Title:Oral Mucosal Stem Cells, Human Immature Dental Pulp Stem Cells and Hair Follicle Bulge Stem Cells as Adult Stem Cells Able to Correct Limbal Stem Cell Deficiency
Volume: 13
Issue: 5
Author(s): Nada T. Hassan*Neveen Ahmed AbdelAziz
Affiliation:
- Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University, Cairo,Egypt
Keywords:
Limbal stem cell deficiency (LSCD), Adult stem cells (ASC), oral mucosal epithelial stem cells (OMESCs), human
imature dental pulp stem cells (hIDPSCs), Hair follicle (HF) bulge stem cells, corneal transplant.
Abstract: Background: Adult stem cells are somatic stem cells distributed all over the body. They
represent a promising future for regenerative medicine because of their multiple advantages as they are
widely available, accessible, easily stored and manipulated to a wide range of cells and with minimal
invasive extraction.
Objective: This review describes three examples of adult stem cells: oral mucosal epithelial stem cells,
human immature dental pulp stem cells and hair follicle bulge stem cells that show an ability to correct
limbal stem cell deficiency, their isolation and cultivation methods, feeder layers, carriers, markers
expressed, successfulness to regenerate the ocular surface and mimic the corneal function in LSCD.
Conclusion: Although hair follicle bulge stem cells and human immature dental pulp stem cells are a
promising adult stem cell source to correct limbal stem cell deficiency, but the published research
evaluating this ability is limited. Therefore, this article emphasize further research in this area.
