J. Mol. Neurosci., 2005, 26(2-3), 161-168.
[http://dx.doi.org/10.1385/JMN:26:2-3:161] [PMID: 16012189]

Hague, C.; Hall, R.A.; Minneman, K.P. Olfactory receptor localization and function: an emerging role for GPCR heterodimerization. Mol. Interv., 2004, 4(6), 321-322.
[http://dx.doi.org/10.1124/mi.4.6.4] [PMID: 15616160]

Neuhaus, E.M.; Gisselmann, G.; Zhang, W.; Dooley, R.; Störtkuhl, K.; Hatt, H. Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster. Nat. Neurosci., 2005, 8(1), 15-17.
[http://dx.doi.org/10.1038/nn1371] [PMID: 15592462]

Minic, J.; Persuy, M.A.; Godel, E.; Aioun, J.; Connerton, I.; Salesse, R.; Pajot-Augy, E. Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening. FEBS J., 2005, 272(2), 524-537.
[http://dx.doi.org/10.1111/j.1742-4658.2004.04494.x] [PMID: 15654890]

Pajot-Augy, E.; Crowe, M.; Levasseur, G.; Salesse, R.; Connerton, I. Engineered yeasts as reporter systems for odorant detection. J. Recept. Signal Transduct. Res., 2003, 23(2-3), 155-171.
[http://dx.doi.org/10.1081/RRS-120025196] [PMID: 14626444]

John, C. Olfaction. Leffingwell Reports, 2002, 2(1), 1-34.

Breer, H.; Boekhoff, I.; Tareilus, E. Rapid kinetics of second messenger formation in olfactory transduction. Nature, 1990, 345(6270), 65-68.
[http://dx.doi.org/10.1038/345065a0] [PMID: 2158631]

Farrens, D.L.; Altenbach, C.; Yang, K.; Hubbell, W.L.; Khorana, H.G. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science, 1996, 274(5288), 768-770.
[http://dx.doi.org/10.1126/science.274.5288.768] [PMID: 8864113]

Sheikh, S.P.; Zvyaga, T.A.; Lichtarge, O.; Sakmar, T.P.; Bourne, H.R. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature, 1996, 383(6598), 347-350.
[http://dx.doi.org/10.1038/383347a0] [PMID: 8848049]

Ballesteros, J.A.; Jensen, A.D.; Liapakis, G.; Rasmussen, S.G.; Shi, L.; Gether, U.; Javitch, J.A. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J. Biol. Chem., 2001, 276(31), 29171-29177.
[http://dx.doi.org/10.1074/jbc.M103747200] [PMID: 11375997]

Salom, D.; Lodowski, D.T.; Stenkamp, R.E.; Le Trong, I.; Golczak, M.; Jastrzebska, B.; Harris, T.; Ballesteros, J.A.; Palczewski, K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc. Natl. Acad. Sci. USA, 2006, 103(44), 16123-16128.
[http://dx.doi.org/10.1073/pnas.0608022103] [PMID: 17060607]

Kato, A.; Katada, S.; Touhara, K. Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain-of-function mutation. J. Neurochem., 2008, 107(5), 1261-1270.
[http://dx.doi.org/10.1111/j.1471-4159.2008.05693.x] [PMID: 18803693]

Kaupp, U.B. Olfactory signalling in vertebrates and insects: differences and commonalities. Nat. Rev. Neurosci., 2010, 11(3), 188-200.
[http://dx.doi.org/10.1038/nrn2789] [PMID: 20145624]

Wong, S.T.; Trinh, K.; Hacker, B.; Chan, G.C.; Lowe, G.; Gaggar, A.; Xia, Z.; Gold, G.H.; Storm, D.R. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron, 2000, 27(3), 487-497.
[http://dx.doi.org/10.1016/S0896-6273(00)00060-X] [PMID: 11055432]

Belluscio, L.; Gold, G.H.; Nemes, A.; Axel, R. Mice deficient in G(olf) are anosmic. Neuron, 1998, 20(1), 69-81.
[http://dx.doi.org/ 10.1016/S0896-6273(00)80435-3] [PMID: 9459443]

Brunet, L.J.; Gold, G.H.; Ngai, J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron, 1996, 17(4), 681-693.
[http://dx.doi.org/ 10.1016/S0896-6273(00)80200-7] [PMID: 8893025]

Zheng, J.; Zagotta, W.N. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron, 2004, 42(3), 411-421.
[http://dx.doi.org/10.1016/S0896-6273(04)00253-3] [PMID: 15134638]

