Title:PRDM14: A Potential Target for Cancer Therapy
Volume: 18
Issue: 10
Author(s): Mengting Ou, Shun Li and Liling Tang*
Affiliation:
- Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044,China
Keywords:
PRDM14, oncogene, chemotherapeutic resistance, PRDM family, molecular therapeutic target, cancer therapy.
Abstract: PRDM14 belongs to the PR domain-containing (PRDM) family. Although a precise understanding
focused on the function of PRDM14 to maintain stemness and pluripotency in embryonic
stem cells via epigenetic mechanisms, growing experimental evidence has been linked
PRDM14 to human cancers. In adults, PRDM14 has low expression in human tissues. Aberrant
PRDM14 expression is connected with various malignant histological types and solid cancers, where
PRDM14 can act as a driver of oncogenic processes. Overexpression of RPDM14 enhanced cancer
cells growth and reduced cancer cells sensitive to chemotherapeutic agents. Reducing the expression
of PRDM14 in cancer cells can enhance the therapeutic sensitivity of drugs to cancer cells, suggesting
that aberrant PRDM14 may have a carcinogenic characteristic in tumor therapy and as a new
molecular target. This review summarizes the structure and oncogenic properties of PRDM14 in different
malignancies and suggests that PRDM14 may be a potential therapeutic molecular target for
tumor treatment.
