Title:The Impact of Phytosterols on the Healthy and Diseased Brain
Volume: 26
Issue: 37
关键词:
植物甾醇,胆固醇,中枢神经系统,多发性硬化症,阿尔茨海默氏病,附加疗法。
摘要: The central nervous system (CNS) is the most cholesterol-rich organ in mammals.
Cholesterol homeostasis is essential for proper brain functioning and dysregulation of
cholesterol metabolism can lead to neurological problems. Multiple sclerosis (MS) and Alzheimer’s
disease (AD) are examples of neurological diseases that are characterized by a disturbed
cholesterol metabolism. Phytosterols (PS) are plant-derived components that structurally
and functionally resemble cholesterol. PS are known for their cholesterol-lowering
properties. Due to their ability to reach the brain, researchers have started to investigate the
physiological role of PS in the CNS. In this review, the metabolism and function of PS in
the diseased and healthy CNS are discussed.