Kato, A.; Touhara, K. Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization. Cell. Mol. Life Sci., 2009, 66(23), 3743-3753.
[http://dx.doi.org/10.1007/s00018-009-0111-6] [PMID: 19652915]

Schroeder, B.C.; Cheng, T.; Jan, Y.N.; Jan, L.Y. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell, 2008, 134(6), 1019-1029.
[http://dx.doi.org/10.1016/j.cell. 2008.09.003] [PMID: 18805094]

Yang, Y.D.; Cho, H.; Koo, J.Y.; Tak, M.H.; Cho, Y.; Shim, W.S.; Park, S.P.; Lee, J.; Lee, B.; Kim, B.M.; Raouf, R.; Shin, Y.K.; Oh, U. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature, 2008, 455(7217), 1210-1215.
[http://dx.doi.org/10.1038/nature07313] [PMID: 18724360]

Bradley, J.; Reisert, J.; Frings, S. Regulation of cyclic nucleotide-gated channels. Curr. Opin. Neurobiol., 2005, 15(3), 343-349.
[http://dx.doi.org/10.1016/j.conb.2005.05.014] [PMID: 15922582]

Liman, E.R.; Buck, L.B. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron, 1994, 13(3), 611-621.
[http://dx.doi.org/10.1016/0896-6273 (94)90029-9] [PMID: 7522482]

Prasad, B.C.; Reed, R.R. Chemosensation: molecular mechanisms in worms and mammals. Trends Genet., 1999, 15(4), 150-153.
[http://dx.doi.org/10.1016/S0168-9525(99)01695-9] [PMID: 10203825]

Reisert, J.; Lai, J.; Yau, K.W.; Bradley, J. Mechanism of the excitatory Cl- response in mouse olfactory receptor neurons. Neuron, 2005, 45(4), 553-561.
[http://dx.doi.org/10.1016/j.neuron.2005. 01.012] [PMID: 15721241]

Kurahashi, T.; Yau, K.W. Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature, 1993, 363(6424), 71-74.
[http://dx.doi.org/ 10.1038/363071a0] [PMID: 7683113]

Schild, D.; Restrepo, D. Transduction mechanisms in vertebrate olfactory receptor cells. Physiol. Rev., 1998, 78(2), 429-466.
[http://dx.doi.org/10.1152/physrev.1998.78.2.429] [PMID: 9562035]

Antunes, G.; Sebastião, A.M.; Simoes de Souza, F.M. Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium. PLoS One, 2014, 9(8), e105531.
[http://dx.doi.org/ 10.1371/journal.pone.0105531] [PMID: 25144232]

Kurahashi, T.; Menini, A. Mechanism of odorant adaptation in the olfactory receptor cell. Nature, 1997, 385(6618), 725-729.
[http://dx.doi.org/10.1038/385725a0] [PMID: 9034189]

Barnea, G.; O’Donnell, S.; Mancia, F.; Sun, X.; Nemes, A.; Mendelsohn, M.; Axel, R. Odorant receptors on axon termini in the brain. Science, 2004, 304(5676), 1468.
[http://dx.doi.org/10.1126/science.1096146] [PMID: 15178793]

Buck, L.B. The search for odorant receptors. Cell, 2004, 116(2)(Suppl.), S117-S119, 1, S119
[http://dx.doi.org/10.1016/S0092-8674(04)00051-0] [PMID: 15055598]

Eggan, K.; Baldwin, K.; Tackett, M.; Osborne, J.; Gogos, J.; Chess, A.; Axel, R.; Jaenisch, R. Mice cloned from olfactory sensory neurons. Nature, 2004, 428(6978), 44-49.
[http://dx.doi.org/10.1038/nature02375] [PMID: 14990966]

Benovic, J.L.; Kühn, H.; Weyand, I.; Codina, J.; Caron, M.G.; Lefkowitz, R.J. Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc. Natl. Acad. Sci. USA, 1987, 84(24), 8879-8882.
[http://dx.doi.org/10.1073/pnas.84.24.8879] [PMID: 2827157]

Lohse, M.J.; Benovic, J.L.; Codina, J.; Caron, M.G.; Lefkowitz, R.J. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science, 1990, 248(4962), 1547-1550.
[http://dx.doi.org/ 10.1126/science.2163110] [PMID: 2163110]

Boekhoff, I.; Inglese, J.; Schleicher, S.; Koch, W.J.; Lefkowitz, R.J.; Breer, H. Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. J. Biol. Chem., 1994, 269(1), 37-40.
[PMID: 8276821]

