Title:Neuroprotective Effects of Heat Shock Protein70
Volume: 17
Issue: 10
Author(s): Fatemeh Mohammadi, Navid Nezafat, Manica Negahdaripour, Fatemeh Dabbagh, Afshin Borhani Haghghi, Sedigheh Kianpour, Mehrzad Banihashemi and Younes Ghasemi*
Affiliation:
- Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz,Iran
Keywords:
Anti-apoptotic, anti-inflammatory, anti-necrotic, chaperone, heat shock protein, HSP70, stroke.
Abstract: Background & Objective: Heat Shock Proteins (HSPs) increase response to many stresses
in cells. Stroke is a neural shock that leads to the destruction of a large number of brain cells, whereas
induction and expression of HSPs can decrease the amount of damage, and in some conditions can
cure damaged cells. HSP70 family is considered as the most important member of HSPs in normal and
stress condition of cells. They are strongly up-regulated by stresses and have protective roles in under
stressed cells. Therefore, in this review, we briefly consider the association between HSP70 and
stroke. We searched in Pubmed and Scopus databases using the specified keywords and selected the
articles based on the certain association between HSP70 and stroke. HSP70 protects cells from damage
through a variety of cellular and biochemical processes such as chaperone function, anti-apoptotic,
anti-necrotic and anti-inflammatory mechanisms.
Conclusion: Protective effects of HSP70 in neurodegenerative shocks are illustrated in the review, and
it can be concluded that the induction of HSP70 in stresses can be considered as a therapeutic factor,
although it needs further studies.
