Title:2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview
Volume: 18
Issue: 10
Author(s): Pramod Singh*, Jitendra Singh, Geeta J. Pant*Mohan S.M. Rawat
Affiliation:
- Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India
- Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India
Keywords:
Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.
Abstract: Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as
medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic
and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer,
antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides,
fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known
brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in
synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines
have also been investigated by several research groups. In this review, most of the synthesized and reported
nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation
and structure-reactivity are discussed.
