Title:LASP1 in Tumor and Tumor Microenvironment
Volume: 17
Issue: 8
Author(s): Z. Hu, X. Wang, Y. Cui, C. Li and S. Wang*
Affiliation:
- Medical Research Center and Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan,China
Keywords:
LIM and SH3 domain protein 1, tumor microenvironment, oncogene, metastasis, nucleus translocation,
cytoskeleton.
Abstract: The growing evidence shows that LIM and SH3 Domain Protein 1 (LASP1) is
a multi-functional protein that plays important role in forming cytoskeleton and prognostic
marker in different cancers. LASP1 expression is correlated with the grade, size, and the
metastasis of tumor in clinical samples. And the upregulation of LASP1 facilitates tumor
cells proliferation, migration, and invasion perhaps through the interaction with
cytoskeleton and increased nuclear translocation. The underlying mechanism of LASP1
on tumor is still in the initial stage; therefore, the signaling pathways in various tumors
are specifically summarized to deepen the biological understanding of LASP1. This
article systematically summarizes the current status of knowledge regarding the
contribution of LASP1 in physiological and pathological processes, especially the
progress in tumor. This article also gives an emphasized overview of LASP1 on the
correlation with tumor microenvironment.
