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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Systematic Review Article

抗原特异性免疫治疗在非小细胞肺癌患者治疗中的疗效和安全性:系统评价和Meta分析

卷 19, 期 3, 2019

页: [199 - 209] 页: 11

弟呕挨: 10.2174/1568009618666180430124738

价格: $65

摘要

背景和目的:我们进行了系统评价和荟萃分析,以评估抗原特异性免疫治疗(Belagenpumatucel-L,MAGE-A3,L-BLP25和TG4010)治疗非小患者的疗效和安全性。细胞肺癌(NSCLC)。 方法:对PubMed,Embase和Web of Science进行全面的文献检索。符合条件的研究是接受抗原特异性免疫治疗的NSCLC患者的临床试验。计算总生存(OS),无进展生存期(PFS)的95%置信区间(95%CI)的汇总风险比(HR)。计算总体反应率(ORR)和不良事件发生率的汇总风险比(RR)。 结果:共纳入6项随机对照试验(RCT),共4,806例患者。汇总结果显示,抗原特异性免疫治疗并未显着延长OS(HR = 0.92,95%CI:0.83,1.01; P = 0.087)和PFS(HR = 0.93,95%CI:0.85,1.01; P = 0.088) ,但ORR得到改善(RR = 1.72,95%CI:1.11,2.68; P = 0.016)。基于治疗药物的亚组分析显示,tecemotide与OS显着改善相关(HR = 0.85,95%CI:0.74,0.99; P = 0.03)和PFS(HR = 0.70,95%CI:0.49,0.99, P = 0.044); TG4010与PFS的改善相关(HR = 0.87,95%CI:0.75,1.00,P = 0.058)。此外,接受抗原特异性免疫治疗的NSCLC患者的不良事件发生率显着高于其他治疗组(RR = 1.11,95%CI:1.00,1.24; P = 0.046)。 结论:我们的研究证明了tecemotide和TG4010在NSCLC治疗中的临床生存益处。但是,这些证据可能受到潜在偏见的限制。因此,需要进一步开展良好的大规模随机对照试验来验证我们的研究结果。

关键词: 非小细胞肺癌,抗原特异性免疫治疗,荟萃分析,汇总风险比,TG4010,T细胞活性。

图形摘要
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