Peppel, K.; Boekhoff, I.; McDonald, P.; Breer, H.; Caron, M.G.; Lefkowitz, R.J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J. Biol. Chem., 1997, 272(41), 25425-25428.
[http://dx.doi.org/10.1074/jbc.272.41.25425] [PMID: 9325250]

Mashukova, A.; Spehr, M.; Hatt, H.; Neuhaus, E.M. Beta-arrestin2-mediated internalization of mammalian odorant receptors. J. Neurosci., 2006, 26(39), 9902-9912.
[http://dx.doi.org/10.1523/JNEUROSCI.2897-06.2006] [PMID: 17005854]

Neuhaus, E.M.; Mashukova, A.; Barbour, J.; Wolters, D.; Hatt, H. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J. Cell Sci., 2006, 119(Pt 15), 3047-3056.
[http://dx.doi.org/ 10.1242/jcs.03046] [PMID: 16820410]

Pelosi, P.; Pisanelli, A.M.; Badaccini, N.E.; Gagliardo, A. Binding of [3H]-2-isobutyl-3-methoxypyrazine to cow olfactory mucosa. Chem. Senses, 1981, 6, 77-85.
[http://dx.doi.org/10.1093/chemse/6.2.77]

Pes, D.; Pelosi, P. Odorant-binding proteins of the mouse. Comp. Biochem. Physiol. B Biochem. Mol. Biol., 1995, 112(3), 471-479.
[http://dx.doi.org/10.1016/0305-0491(95)00063-1] [PMID: 8529023]

Pelosi, P. Odorant-binding proteins. Crit. Rev. Biochem. Mol. Biol., 1994, 29(3), 199-228.
[http://dx.doi.org/10.3109/10409239409086801] [PMID: 8070277]

Pevsner, J.; Snynder, S.H. Odorant-binding protein; odorant transport function in the vertebrate nasal epithelium. Chem. Senses, 1990, 15, 217-222.
[http://dx.doi.org/10.1093/chemse/15.2.217]

Bignetti, E.; Cavaggioni, A.; Pelosi, P.; Persaud, K.C.; Sorbi, R.T.; Tirindelli, R. Purification and characterisation of an odorant-binding protein from cow nasal tissue. Eur. J. Biochem., 1985, 149(2), 227-231.
[http://dx.doi.org/10.1111/j.1432-1033.1985.tb08916. x] [PMID: 3996407]

Pevsner, J.; Trifiletti, R.R.; Strittmatter, S.M.; Snyder, S.H. Isolation and characterization of an olfactory receptor protein for odorant pyrazines. Proc. Natl. Acad. Sci. USA, 1985, 82(9), 3050-3054.
[http://dx.doi.org/10.1073/pnas.82.9.3050] [PMID: 2986147]

Mulla, M.Y.; Tuccori, E.; Magliulo, M.; Lattanzi, G.; Palazzo, G.; Persaud, K.; Torsi, L. Capacitance-modulated transistor detects odorant binding protein chiral interactions. Nat. Commun., 2015, 6, 6010.
[http://dx.doi.org/10.1038/ncomms7010] [PMID: 25591754]

Meierhenrich, U.J.; Golebiowski, J.; Fernandez, X.; Cabrol-Bass, D. The molecular basis of olfactory chemoreception. Angew. Chem. Int. Ed. Engl., 2004, 43(47), 6410-6412.
[http://dx.doi.org/10.1002/anie.200462322] [PMID: 15578781]

Charlier, L.; Cabrol-Bass, D.; Golebiowski, J. How does human odorant binding protein bind odorants? The case of aldehydes studied by molecular dynamics. C. R. Chim., 2009, 12, 905-910.
[http://dx.doi.org/10.1016/j.crci.2008.09.022]

Tegoni, M.; Ramoni, R.; Bignetti, E.; Spinelli, S.; Cambillau, C. Domain swapping creates a third putative combining site in bovine odorant binding protein dimer. Nat. Struct. Biol., 1996, 3(10), 863-867.
[http://dx.doi.org/10.1038/nsb1096-863] [PMID: 8836103]

Vincent, F.; Spinelli, S.; Ramoni, R.; Grolli, S.; Pelosi, P.; Cambillau, C.; Tegoni, M. Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes. J. Mol. Biol., 2000, 300(1), 127-139.
[http://dx.doi.org/10.1006/jmbi. 2000.3820] [PMID: 10864504]

