Title:A Review on Camptothecin Analogs with Promising Cytotoxic Profile
Volume: 18
Issue: 13
Author(s): Sk. Abdul Amin, Nilanjan Adhikari, Tarun Jha*Shovanlal Gayen*
Affiliation:
- Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, P. O. Box 17020, Jadavpur University, Kolkata 700032, West Bengal,India
- Laboratory of Drug Design and Discovery, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar 470003, Madhya Pradesh,India
Keywords:
Camptothecin, homocamptothecin, topoisomerase, cytotoxicity, cancer cell lines, structure-activity relationship, quantitative
structure-activity relationship.
Abstract: Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of
alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a
variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task
to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential
as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be
clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted
extensively to get a detail insight about the structure-property relationships as well as different quantitative
structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial
for designing newer CPT analogs in future.
