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Review Article

多功能介孔二氧化硅纳米粒子的癌症治疗和成像。

卷 26, 期 31, 2019

页: [5745 - 5763] 页: 19

弟呕挨: 10.2174/0929867325666180501101044

价格: $65

摘要

背景：癌症是一种广泛的疾病，死亡率很高。流行的常规治疗包括化学疗法，放射线和手术切除。然而，这些治疗给患者带来许多毒性问题，这主要是由于其非选择性的性质，这引起了耐药性和严重的副作用。 目标：在这方面，纳米技术被称为是一项智能技术，可为系统提供将药物靶向特定部位的能力。随着纳米技术的使用，产生了广泛用作药物递送载体的各种纳米材料用于生物医学应用。在各种多样化的纳米载体中，介孔二氧化硅纳米颗粒（MSN）由于其结构特征，较大的表面积，可调节的孔径，良好的热稳定性和化学稳定性，出色的生物相容性以及易于表面修饰而备受关注。此外，可以通过各种刺激反应看门人系统调整从MSN释放的药物。 MSN的有序结构非常适合通过控制的递送负载大量药物分子，从而通过增强的渗透性和保留作用或表面修饰进一步靶向癌组织，它也可以被各种配体主动靶向。 方法：这篇综述文章重点介绍了MSNs在刺激反应药物递送，免疫治疗以及癌症治疗能力方面的常用合成方法和最新进展。 结论：尽管MSNs正成为用于更有效和更安全的癌症治疗的有希望的工具，但是，还需要进行更多的翻译研究以探索其在临床环境中的多功能性。

关键词: 纳米技术，介孔二氧化硅纳米颗粒，治疗，药物输送，癌症治疗，生物降解性。

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