Title:Free Fatty Acids: Circulating Contributors of Metabolic Syndrome
Volume: 16
Issue: 1
Author(s): Chase Suiter, Santu K. Singha, Rozita Khalili and Zia Shariat-Madar*
Affiliation:
- Department of Biomolecular Sciences Division of Pharmacology, The University of Mississippi, Mississippi 38677-1848,United States
Keywords:
Cardiovascular disease, free fatty acids, metabolic syndrome, morbidity, mortality, monosaturated fatty acids.
Abstract: Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly,
the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical
studies indicate that increased Free Fatty Acids (FFAs) are involved in the pathogenesis of insulin
resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting
and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues
within the cardiovascular system and increased plasma concentrations of FFAs has been reported.
The importance of reduction in the consumption of dietary fatty acids along with the identification of
dysregulated genes responsible for persistent increased FFAs uptake and mitochondrial -oxidation has
been increasingly recognized. This review discusses the current empirical understanding of the different
types of fatty acids and their metabolism and functions both in physiological and pathophysiological
conditions. We also discuss in detail about the molecular and pathophysiological basis of increased
FFAs, which augments Cardiovascular Disease (CVD).
