Title:Inhibitory Role of Resveratrol in the Development of Profibrogenesis and Fibrosis Mechanisms
Volume: 18
Issue: 1
Author(s): Marzeea A. Raka, Abida Tisha, Salma Khan, Tasfiq Z. Paran, Nowshin Ahmed, Mohammad M. Mohib, Md. A.T. Sagor*Sarif Mohiuddin
Affiliation:
- Department of Pharmaceutical Sciences, School of Life Sciences, North South University, Dhaka- 1229,Bangladesh
Keywords:
Fibrosis, TGF-β, collagens, MAPK, NF-κB, Resveratrol.
Abstract: Background: Chronic and non-communicable diseases such as non-alcoholic
fatty liver diseases, non-alcoholic steatohepatitis, obesity, diabetes, cardiovascular dysfunctions,
renal insufficiency, alcoholism and other inflammation disorders often lead to
severe organ damage. Fibrosis, on the contrary, is a complex phenomenon that may turn
into critical conditions if not treated properly. Several biochemical pathways and signaling
molecules, for instance, TGF-β, ECM, MMPs, Collagens, MAPK, AP-1, SMAD and
NF-κB are responsible for the pathophysiology. In addition to these, inflammatory and
pro-inflammatory cytokines are also blamed to be responsible in catalyzing fibrogenesis.
Methods: The information was basically searched using PubMed, Google Scholar and
Science Direct and put all together to correlate fibrosis pathophysiology. Only recent
publications were targeted to show protective roles of Resveratrol in animal studies and
human subjects.
Findings: There is no effective treatment tactic available for curing fibrosis since multiple
factors are associated with its progression; hence, it remains a big question to be answered
by current healthcare associates. However, cell-based therapies have been showing
quite effective approaches and are being suggested to counter fibrotic conditions. It is,
however, highly expensive and complicated procedure and unfortunately, the availability
of the strategy is limited worldwide. On the other hand, Resveratrol, a naturally occurring
polyphenol which is largely being investigated in various animal models, cell cultures
and human trials and thereby found highly potential in preventing measure against fibrosis.
Conclusion: Our current study, therefore, tries to establish some molecular pathways
which are responsible for the progression of pro-fibrogenesis and fibrosis. Our findings
would also explore the possible inhibitory role of Resveratrol alongside fibrosis.
