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General Review Article

自噬调节剂和神经炎症

卷 27, 期 6, 2020

页: [955 - 982] 页: 28

弟呕挨: 10.2174/0929867325666181031144605

价格: $65

摘要

背景：神经炎症在各种神经系统疾病的发生和发展中起着至关重要的作用。因此，各种研究集中于开发神经炎症抑制剂作为潜在的治疗工具。最近，自噬参与调节神经炎症引起了广泛的科学兴趣，越来越多的研究支持自噬受损在常见神经退行性疾病发病机理中的作用。 目的：本文的目的是回顾自噬在控制神经炎症中作用的最新研究。我们专注于利用哺乳动物细胞和动物模型评估不同自噬调节剂调节神经炎症的能力的研究。 方法：我们主要回顾了最近的研究，这些研究报告了自噬的抗神经炎特性。我们还简要讨论了一些研究，这些研究表明自噬调节剂在某些情况下会激活神经炎症。 结果：最近的研究报道了自噬调节剂的神经保护作用和抗神经炎症作用。我们讨论了这些药物可能的潜在作用机理及其作为针对神经系统疾病的治疗剂的潜在局限性。 结论：自噬激活剂是用于治疗涉及神经炎症的神经系统疾病的有前途的化合物。

关键词: 自噬，自噬调节剂，神经炎症，神经系统疾病，M2小胶质细胞，神经变性。

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