Title:Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes
Volume: 19
Issue: 13
Author(s): Caroline F. Baldo, Luiza M. Silva, Livia Arcencio, Agnes A.S. Albuquerque, Andrea C. Celotto, Anibal Basile-Filho and Paulo R.B. Evora*
Affiliation:
- Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP,Brazil
Keywords:
Methylene blue, cGMP, nitric oxide, circulatory shock, neuroprotection, anaphylaxis, poisoning.
Abstract: Evidence-based review of the existing literature ultimately recommends stocking of Methylene
Blue (MB) as an emergency antidote in the United States. The same is reported around the
world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote
required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP
system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role
of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3)
Anaphylaxis and, 4) Overdose and poisoning.