Löbel, D.; Strotmann, J.; Jacob, M.; Breer, H. Identification of a third rat odorant-binding protein (OBP3). Chem. Senses, 2001, 26(6), 673-680.
[http://dx.doi.org/10.1093/chemse/26.6.673] [PMID: 11473933]

Löbel, D.; Marchese, S.; Krieger, J.; Pelosi, P.; Breer, H. Subtypes of odorant-binding proteins--heterologous expression and ligand binding. Eur. J. Biochem., 1998, 254(2), 318-324.
[http://dx.doi.org/10.1046/j.1432-1327.1998.2540318.x] [PMID: 9660186]

Wojnar, P.; Lechner, M.; Merschak, P.; Redl, B. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. J. Biol. Chem., 2001, 276(23), 20206-20212.
[http://dx.doi.org/10.1074/jbc.M101762200] [PMID: 11287427]

Munger, S.D.; Leinders-Zufall, T.; Zufall, F. Subsystem organization of the mammalian sense of smell. Annu. Rev. Physiol., 2009, 71, 115-140.
[http://dx.doi.org/10.1146/annurev.physiol.70.113006. 100608] [PMID: 18808328]

Spehr, M.; Spehr, J.; Ukhanov, K.; Kelliher, K.R.; Leinders-Zufall, T.; Zufall, F. Parallel processing of social signals by the mammalian main and accessory olfactory systems. Cell. Mol. Life Sci., 2006, 63(13), 1476-1484.
[http://dx.doi.org/10.1007/s00018-006-6109-4] [PMID: 16732428]

Lin, W.; Arellano, J.; Slotnick, B.; Restrepo, D. Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system. J. Neurosci., 2004, 24(14), 3703-3710.
[http://dx.doi.org/10.1523/JNEUROSCI.0188-04.2004] [PMID: 15071119]

Liberles, S.D.; Buck, L.B. A second class of chemosensory receptors in the olfactory epithelium. Nature, 2006, 442(7103), 645-650.
[http://dx.doi.org/10.1038/nature05066] [PMID: 16878137]

Wallrabenstein, I.; Kuklan, J.; Weber, L.; Zborala, S.; Werner, M.; Altmüller, J.; Becker, C.; Schmidt, A.; Hatt, H.; Hummel, T.; Gisselmann, G. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One, 2013, 8(2), e54950.
[http://dx.doi.org/10.1371/journal.pone.0054950] [PMID: 23393561]

Liberles, S.D. Trace amine-associated receptors: ligands, neural circuits, and behaviors. Curr. Opin. Neurobiol., 2015, 34, 1-7.
[http://dx.doi.org/10.1016/j.conb.2015.01.001] [PMID: 25616211]

Fulle, H.J. Vassar. R.; Foster, D.C.; Yang, R.B.; Axel, R.; Garbers, D.L. A receptor guanylul cyclase expressed. specifically in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 1995, 92, 3571-3575.
[http://dx.doi.org/10.1073/pnas.92.8.3571] [PMID: 7724600]

Gibson, A.D.; Garbers, D.L. Guanylyl cyclases as a family of putative odorant receptors. Annu. Rev. Neurosci., 2000, 23, 417-439.
[http://dx.doi.org/10.1146/annurev.neuro.23.1.417] [PMID: 10845070]

Borowsky, B.; Adham, N.; Jones, K.A.; Raddatz, R.; Artymyshyn, R.; Ogozalek, K.L.; Durkin, M.M.; Lakhlani, P.P.; Bonini, J.A.; Pathirana, S.; Boyle, N.; Pu, X.; Kouranova, E.; Lichtblau, H.; Ochoa, F.Y.; Branchek, T.A.; Gerald, C. Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. USA, 2001, 98(16), 8966-8971.
[http://dx.doi.org/ 10.1073/pnas.151105198] [PMID: 11459929]

Bunzow, J.R.; Sonders, M.S.; Arttamangkul, S.; Harrison, L.M.; Zhang, G.; Quigley, D.I.; Darland, T.; Suchland, K.L.; Pasumamula, S.; Kennedy, J.L.; Olson, S.B.; Magenis, R.E.; Amara, S.G.; Grandy, D.K. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol., 2001, 60(6), 1181-1188.
[http://dx.doi.org/10.1124/mol.60.6.1181] [PMID: 11723224]

Lindemann, L.; Hoener, M.C. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol. Sci., 2005, 26(5), 274-281.
[http://dx.doi.org/10.1016/j.tips.2005.03.007] [PMID: 15860375]

