Title:Therapeutic Apheresis in Metabolic Syndrome
Volume: 18
Issue: 1
Author(s): V.A. Voinov*
Affiliation:
- I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg,Russian Federation
Keywords:
Metabolic syndrome, diabetes, diabetic foot, diabetic nephropaty, retinopathy, plasmapheresis.
Abstract: Background: The metabolic syndrome unites three pathologies of the person –
obesity, arterial hypertension and diabetes. In recent years the progressing of such distribution
covering from 2.5% to 3.8% of the population with increase twice each 10-15
years is noted. Even at maintenance of level of sugar at diabetes accumulation of the secondary
metabolites breaking small vessels isn't excluded. At the same time many lifeendangering
complications develop.
Objective: To identify the possibilities of plasmapheresis in the prevention and treatment
of complications of metabolic syndrome.
Method: Analysis of the world literature data on complications of metabolic syndrome
and methods of their treatment.
Results: At metabolic syndrome the frequency of strokes and myocardial infarctions
there is twice more often than in population. For 5-9 years the general life expectancy decreases.
Disorders of microcirculation at diabetes lead to a retinopathy with total loss of
sight, a nephropathy from the outcome in a renal failure, to polyneuropathy and diabetic
foot syndrome with high risk of high level amputations of the lower extremities. At the
same time medicamentous therapy is not able to prevent such complications and almost
only way of removal of these pathological metabolites is therapeutic apheresis, mainly
the plasmapheresis. Data from our own studies confirm the effectiveness of such tactics.
Conclusion: Plasmapheresis has to be applied not only to the correction of already critical
conditions, but also to their prevention.
