Title:A Review of Neuroimaging Studies on Working Memory Paradigms in Patients with Bipolar Disorder
Volume: 18
Issue: 21
Author(s): Asen Beshkov*, Mariyan Topolov, Feryhan Ahmed-Popova and Stefan Sivkov
Affiliation:
- Department of Psychiatry and Medical Psychology, Faculty of Medicine, Medical University Plovdiv,Bulgaria
Keywords:
Brain technologies, Functional MRI, Working memory, Bipolar disorder, Endophenotype, Brain structures.
Abstract: New brain technologies including neuroimaging studies are powerful means for providing
new insights into clinical and cognitive neuroscience. Bipolar disorder is a severe chronic phasic mental
disease characterized by various cognitive dysfunctions. Working memory is one prominent domain of
cognitive impairment in bipolar disorder. Disruptions in working memory are observed even in
euthymic bipolar patients which makes it a potential endophenotypic marker for the disorder. Finding
such markers may help in providing firm neurobiological basis for psychiatric nosologies and symptomatic
presentations. This review aims to summarize some of the important aspects of findings from
functional magnetic resonance imaging studies on the activation of brain structures in relation to working
memory paradigms.