Shi, L.; Javitch, J.A. The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu. Rev. Pharmacol. Toxicol., 2002, 42, 437-467.
[http://dx.doi.org/10.1146/annurev.pharmtox.42.091101.144224] [PMID: 11807179]

Horowitz, L.F.; Saraiva, L.R.; Kuang, D.; Yoon, K.H.; Buck, L.B. Olfactory receptor patterning in a higher primate. J. Neurosci., 2014, 34(37), 12241-12252.
[http://dx.doi.org/10.1523/JNEUROSCI. 1779-14.2014] [PMID: 25209267]

Grus, W.E.; Zhang, J. Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis. Mol. Biol. Evol., 2008, 25(8), 1593-1601.
[http://dx.doi.org/10.1093/molbev/msn107] [PMID: 18460446]

Hashiguchi, Y.; Nishida, M. Evolution of trace amine associated receptor (TAAR) gene family in vertebrates: lineage-specific expansions and degradations of a second class of vertebrate chemosensory receptors expressed in the olfactory epithelium. Mol. Biol. Evol., 2007, 24(9), 2099-2107.
[http://dx.doi.org/10.1093/molbev/msm140] [PMID: 17634392]

Nei, M.; Niimura, Y.; Nozawa, M. The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity. Nat. Rev. Genet., 2008, 9(12), 951-963.

Zhang, J.; Pacifico, R.; Cawley, D.; Feinstein, P.; Bozza, T. Ultrasensitive detection of amines by a trace amine-associated receptor. J. Neurosci., 2013, 33(7), 3228-3239.
[http://dx.doi.org/10.1523/JNEUROSCI.4299-12.2013] [PMID: 23407976]

Greer, P.L.; Bear, D.M.; Lassance, J.M.; Bloom, M.L.; Tsukahara, T.; Pashkovski, S.L.; Masuda, F.K.; Nowlan, A.C.; Kirchner, R.; Hoekstra, H.E.; Datta, S.R. A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Cell, 2016, 165(7), 1734-1748.
[http://dx.doi.org/10.1016/j.cell.2016.05.001] [PMID: 27238024]

Hu, J.; Zhong, C.; Ding, C.; Chi, Q.; Walz, A.; Mombaerts, P.; Matsunami, H.; Luo, M. Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science, 2007, 317(5840), 953-957.
[http://dx.doi.org/10.1126/science. 1144233] [PMID: 17702944]

Juilfs, D.M.; Fülle, H.J.; Zhao, A.Z.; Houslay, M.D.; Garbers, D.L.; Beavo, J.A. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc. Natl. Acad. Sci. USA, 1997, 94(7), 3388-3395.
[http://dx.doi.org/ 10.1073/pnas.94.7.3388] [PMID: 9096404]

Leinders-Zufall, T.; Cockerham, R.E.; Michalakis, S.; Biel, M.; Garbers, D.L.; Reed, R.R.; Zufall, F.; Munger, S.D. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc. Natl. Acad. Sci. USA, 2007, 104(36), 14507-14512.
[http://dx.doi.org/10.1073/pnas.0704965104] [PMID: 17724338]

Meyer, M.R.; Angele, A.; Kremmer, E.; Kaupp, U.B.; Muller, F. A cGMP-signaling pathway in a subset of olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 2000, 97(19), 10595-10600.
[http://dx.doi.org/10.1073/pnas.97.19.10595] [PMID: 10984544]

Guo, D.; Zhang, J.J.; Huang, X.Y. Stimulation of guanylyl cyclase-D by bicarbonate. Biochemistry, 2009, 48(20), 4417-4422.
[http://dx.doi.org/10.1021/bi900441v] [PMID: 19331426]

Sun, L.; Wang, H.; Hu, J.; Han, J.; Matsunami, H.; Luo, M. Guanylyl cyclase-D in the olfactory CO₂ neurons is activated by bicarbonate. Proc. Natl. Acad. Sci. USA, 2009, 106(6), 2041-2046.
[http://dx.doi.org/10.1073/pnas.0812220106] [PMID: 19181845]

Chastrette, M. Trends in structure-odor relationships. SAR QSAR Environ. Res., 1997, 6(3-4), 215-254.
[http://dx.doi.org/10.1080/10629369708033253] [PMID: 9487700]

Laska, M.; Trolp, S.; Teubner, P. Odor structure-activity relationships compared in human and nonhuman primates. Behav. Neurosci., 1999, 113(5), 998-1007.
[http://dx.doi.org/10.1037/0735-7044. 113.5.998] [PMID: 10571482]

Ohloff, G.; Pickenhagen, W.; Kraft, P. Scent and Chemistry The molecular world of Odors, 1st ed; Wiley-VCH, 2001.

