Title:Docking Studies and Stereo Quality Assessment of Glucose Transporter Member-4 (GLUT4)
Volume: 18
Issue: 1
Author(s): Abraham Peele Karlapudi*, Venkateswarulu T.C., Vamsi Lohit Kanumuri, Krupanidhi Srirama and Vidya Prabhakar Kodali
Affiliation:
- Department of Biotechnology, Vignan`s Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh-522213,India
Keywords:
GLUT4, SWISS-MODEL, docking, ATP, metformin, homeostasis.
Abstract: Background: Homeostasis of blood glucose concentration is a physiological
phenomenon that is tightly regulated in humans and acts as a major cellular mechanism
that decreases blood glucose during insulin-stimulated glucose transport. GLUT4 assumes
a significant role in managing entire body glucose homeostasis. Recent research
has found that overexpression of GLUT4 reduces glucose intolerance and diabetes. Interestingly,
reduction of GLUT4 by inhibiting glucose transport has been found to have a
powerful chemotherapeutic impact on myeloma. In order to further examine such interactions,
a high-resolution crystal structure would be particularly useful. A homology model
was produced for GLUT4 to screen for drug-like compounds and other docking complex
connections.
Conclusion: Our study provides further data for determining the role of GLUT controllers
used to target glucose transport. Clarification of the three-dimensional structure of
these transporters utilizing the steady, powerful and highly precise SWISS-MODEL protein
structure prediction server will fundamentally help in the advancement of novel
medications. The predicted model protein, GLUT4, demonstrated a comparable affinity
for ATP and with inhibitor metformin binding motifs.
