Title:Inhibition of Chlamydia trachomatis Growth During the Last Decade: A Mini-Review
Volume: 18
Issue: 16
Author(s): Nawal Serradji*, Thi Huyen Vu, Hyunjoon Kim, Jayanth Panyam and Philippe Verbeke
Affiliation:
- Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, CNRS UMR 7086, 15 rue Jean-Antoine de Baif, F-75205 Paris Cedex,France
Keywords:
Gram-negative bacteria, inclusion, infection, inhibition, nanoparticles, Chlamydia trachomatis.
Abstract: Chlamydia trachomatis is responsible for the most frequent sexually transmitted bacterial
infection in the world and for trachoma, the world's leading infectious cause of blindness. Genital
chlamydial infection is very common among sexually active young people, and when untreated, leads
to serious complications. No vaccine is yet available for this bacterial infection. Although Chlamydia
resistance to antibiotics is rarely observed in vivo, studies showed that 10-20% of patients remain infected
at the end of antibiotherapy, without being reinfected. The present review gives a global and
comprehensive overview of the different targets and the related inhibitors proposed during the last decade,
with a view to limiting the growth of this human pathogen. Metallic and polymeric nanoparticles
in this field are also briefly presented.