Dravnieks, A. Current status of Odour Theories Flavour Chemistry. Adv. Chem., 1969, 56, 29-52.
[http://dx.doi.org/10.1021/ba-1966-0056.ch002]

Demole, E.; Wuest, H. Synthèses stéréosélectives de deuxtrioxydes C18H30O3 stéréoisomères, d’ambréinolide et sclaréol-lactone a partir de derives du (+)-manool. Helv. Chim. Acta, 1969, 50, 1314-1322.
[http://dx.doi.org/10.1002/hlca.19670500514]

Zhang, X.; Rogers, M.; Tian, H.; Zhang, X.; Zou, D.J.; Liu, J.; Ma, M.; Shepherd, G.M.; Firestein, S.J. High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc. Natl. Acad. Sci. USA, 2004, 101(39), 14168-14173.
[http://dx.doi.org/10.1073/pnas.0405350101] [PMID: 15377787]

Feldmesser, E.; Olender, T.; Khen, M.; Yanai, I.; Ophir, R.; Lancet, D. Widespread ectopic expression of olfactory receptor genes. BMC Genomics, 2006, 7, 121.
[http://dx.doi.org/10.1186/1471-2164-7-121] [PMID: 16716209]

Jones, F.N.; Margaret, H. Modern Theories of Olfaction, a Critical Review. J. Psychol., 1953, 36, 207-241.
[http://dx.doi.org/10. 1080/00223980.1953.9712890]

Bourgeois, A.E.; Bourgeois, J.O. Theories of Olfaction: A Review. Interam. J. Psychol., 2017, 19-31.

Wendt, G.R. Somesthesis and the chemical senses. Annu. Rev. Psychol., 1952, 3, 105-130.
[http://dx.doi.org/10.1146/annurev.ps. 03.020152.000541] [PMID: 12977187]

Moncrieff, R.W. The characterization of odours. J. Physiol., 1954, 125(3), 453-465.
[http://dx.doi.org/10.1113/jphysiol.1954.sp005172] [PMID: 13212711]

Amoore, J.E. Molecular Basis of Odor; C.C. Thomas Pub.: Springfield, 1970.

Davies, J.T.; Taylor, F.H. The role of adsorption and molecular morphology in olfaction; the calculation of olfactory thresholds. Biol. Bull., 1959, 117, 222-238.
[http://dx.doi.org/10.2307/1538902]

Wright, R.H. The Sense of Smell; CRC Press: Boca Raton, 1982.

Moncrieff, R.W. The Chemical Senses; Wiley: New York, 1946.

Gasser, H.S. Olfactory nerve fibers. J. Gen. Physiol., 1956, 39(4), 473-496.
[http://dx.doi.org/10.1085/jgp.39.4.473] [PMID: 13295549]

Beck, L.H.; Miles, W.R. Some theoretical and experimental relationships between infra-red absorption and olfaction. Science, 1947, 106, 511.
[PMID: 20340842]

Morgan, C.T.; Stellar, E. Physiological Psychology; McGraw- Hill: New York, 1950, pp. 109-116.

Leffingwell, J.C. Comment in Gustation and Olfaction; Academic Press: NY, 1971.

Langenau, E.E. Olfaction and Taste; Rockefeller University Press: New York, 1967, Vol. III, .

Wright, R.H. Odour and molecular vibration. Nature, 1961, 190, 1101-1102.
[http://dx.doi.org/10.1038/1901101a0] [PMID: 5921179]

Young, C.W.; Pletcher, D.E.; Wright, N. On olfaction and infrared radiation theories. Science, 1948, 108(2807), 411-412.
[http://dx.doi.org/10.1126/science.108.2807.411-a] [PMID: 17782696]

Stemp, E.D.; Barton, J.K. Electron transfer between metal complexes bound to DNA: is DNA a wire? Met. Ions Biol. Syst., 1996, 33, 325-365.
[PMID: 8742848]

Turin, L. A spectroscopic mechanism for primary olfactory reception. Chem. Senses, 1996, 21(6), 773-791.
[http://dx.doi.org/10. 1093/chemse/21.6.773] [PMID: 8985605]

Geldard, F.A. Somesthesis and the chemical senses. Annu. Rev. Psychol., 1950, 1, 71-86.
[http://dx.doi.org/10.1146/annurev.ps.01. 020150.000443] [PMID: 14771867]

