Title:Anti-cancer Nitrogen-Containing Heterocyclic Compounds
Volume: 22
Issue: 23
Author(s): Zahra Hosseinzadeh, Ali Ramazani*Nima Razzaghi-Asl
Affiliation:
- Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan,Iran
Keywords:
Anticancer, heterocyclic, nitrogen-containing heterocyclic, natural nitrogen-containing heterocyclic, synthetic nitrogencontaining
heterocyclic, chemotherapy agents.
Abstract: Cancer is one of the leading causes of death worldwide. Mutation of the cell
regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer
agents are the current therapy of cancer despite their side effects. The general area of
research relates to heterocyclic chemistry. The purpose of the article is to review the most
recent advances in nitrogen-containing heterocyclics as possible chemotherapy agents for
cancer. More than 90% of the novel drugs bear heterocyclics and among them, nitrogencontaining
heterocyclic compounds show superior pharmaceutical effect than non-nitrogen
compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant
and valuable group of molecules that play a chief and vital role in the metabolism
of living cells.
