Title:Aurora Kinase Inhibitors in Head and Neck Cancer
Volume: 18
Issue: 3
Author(s): Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang*Yasusei Kudo*
Affiliation:
- Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000,China
- Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8504,Japan
Keywords:
Aurora kinases, Mitosis, Head and neck cancer, Aurora kinase inhibitor, Tumor, Biological function.
Abstract: Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis.
In recent years, with the increase in Aurora kinase-related research, the important role of Aurora
kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new
target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application
of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent
a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent
years, including studies of their biological function, their relationship with tumor progression, and
their inhibitors.
