Title:Synthesis, In Silico and Antifungal Studies of Novel Thiophene Analogues Containing Pyrazole Ring
Volume: 15
Issue: 11
Author(s): Helmi M. Al-Maqtari, Joazaizulfazli Jamalis*, Subhash Chander, Hasnah M. Sirat , Shivalingegowda Naveen, Neratur K. Lokanath, Siti P.M. Bohari, Deepak P. Bhagwat and Murugesan Sankaranarayanan
Affiliation:
- Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor,Malaysia
Keywords:
Pyrazole, thiophene, antifungal, drug likeness, chalcone, synthesis.
Abstract: Background: In the current study, a series of novel thiophene chalcones (3a-g) and pyrazole
containing thiophene derivatives (6a-g) were designed as potential anti-fungal agents and
evaluated in silico for drug-likeness behavior.
Methods: The titled compounds were synthesized using Claisen–Schmidt reaction of 3-methyl-2-
thiophenecarboxaldehyde (1) with several acetophenone derivatives (2a-g) followed by cyclization
reactions using hydrazine hydrate to form new compounds (6a-g) in good to excellent yield. All the
synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis.
All the synthesized chalcones (3a-g) and pyrazole derivatives (6a-g) were screened for antifungal
potency using Candida albicans (MTCC 3958) and Aspergillus niger (MTCC 9933) using fluconazole
as standard drug.
Results & Conclusion: The assay results revealed interesting finding that, compound 6c showed
significant activity against both the tested fungal strains.