Mullins, L.J. Olfaction. Ann. N. Y. Acad. Sci., 1955, 62, 247-276.
[http://dx.doi.org/10.1111/j.1749-6632.1955.tb35354.x]

Amoore, J.E. Stereochemical theory of olfaction. Nature, 1963, 198, 271-272.
[http://dx.doi.org/10.1038/198271a0] [PMID: 14012641]

Topiol, S.; Sabio, M. X-ray structure breakthroughs in the GPCR transmembrane region. Biochem. Pharmacol., 2009, 78(1), 11-20.
[http://dx.doi.org/10.1016/j.bcp.2009.02.012] [PMID: 19447219]

Crasto, C.J. Computational Biology of Olfactory Receptors. Curr. Bioinform., 2009, 4(1), 8-15.
[http://dx.doi.org/10.2174/157489309787158143] [PMID: 21984880]

Peng, Y.; McCorvy, J.D.; Harpsøe, K.; Lansu, K.; Yuan, S.; Popov, P.; Qu, L.; Pu, M.; Che, T.; Nikolajsen, L.F.; Huang, X.P.; Wu, Y.; Shen, L.; Bjørn-Yoshimoto, W.E.; Ding, K.; Wacker, D.; Han, G.W.; Cheng, J.; Katritch, V.; Jensen, A.A.; Hanson, M.A.; Zhao, S.; Gloriam, D.E.; Roth, B.L.; Stevens, R.C.; Liu, Z.J. 5-HT_2C receptor structures reveal the structural basis of GPCR polypharmacology. Cell, 2018, 172(4), 719-730.e14.
[http://dx.doi.org/ 10.1016/j.cell.2018.01.001] [PMID: 29398112]

Wang, S.; Che, T.; Levit, A.; Shoichet, B.K.; Wacker, D.; Roth, B.L. Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature, 2018, 555(7695), 269-273.
[http://dx.doi.org/10.1038/nature25758] [PMID: 29466326]

Yang, Z.; Han, S.; Keller, M.; Kaiser, A.; Bender, B.J.; Bosse, M.; Burkert, K.; Kögler, L.M.; Wifling, D.; Bernhardt, G.; Plank, N.; Littmann, T.; Schmidt, P.; Yi, C.; Li, B.; Ye, S.; Zhang, R.; Xu, B.; Larhammar, D.; Stevens, R.C.; Huster, D.; Meiler, J.; Zhao, Q.; Beck-Sickinger, A.G.; Buschauer, A.; Wu, B. Structural basis of ligand binding modes at the neuropeptide Y Y₁ receptor. Nature, 2018, 556(7702), 520-524.
[http://dx.doi.org/10.1038/s41586-018-0046-x] [PMID: 29670288]

Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Le Trong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.; Miyano, M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science, 2000, 289(5480), 739-745.
[http://dx.doi.org/10.1126/science.289.5480.739] [PMID: 10926528]

Teller, D.C.; Okada, T.; Behnke, C.A.; Palczewski, K.; Stenkamp, R.E. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry, 2001, 40(26), 7761-7772.
[http://dx.doi.org/10.1021/bi0155091] [PMID: 11425302]

Cherezov, V.; Rosenbaum, D.M.; Hanson, M.A.; Rasmussen, S.G.; Thian, F.S.; Kobilka, T.S.; Choi, H.J.; Kuhn, P.; Weis, W.I.; Kobilka, B.K.; Stevens, R.C. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science, 2007, 318(5854), 1258-1265.
[http://dx.doi.org/10.1126/science.1150577] [PMID: 17962520]

Rasmussen, S.G.; Choi, H.J.; Rosenbaum, D.M.; Kobilka, T.S.; Thian, F.S.; Edwards, P.C.; Burghammer, M.; Ratnala, V.R.; Sanishvili, R.; Fischetti, R.F.; Schertler, G.F.; Weis, W.I.; Kobilka, B.K. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature, 2007, 450(7168), 383-387.
[http://dx.doi.org/10.1038/nature06325] [PMID: 17952055]

Strader, C.D.; Fong, T.M.; Tota, M.R.; Underwood, D.; Dixon, R.A.F. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem., 1994, 63, 101-132.
[http://dx.doi.org/10. 1146/annurev.bi.63.070194.000533] [PMID: 7979235]

