Title:Application of Electrospinning Strategy on Cartilage Tissue Engineering
Volume: 13
Issue: 7
Author(s): Yao Liu, Li Liu, Zhi Wang, Guangsen Zheng, Qianming Chen and En Luo*
Affiliation:
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu,China
Keywords:
Cartilage tissue engineering, electrospinning, strategies, application, articular cartilage lesions, biomaterials.
Abstract: Cartilage, constituted with a relatively hypocellular structure and lacking of neural and vascular
connections, is not a well self-repairing tissue. Cartilage tissue engineering involving bulk of
biomaterials has been put forward as a strategy for articular cartilage lesions. The most complicated
issue for cartilage repairing is to simulate the highly hierarchical structure, extracellular matrix (ECM)
composition and even mechanical features. Electrospinning can produce flexible, dense fibrous membranes
with moderate mechanical properties and biological features with different constitution of
polymer, orientation, diameter and morphology of fibers, or cooperation forms with other strategies. In
our review, four classes are mentioned for cartilage tissue engineering and kinds of biomaterials to be
utilized.
