Title:Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis
Volume: 13
Issue: 5
Author(s): Yue Li, Daxiang Jin*, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren and Zenglin Xiao
Affiliation:
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou,China
Keywords:
MSCs, exosomes, osteoporosis, therapeutic, pathogenesis, bone mass.
Abstract: Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration
in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology
of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and
osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis,
inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the
recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based
tissue engineering therapy of osteoporosis. Growing evidence showed that paracrine effect has been
considered as the predominant mechanism for the role of MSCs in tissue repair. Recently, many studies
have proposed that MSCs-derived exosomes are effective for a variety of diseases like cancer, cardiovascular
diseases, etc. However, whether the MSCs-derived exosomes could serve as a novel therapeutic
tool for osteoporosis has not clearly described. In this review, we summarize the MSCs-derived
exosomes and the relationship with osteogenesis, osteoclast differentiation, angiogenesis, immune
processes and miRNAs. Finally, we suggest that MSCs-derived exosomes might be a promising therapeutic
method for osteoporosis in the future.