Shacham, S.; Topf, M.; Avisar, N.; Glaser, F.; Marantz, Y.; Bar-Haim, S.; Noiman, S.; Naor, Z.; Becker, O.M. Modeling the 3D structure of GPCRs from sequence. Med. Res. Rev., 2001, 21(5), 472-483.
[http://dx.doi.org/10.1002/med.1019] [PMID: 11579443]

Vaidehi, N.; Floriano, W.B.; Trabanino, R.; Hall, S.E.; Freddolino, P.; Choi, E.J.; Zamanakos, G.; Goddard, W.A., III Prediction of structure and function of G protein-coupled receptors. Proc. Natl. Acad. Sci. USA, 2002, 99(20), 12622-12627.
[http://dx.doi.org/ 10.1073/pnas.122357199] [PMID: 12351677]

Eisenberg, D.; Weiss, R.M.; Terwilliger, T.C. The hydrophobic moment detects periodicity in protein hydrophobicity. Proc. Natl. Acad. Sci. USA, 1984, 81(1), 140-144.
[http://dx.doi.org/10.1073/pnas.81.1.140] [PMID: 6582470]

Floriano, W.B.; Vaidehi, N.; Goddard, W.A., III; Singer, M.S.; Shepherd, G.M. Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor. Proc. Natl. Acad. Sci. USA, 2000, 97(20), 10712-10716.
[http://dx.doi.org/10.1073/pnas.97.20.10712] [PMID: 11005853]

Floriano, W.B.; Nagarajan, V.; Goddard, W.A., III Methods and apparatus for predicting ligand binding interactions. U.S. Patent Application (California Institute of Technology reference number CIT 3192), November 30, 2001

Datta, D.; Vaidehi, N.; Xu, X.; Goddard, W.A., III Mechanism for antibody catalysis of the oxidation of water by singlet dioxygen. Proc. Natl. Acad. Sci. USA, 2002, 99(5), 2636-2641.
[http://dx.doi.org/10.1073/pnas.052709399] [PMID: 11880618]

Anselmi, C.; Buonocore, A.; Centini, M.; Facino, R.M.; Hatt, H. The human olfactory receptor 17-40: requisites for fitting into the binding pocket. Comput. Biol. Chem., 2011, 35(3), 159-168.
[http://dx.doi.org/10.1016/j.compbiolchem.2011.04.011] [PMID: 21704262]

Lai, P.C.; Singer, M.S.; Crasto, C.J. Structural activation pathways from dynamic olfactory receptor-odorant interactions. Chem. Senses, 2005, 30(9), 781-792.
[http://dx.doi.org/10.1093/chemse/bji070] [PMID: 16243965]

Lai, P.C.; Crasto, C.J. Beyond modeling: all-atom olfactory receptor model simulations. Front. Genet., 2012, 3, 61.
[http://dx.doi.org/10.3389/fgene.2012.00061] [PMID: 22563330]

Lai, P.C.; Guida, B.; Shi, J.; Crasto, C.J. Preferential binding of an odor within olfactory receptors: a precursor to receptor activation. Chem. Senses, 2014, 39(2), 107-123.
[http://dx.doi.org/10.1093/chemse/bjt060] [PMID: 24398973]

Liu, N.; Crasto, C.J.; Ma, M. Integrated olfactory receptor and microarray gene expression databases. BMC Bioinformatics, 2007, 8, 231.
[http://dx.doi.org/10.1186/1471-2105-8-231] [PMID: 17603910]

mdl.shsmu.edu.cn/ODORactor (Accessed on July 30, 2018)

Modena, D. Trentini, M.; Corsini, M.; Bombaci, A.; Giorgetti, A. Olfaction D.B: A database of olfactory receptors and their ligands. Adv. Life Sci., 2011, 1, 1-5.
[http://dx.doi.org/10.5923/j.als. 20110101.01]

Olender, T.; Nativ, N.; Lancet, D. HORDE: Comprehensive resource for olfactory receptor genomics. Methods Mol. Biol., 2013, 1003, 23-38.
[http://dx.doi.org/10.1007/978-1-62703-377-0_2] [PMID: 23585031]

Liu, X.; Su, X.; Wang, F.; Huang, Z.; Wang, Q.; Li, Z.; Zhang, R.; Wu, L.; Pan, Y.; Chen, Y.; Zhuang, H.; Chen, G.; Shi, T.; Zhang, J. ODO Ractor: a web server for deciphering olfactory coding. Bioinformatics, 2011, 27(16), 2302-2303.
[http://dx.doi.org/10.1093/bioinformatics/btr385] [PMID: 21700676]