Title:Cariprazine in Bipolar Depression and Mania: State of the Art
Volume: 17
Issue: 10
Author(s): Marianna Mazza*, Giuseppe Marano, Gianandrea Traversi, Valentina Carocci, Benedetta Romano and Luigi Janiri
Affiliation:
- Institute of Psychiatry and Psychology, Department of Geriatrics, Neuroscience and Orthopedics, Fondazione Policlinico Universitario A. Gemelli IRCSS, Universita Cattolica del Sacro Cuore, Rome,Italy
Keywords:
Cariprazine, D3 receptor, bipolar disorder, bipolar mania, bipolar depression, psychiatric disease.
Abstract: Background & Objective: Cariprazine is a piprazine derivative approved by the FDA in
2015 for the treatment of schizophrenia and bipolar manic or mixed episodes in adults. High affinity
for D3 dopamine receptors and observed actions on 5HT1A, 5HT2A and alpha 1B receptors differentiate
it pharmacologically from other antipsychotics. This review is a comprehensive and thorough
summary of the most important findings on cariprazine use in bipolar mania and depression. Pharmacokinetics,
pharmacogenetics, tolerability and safety adverse effects are discussed in this paper.
Results & Conclusion: Moreover, the results from pivotal clinical trials are presented. Cariprazine represents
an additional option for clinicians to treat patients with bipolar disorder. It shows a unique pharmacological
profile and has demonstrated in randomized clinical trials efficacy and general tolerability compared
to placebo in bipolar mania and seem to be a promising therapeutic option for bipolar depression.
