Title:The Prognostic Value of Cardiac Troponin I in Acute Exacerbation Phase of Chronic Obstructive Pulmonary Disease
Volume: 14
Issue: 3
Author(s): Hanieh Raji, Ahmad Valipour, Masoud Moradi, Maryam Dastoorpoor, Mehrdad Dargahi Malamir*Alireza Ghanbaran
Affiliation:
- Department of Pulmonology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran
Keywords:
Cardiac troponin I, chronic obstructive pulmonary disease, survival, cardiovascular disease.
Abstract: Background: Troponin is a specific marker for myocardial necrotic injury. Troponin
elevations can also occur in other diseases like chronic obstructive pulmonary disease (COPD) and
may be useful to predict mortality. The purpose of the present study was to assess the association
between circulating cTnI and prognosis among patients with COPD exacerbation without the overt
cardiovascular disease.
Methods: In descriptive-analytical cross-sectional study 180 patients admitted to Imam Khomeini
hospital with acute exacerbation of COPD were included and cTnI was assayed. Demographic data,
clinical symptoms and signs, arterial blood gas, electrocardiogram/ echocardiography, spirometry,
hospitalization ward, length of hospital stay and patient’s status including discharge or death were
recorded.
Results: Among 180 patients, 135 (75%) were men and 45 (25%) were women. Cardiac troponin I
was negative in 117 (65%) patients and positive in 63 (35%) patients. The median survival rate was
16±2.80 and 16±4.12 days for troponin positive and negative patients respectively, indicating no
significant relationship between survival and the positive or negative of cardiac troponin I.
Conclusion: cTnI can be used as a marker to identify high-risk patients during acute exacerbation of
COPD.
