Title:Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations
Volume: 16
Issue: 3
Author(s): Dmitry L. Maslov*, Elena E. Balashova, Oxana P. Trifonova and Petr G. Lokhov
Affiliation:
- Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow,Russian Federation
Keywords:
Metabolomics, pharmacometabolomics, pharmacogenomics, personalized medicine, mass spectrometry,
metabolomics-based approach.
Abstract: Background: A patient-focused approach to treatment, where individual characteristics
provide the selection of optimal medication strategy for a particular patient, is
the trend of current clinical therapy. An application of advanced “omics” technologies,
which enable to detect the inter-individual variability in genomic, transcriptomic, proteomic,
and metabolomic levels is a perspective way to achieve such personalization.
Objective: In this review, the advantages of metabolomics-based approach as one of the
most promising and perspective for individualization of pharmacotherapy are demonstrated.
This approach provides a prediction of the inter-individual variability in drug response
and allows monitoring effectiveness of drug treatment, correcting it in account of
individual parameters of patients.
Method: Comparative analysis of metabolomics-based approach and the current methods
of drug treatment personalization are carried out.
Results: Advantages and limitations of the metabolomics-based approach were identified
and discussed.
Conclusion: The perspective ways for solution of limitations of the metabolomics-based
approach are considered.
