Title:Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review
Volume: 18
Issue: 17
Author(s): Shalki Choudhary, Om Silakari*Pankaj Kumar Singh
Affiliation:
- Molecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002,India
Keywords:
Thiazine, antimicrobial, antifungal, antimalarial, anticancer, thiazine scaffold.
Abstract: Nitrogen and sulphur based heterocyclic molecules have gained significant attention owing
to their broad spectrum pharmacological profiles. Thiazine is one of such promising scaffolds which
has been widely utilized in the synthesis of compounds that possess interesting biological profile including
anti-proliferative, anti-bacterial, antipsychotic, analgesic, anti-inflammatory, antifungal and
antiviral activities. The current review focuses on the chemistry of thiazine and its derivatives along
with potential pharmacological activities reported for these in scientific literature. Multifaceted pharmacological
profile of thiazine derivatives provides new aspects for the design of superior medicinally
active agents.
