Title:Bile Acid Derivatives: From Old Molecules to a New Potent Therapeutic Use: An Overview
Volume: 25
Issue: 30
Author(s): Marine Blanchet and Jean Michel Brunel*
Affiliation:
- Centre de Recherche en Cancerologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Universite, UM 105; Inserm, U1068, F-13009, Marseille,France
Keywords:
Bile salts, bile acid conjugated, bile acid derivatives synthesis, antimicrobial agents, anticancer agents,
antiparasitic agents.
Abstract: Bile acids or bile salts, belong to a large family of biological steroid derivatives found predominantly
in the bile of mammals and other vertebrates. These amphipathic molecules possess numerous functions,
including eliminating cholesterol from the body, driving the flow of bile to eliminate catabolites,
emulsifying fat-soluble vitamins to enable their absorption, aiding in motility and in reducing the bacteria
flora found in the small intestine and biliary tract. In this review, we investigate progress towards synthetic
bile acid derivatives, with special emphasis on how they might be used for various biological applications
and the challenges that remain in developing these compounds as potent drugs of the future especially in
the field of microbiology (antimicrobial activities) and cancer (anticancer agents). We will emphasize the
fact that even few researches are devoted around these peculiar structures. All the researches pointed out
the important potential of such derivatives for the design of new classes of drugs.
