Title:In-Vitro Drug Dissolution Studies in Medicinal Compounds
Volume: 25
Issue: 33
关键词:
溶出度试验，固体剂型，分析，USP仪器，药物，验证
摘要: After oral administration, drug absorption from solid dosage forms depends on the
release of the drug active compounds from the dosage form, the dissolution or solubilization
of the drug under physiological conditions, and the permeability across the gastrointestinal
tract. Dissolution testing is an essential part of designing more effective solid dosage forms
in pharmaceutical industry. Moreover, dissolution testing contributes to the selection of appropriate
formulation excipients for improving the dosage form efficiency. This study aims
to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present
a comprehensive outlook of recent trends. In doing that the previous studies in the literature
are summarized in the form of a table to demonstrate the apparatuses used for dissolution
testing, the media in which the solid dosage form is dissolved, the method preferred for
analysis from dissolution media, the conditions of analyses and the results obtained.
