Title:The Role of IRE1 Signaling in the Central Nervous System Diseases
Volume: 16
Issue: 9
Author(s): Haibo Ni, Qin Rui, Di Li*, Rong Gao and Gang Chen
Affiliation:
- Department of Translational Medicine Center, The First People`s Hospital of Zhangjiagang City, Suzhou, Jiangsu,China
Keywords:
Inositol-requiring enzyme 1, X box-binding protein 1, diseases, central nervous system, Alzheimer`s disease, Parkinson`s
disease, ischemic stroke.
Abstract: The accumulation of misfolded or unfolded proteins in endoplasmic reticulum (ER) lumen
results in the activation of an adaptive stress process called the unfolded protein response
(UPR). As the most conserved signaling branch of the UPR, Inositol-requiring enzyme 1 (IRE1)
possesses both Ser/Thr kinase and RNase activities operating as major stress sensors, mediating
both adaptive and pro-apoptotic pathways under ER stress. Over the last three decades, a mounting
body of evidence has shown that IRE1 signaling dysfunction is involved in the pathology of various
neurological disorders. Targeting this pathway has emerged as a promising therapeutic strategy
against these diseases. In this review, we provide a general overview about the expression and
physiological function of IRE1 signaling and its pathophysiological roles in the central nervous
system diseases.
