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Current Medicinal Chemistry

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General Review Article

An Update on the Neurochemistry of Essential Tremor

Author(s): Félix Javier Jiménez-Jiménez *, Hortensia Alonso-Navarro, Elena García-Martín and José A.G. Agúndez

Volume 27, Issue 10, 2020

Page: [1690 - 1710] Pages: 21

DOI: 10.2174/0929867325666181112094330

Price: $65

Abstract

Background: The pathophysiology and neurochemical mechanisms of essential tremor (ET) are not fully understood, because only a few post-mortem studies have been reported, and there is a lack of good experimental model for this disease.

Objective: The main aim of this review is to update data regarding the neurochemical features of ET. Alterations of certain catecholamine systems, the dopaminergic, serotonergic, GABAergic, noradrenergic, and adrenergic systems have been described, and are the object of this revision.

Methods: For this purpose, we performed a literature review on alterations of the neurotransmitter or neuromodulator systems (catecholamines, gammaaminobutyric acid or GABA, excitatory amino acids, adenosine, T-type calcium channels) in ET patients (both post-mortem or in vivo) or in experimental models resembling ET.

Results and Conclusion: The most consistent data regarding neurochemistry of ET are related with the GABAergic and glutamatergic systems, with a lesser contribution of adenosine and dopaminergic and adrenergic systems, while there is not enough evidence of a definite role of other neurotransmitter systems in ET. The improvement of harmaline-induced tremor in rodent models achieved with T-type calcium channel antagonists, cannabinoid 1 receptor, sphingosine-1-phosphate receptor agonists, and gap-junction blockers, suggests a potential role of these structures in the pathogenesis of ET.

Keywords: Essential tremor, neurochemistry, GABA, glutamate, dopamine, noradrenaline, adrenaline, serotonin, adenosine, T-type calcium channels.

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